Medication interaction hub

What Supplements Interact with Montelukast Sodium?

Montelukast Sodium brand name: Singulair. Every interaction below applies to the brands too.

81 Interactions 1 Major 56 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 17, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Montelukast Sodium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Montelukast Sodium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you rely on montelukast (Singulair) for asthma or allergies, this list deserves genuine attention. The one major-rated concern is activated charcoal, which can soak up the medicine in your gut before it absorbs, leaving you with a weaker dose just when your airways need a steady one. Nearly everything else pushes the opposite way. Dozens of herbs and supplements, CBD among them, can interfere with the liver enzyme (CYP2C9) that helps clear montelukast, usually slowing it, which may let the drug's levels creep higher than intended.

A smaller cluster affects how oral medicines absorb in general, bulking fibers like glucomannan for instance, so space those well apart from your dose. Much of the evidence is early, lab and animal work more than human trials, though the pattern repeats often enough to respect. Of the 81 ingredients on file, one rates major, 56 moderate, and 24 minor, and the charcoal question is the one worth settling before the rest.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 56 Minor 24 No known interaction 1,371

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Montelukast Sodium: Top Interactions at a Glance

The most significant Montelukast Sodium supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 81 interacting ingredients — plus 1,371 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Montelukast Sodium + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Montelukast Sodiumi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Montelukast Sodium

All 1,452 ingredients in our database, ranked by severity — 81 with a Montelukast Sodium interaction on file and 1,371 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Montelukast Sodium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Rabdosia Rubescens with Montelukast Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 2C9 (CYP2C9) enzyme.

Full Rabdosia Rubescens + Montelukast Sodium answer

Can you take Phellodendron with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.

Full Phellodendron + Montelukast Sodium answer

Can you take Propolis with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.

Full Propolis + Montelukast Sodium answer

Can you take Puravive with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains quercetin, which has been shown in studies to mildly inhibit the CYP2C9 metabolizing enzyme.

Full Puravive + Montelukast Sodium answer

Can you take Quercetin with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2C9 substrates.

Full Quercetin + Montelukast Sodium answer

Can you take Rhodiola with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.

Full Rhodiola + Montelukast Sodium answer

Can you take Rooibos with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2C9 substrates may increase the effects of CYP2C9 substrates.

Full Rooibos + Montelukast Sodium answer

Can you take Sage with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.

Full Sage + Montelukast Sodium answer

Can you take Schisandra with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.

Full Schisandra + Montelukast Sodium answer

Can you take Sesame with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sesame might increase the levels and clinical effects of CYP2C9 substrates.

Full Sesame + Montelukast Sodium answer

Can you take Slippery Elm with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Montelukast Sodium answer

Can you take St. John's Wort with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. St.

Full St. John's Wort + Montelukast Sodium answer

Can you take Terminalia with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2C9 substrates.

Full Terminalia + Montelukast Sodium answer

Can you take Tinospora Cordifolia with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2C9.

Full Tinospora Cordifolia + Montelukast Sodium answer

Can you take Tragacanth with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Montelukast Sodium answer

Can you take Tree Turmeric with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2C9.

Full Tree Turmeric + Montelukast Sodium answer

Can you take Vinpocetine with Montelukast Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vinpocetine might increase levels of drugs metabolized by CYP2C9.

Full Vinpocetine + Montelukast Sodium answer

Can you take Thyroid Extract with Montelukast Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Montelukast Sodium answer

Can you take Agar with Montelukast Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Montelukast Sodium answer

Can you take Algin with Montelukast Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Montelukast Sodium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Montelukast Sodium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Montelukast Sodium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Montelukast Sodium sits in 2 interaction categories. Open any one to see what the group means:

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Montelukast Sodium through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Montelukast Sodium through this category.

About Montelukast Sodium

Montelukast is a leukotriene receptor antagonist used to prevent asthma symptoms and treat allergic rhinitis.

Generic name: Montelukast Sodium  ·  Brand name: Singulair.

See the full Montelukast drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Montelukast Sodium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Montelukast Sodium.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Montelukast Sodium & Supplements: Common Questions

What supplements interact with Montelukast Sodium?
More than you might expect — 81 in total, though they are far from equal: 1 are rated major, 56 moderate, and 24 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Cannabidiol (cbd), Coffee Charcoal.
Which Montelukast Sodium supplement interactions are the most serious?
Focus on the major group: Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Montelukast Sodium?
Usually yes — most people on Montelukast Sodium can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Singulair have the same supplement interactions as Montelukast Sodium?
Yes — Singulair all contain Montelukast Sodium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Montelukast Sodium and my other medications?
This page covers Montelukast Sodium against supplements and herbal ingredients. Checking Montelukast Sodium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Montelukast drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 17, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.