Herb & supplement monograph

Mangosteen Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Mangosteen interacts with medications. The heart of this page is the interaction list — every drug Mangosteen is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Mangosteen is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Interaction report

Drugs that interact with Mangosteen

125 medications have a known interaction with Mangosteen, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Mangosteen using our pharmacist-reviewed interaction data.

AI summaries are generated from our Mangosteen interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Mangosteen combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Mangosteen affects

Every type of medication (drug category) Mangosteen is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Mangosteen interacts with

Anticoagulant/antiplatelet DrugsDonepezil (aricept)

Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.

Likelihood Possible Evidence D

Donepezil (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.

Likelihood Possible Evidence D

Monograph

Mangosteen: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support, and general wellness, strong human evidence for these benefits is limited. It is likely fine as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Scientific name: Garcinia mangostana
Family: Clusiaceae
Part used: Fruit, and especially the rind (pericarp)
Common forms: Juice, capsules, tablets, powders, dried rind, extracts

People commonly use it for

Antioxidant support
Anti-inflammatory support
Immune support
Skin health
General wellness

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally considered safe as a food, but long-term safety of concentrated supplements is not well studied.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Mangosteen (Garcinia mangostana) is a tropical fruit native to Southeast Asia. It has a thick, deep purple rind and soft, sweet white segments inside. The fruit is enjoyed fresh in many parts of the world, but in supplements it is the rind, or pericarp, that gets the most attention.

The rind contains plant compounds called xanthones, which are antioxidants. Because of these compounds, mangosteen has been marketed in juices, capsules, and powders for a wide range of health claims. It has also been used in traditional medicine in some regions.

Today you will most often see mangosteen sold as a juice blend or as a supplement promising antioxidant, anti-inflammatory, or immune benefits.

How it works

The main active compounds in mangosteen are xanthones, especially one called alpha-mangostin. These are found mostly in the fruit's rind. In laboratory studies, xanthones act as antioxidants, meaning they may help neutralize unstable molecules called free radicals.

Lab and animal research also suggests xanthones may lower certain inflammation signals and have antimicrobial activity. Some studies hint at effects on blood sugar or cell growth.

It is important to remember that most of this work comes from cells in dishes or from animals. Whether these effects happen in the human body, at the amounts found in supplements, is not well established.

Effectiveness

Does Mangosteen work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 9 uses evaluated

1 Possibly effective 8 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

Possibly Effective Periodontitis