Medication interaction hub

What Supplements Interact with Zafirlukast?

Zafirlukast brand name: Accolate. Every interaction below applies to the brands too.

88 Interactions 1 Major 64 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Zafirlukast? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Zafirlukast against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

88 supplements and herbal ingredients have interactions with Zafirlukast on file in the HelloPharmacist interaction database — 1 rated major, 64 moderate, and 23 minor. The most serious involve Activated Charcoal.

Our assessment: with 1 major-rated interaction on the list, this one deserves real attention — know the major entries before combining anything with Zafirlukast.

Major 1 Moderate 64 Minor 23 No known interaction 1,364

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Zafirlukast: Top Interactions at a Glance

The most significant Zafirlukast supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 88 interacting ingredients — plus 1,364 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Zafirlukast + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Zafirlukasti

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Zafirlukast

All 1,452 ingredients in our database, ranked by severity — 88 with a Zafirlukast interaction on file and 1,364 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Zafirlukast?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Devil's Claw with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.

Full Devil's Claw + Zafirlukast answer

Can you take Diosmin with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP2C9 substrates.

Full Diosmin + Zafirlukast answer

Can you take Eleuthero with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.

Full Eleuthero + Zafirlukast answer

Can you take Ergot with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ergotamine, a constituent of ergot, is a substrate of cytochrome P450 3A4 (CYP3A4).

Full Ergot + Zafirlukast answer

Can you take Eucalyptus with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.

Full Eucalyptus + Zafirlukast answer

Can you take Evodia with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of evodia.

Full Evodia + Zafirlukast answer

Can you take Fever Bark with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of yohimbine, a constituent of fever bark.

Full Fever Bark + Zafirlukast answer

Can you take Feverfew with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.

Full Feverfew + Zafirlukast answer

Can you take Fo-ti with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C9.

Full Fo-ti + Zafirlukast answer

Can you take German Chamomile with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Zafirlukast answer

Can you take Ginkgo with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might increase levels of drugs metabolized by CYP2C9.

Full Ginkgo + Zafirlukast answer

Can you take Goji with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP2C9 and reduce metabolism of CYP2C9 substrates.

Full Goji + Zafirlukast answer

Can you take Goldenseal with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase serum levels of drugs metabolized by CYP2C9.

Full Goldenseal + Zafirlukast answer

Can you take Grapefruit with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP2C9.

Full Grapefruit + Zafirlukast answer

Can you take Guar Gum with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Zafirlukast answer

Can you take Gum Arabic with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Zafirlukast answer

Can you take Gymnema with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.

Full Gymnema + Zafirlukast answer

Can you take Ipriflavone with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9).

Full Ipriflavone + Zafirlukast answer

Can you take Jambolan with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some in vitro evidence that jambolan can inhibit CYP2C9.

Full Jambolan + Zafirlukast answer

Can you take Kava with Zafirlukast?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kava might increase levels of CYP2C9 substrates.

Full Kava + Zafirlukast answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Zafirlukast is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Zafirlukast, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Zafirlukast sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Zafirlukast through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Zafirlukast through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Zafirlukast through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Zafirlukast through this category.

About Zafirlukast

Zafirlukast is a prescription oral tablet used for the long-term prevention and management of asthma in adults and children aged 5 and older.

Generic name: Zafirlukast  ·  Brand name: Accolate.

See the full Zafirlukast drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Zafirlukast

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Zafirlukast.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Zafirlukast & Supplements: Common Questions

What supplements interact with Zafirlukast?
Our database currently documents 88 ingredients with a known Zafirlukast interaction (1 major, 64 moderate, 23 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 88. The highest-ranked right now: Activated Charcoal, Cannabidiol (cbd), Coffee Charcoal.
Which Zafirlukast supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Zafirlukast?
Plenty of supplements coexist fine with Zafirlukast; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Accolate have the same supplement interactions as Zafirlukast?
Yes — Accolate all contain Zafirlukast, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Zafirlukast and my other medications?
This page covers Zafirlukast against supplements and herbal ingredients. Checking Zafirlukast against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Zafirlukast drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.