Medication interaction hub

What Supplements Interact with Guaifenesin, Theophylline?

Guaifenesin, Theophylline brand names: Mudrane GG-2, Bronchial, Theolair-Plus, Quibron, Quibron-300. Every interaction below applies to the brands too.

126 Interactions 3 Major 89 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guaifenesin, Theophylline? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guaifenesin, Theophylline against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

126 supplements and herbal ingredients have interactions with Guaifenesin, Theophylline on file in the HelloPharmacist interaction database — 3 rated major, 89 moderate, and 34 minor. The most serious involve Activated Charcoal, Ephedra and Sida Cordifolia.

Our assessment: with 3 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Guaifenesin, Theophylline.

Major 3 Moderate 89 Minor 34 No known interaction 1,326

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Guaifenesin, Theophylline: Top Interactions at a Glance

The Guaifenesin, Theophylline supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 126 interacting ingredients — plus 1,326 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Guaifenesin, Theophylline Combinations Today

The Guaifenesin, Theophylline + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Beet + Guaifenesin, Theophyllinei

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Probable Black Tea + Guaifenesin, Theophyllinei

Theoretically, black tea might increase the levels and adverse effects of theophylline.

Read the full interaction Moderate Likelihood Possible St. John's Wort + Guaifenesin, Theophyllinei

St.

Read the full interaction Moderate Likelihood Probable Ipriflavone + Guaifenesin, Theophyllinei

Concomitant use of theophylline and ipriflavone can increase serum theophylline levels.

Read the full interaction Major Likelihood Probable Activated Charcoal + Guaifenesin, Theophyllinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Guaifenesin, Theophyllinei

Concomitant use might increase the risk of serious adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Guaifenesin, Theophylline

All 1,452 ingredients in our database, ranked by severity — 126 with a Guaifenesin, Theophylline interaction on file and 1,326 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guaifenesin, Theophylline?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Beet with Guaifenesin, Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Full Beet + Guaifenesin, Theophylline answer

Can you take Black Tea with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea might increase the levels and adverse effects of theophylline.

Full Black Tea + Guaifenesin, Theophylline answer

Can you take St. John's Wort with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. St.

Full St. John's Wort + Guaifenesin, Theophylline answer

Can you take Ipriflavone with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of theophylline and ipriflavone can increase serum theophylline levels.

Full Ipriflavone + Guaifenesin, Theophylline answer

Can you take Resveratrol with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.

Full Resveratrol + Guaifenesin, Theophylline answer

Can you take Rooibos with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Guaifenesin, Theophylline answer

Can you take Schizonepeta with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Guaifenesin, Theophylline answer

Can you take Slippery Elm with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Guaifenesin, Theophylline answer

Can you take Sodium Bicarbonate with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking methylxanthines.

Full Sodium Bicarbonate + Guaifenesin, Theophylline answer

Can you take Sulforaphane with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.

Full Sulforaphane + Guaifenesin, Theophylline answer

Can you take Thuja with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Guaifenesin, Theophylline answer

Can you take Thunder God Vine with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.

Full Thunder God Vine + Guaifenesin, Theophylline answer

Can you take Tinospora Cordifolia with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.

Full Tinospora Cordifolia + Guaifenesin, Theophylline answer

Can you take Tragacanth with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Guaifenesin, Theophylline answer

Can you take Wheatgrass with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Full Wheatgrass + Guaifenesin, Theophylline answer

Can you take White Pepper with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white pepper might increase levels of theophylline.

Full White Pepper + Guaifenesin, Theophylline answer

Can you take Zizyphus with Guaifenesin, Theophylline?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Guaifenesin, Theophylline answer

Can you take Thyroid Extract with Guaifenesin, Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Guaifenesin, Theophylline answer

Can you take Adenosine with Guaifenesin, Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.

Full Adenosine + Guaifenesin, Theophylline answer

Can you take Agar with Guaifenesin, Theophylline?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Guaifenesin, Theophylline answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guaifenesin, Theophylline is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guaifenesin, Theophylline, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guaifenesin, Theophylline sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Guaifenesin, Theophylline through this category.

Theophylline 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Guaifenesin, Theophylline through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Guaifenesin, Theophylline through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Guaifenesin, Theophylline through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Guaifenesin, Theophylline through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Guaifenesin, Theophylline through this category.

Related: does Guaifenesin, Theophylline deplete any nutrients?

Guaifenesin, Theophylline has 5 reported nutrient associations in the research literature — see the Guaifenesin, Theophylline nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Guaifenesin, Theophylline

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guaifenesin, Theophylline.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Guaifenesin, Theophylline & Supplements: Common Questions

What supplements interact with Guaifenesin, Theophylline?
More than you might expect — 126 in total, though they are far from equal: 3 are rated major, 89 moderate, and 34 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Ephedra, Sida Cordifolia.
Which Guaifenesin, Theophylline supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra and Sida Cordifolia. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Guaifenesin, Theophylline?
Usually yes — most people on Guaifenesin, Theophylline can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Mudrane GG-2 have the same supplement interactions as Guaifenesin, Theophylline?
Yes — Mudrane GG-2, Bronchial, Theolair-Plus, Quibron, Quibron-300 all contain Guaifenesin, Theophylline, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Guaifenesin, Theophylline deplete any vitamins or nutrients?
It might — Guaifenesin, Theophylline has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Guaifenesin, Theophylline nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Guaifenesin, Theophylline and my other medications?
This page covers Guaifenesin, Theophylline against supplements and herbal ingredients. Checking Guaifenesin, Theophylline against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.