Medication interaction hub

What Supplements Interact with Mestranol, Norethynodrel?

Mestranol, Norethynodrel brand name: Enovid-E. Every interaction below applies to the brands too.

188 Interactions 6 Major 140 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Mestranol, Norethynodrel? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Mestranol, Norethynodrel against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The list for Mestranol and Norethynodrel (Enovid-E, a combined birth control pill) deserves genuine care, because several entries can quietly undo the pill itself. St. John's wort is the clearest example, speeding up how the hormones are broken down so blood levels drop, and activated charcoal can trap a dose in the gut before it ever absorbs. With a contraceptive, the failure mode is not a side effect but an unplanned pregnancy, which changes how seriously small interactions should be taken.

Other groups run the opposite way or add strain. Grapefruit can push hormone levels higher, heavy alcohol and certain herbs pile onto the liver work estrogens already do, and the pill slows caffeine clearance, so coffee and tea hit harder. Of 188 ingredients on file, 140 rate moderate and 42 minor, but the six rated major are where to start.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 140 Minor 42 No known interaction 1,264

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Mestranol, Norethynodrel: Top Interactions at a Glance

The Mestranol, Norethynodrel supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 188 interacting ingredients — plus 1,264 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Mestranol, Norethynodrel Combinations Today

The Mestranol, Norethynodrel + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Bitter Orange + Mestranol, Norethynodreli

Bitter orange might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Blond Psyllium + Mestranol, Norethynodreli

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Minor Likelihood Possible Hops + Mestranol, Norethynodreli

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Read the full interaction Minor Likelihood Possible Agar + Mestranol, Norethynodreli

Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Mestranol, Norethynodreli

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Boswellia Serrata + Mestranol, Norethynodreli

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Mestranol, Norethynodrel

All 1,452 ingredients in our database, ranked by severity — 188 with a Mestranol, Norethynodrel interaction on file and 1,264 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Mestranol, Norethynodrel?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bitter Orange with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Mestranol, Norethynodrel answer

Can you take Blond Psyllium with Mestranol, Norethynodrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Mestranol, Norethynodrel answer

Can you take Hops with Mestranol, Norethynodrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.

Full Hops + Mestranol, Norethynodrel answer

Can you take Agar with Mestranol, Norethynodrel?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Mestranol, Norethynodrel answer

Can you take Eucalyptus with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Mestranol, Norethynodrel answer

Can you take Fo-ti with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking large amounts of fo-ti might interfere with contraceptive drugs due to competition for estrogen receptors.

Full Fo-ti + Mestranol, Norethynodrel answer

Can you take Glucomannan with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Mestranol, Norethynodrel answer

Can you take Green Coffee with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in green coffee.

Full Green Coffee + Mestranol, Norethynodrel answer

Can you take Green Tea with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in green tea.

Full Green Tea + Mestranol, Norethynodrel answer

Can you take Guggul with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Mestranol, Norethynodrel answer

Can you take Ilex Guayusa with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in Ilex guayusa.

Full Ilex Guayusa + Mestranol, Norethynodrel answer

Can you take Melatonin with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.

Full Melatonin + Mestranol, Norethynodrel answer

Can you take Schisandra with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Mestranol, Norethynodrel answer

Can you take Tree Turmeric with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Mestranol, Norethynodrel answer

Can you take Acacia Rigidula with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP3A4 su...

Full Acacia Rigidula + Mestranol, Norethynodrel answer

Can you take Adrafinil with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafanil might reduce levels and clinical effects of CYP3A4 substrates.

Full Adrafinil + Mestranol, Norethynodrel answer

Can you take African Wild Potato with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract can inhibit cytochrome P450 3A4 (CYP3A4) enzyme activity by up to 86%.

Full African Wild Potato + Mestranol, Norethynodrel answer

Can you take Alfalfa with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alfalfa might interfere with the activity of contraceptive drugs.

Full Alfalfa + Mestranol, Norethynodrel answer

Can you take American Elder with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking American elder might increase levels of CYP3A4 substrates.

Full American Elder + Mestranol, Norethynodrel answer

Can you take Anise with Mestranol, Norethynodrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise might interfere with contraceptive drug therapy.

Full Anise + Mestranol, Norethynodrel answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Mestranol, Norethynodrel is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Mestranol, Norethynodrel, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Mestranol, Norethynodrel sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Mestranol, Norethynodrel through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Mestranol, Norethynodrel through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Mestranol, Norethynodrel through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Mestranol, Norethynodrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Mestranol, Norethynodrel through this category.

Related: does Mestranol, Norethynodrel deplete any nutrients?

Mestranol, Norethynodrel has 2 reported nutrient associations in the research literature — see the Mestranol, Norethynodrel nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Mestranol, Norethynodrel

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Mestranol, Norethynodrel.

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Pharmacist Counseling Corner

Mestranol, Norethynodrel & Supplements: Common Questions

What supplements interact with Mestranol, Norethynodrel?
More than you might expect — 188 in total, though they are far from equal: 6 are rated major, 140 moderate, and 42 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Mestranol, Norethynodrel supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Mestranol, Norethynodrel?
Usually yes — most people on Mestranol, Norethynodrel can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Enovid-E have the same supplement interactions as Mestranol, Norethynodrel?
Yes — Enovid-E all contain Mestranol, Norethynodrel, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Mestranol, Norethynodrel deplete any vitamins or nutrients?
It might — Mestranol, Norethynodrel has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Mestranol, Norethynodrel nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Mestranol, Norethynodrel and my other medications?
This page covers Mestranol, Norethynodrel against supplements and herbal ingredients. Checking Mestranol, Norethynodrel against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.