Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

CardioRegain Ingredients & Drug Interactions

by LABO Nutrition

CardioRegain label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CardioRegain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CardioRegain is a dietary supplement by LABO Nutrition with 4 active ingredients. Its ingredients are commonly taken for antioxidant support, skin health and aging, eye health.Based on those ingredients, 1,086 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are AstaReal, Pine Bark Extract, Superba2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CardioRegain by LABO Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with CardioRegain by LABO Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of CardioRegain by LABO Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

CardioRegain contains four active ingredients. Three of them are well established: astaxanthin (AstaReal), a red carotenoid antioxidant from algae; coenzyme Q10 (Kaneka QH), a naturally occurring compound involved in energy production in your cells; and krill oil (Superba2), a marine-derived source of omega-3 fatty acids.

The fourth ingredient is Pine Bark Extract, which we hold no interaction data for. The product is filled with olive oil and glycerol esters.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Heart health and blood pressure support.
  • We looked for evidence on: Cardiovascular disease (CVD), Congestive heart failure (CHF), Heart failure, Hypertension, Hyperlipidemia, Hypertriglyceridemia — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Likely Effective" for Coenzyme Q10 deficiency (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF), Myocardial infarction (MI).
  • Also on file: Maritime Pine is rated "Possibly Ineffective" for Hyperlipidemia.

The evidence for these ingredients varies widely. Coenzyme Q10 is rated Likely Effective for CoQ10 deficiency itself, and Possibly Effective for fibromyalgia, migraines, congestive heart failure, and diabetic nerve pain.

Krill oil is rated Possibly Effective for dry eye. Astaxanthin and the other proposed uses lack sufficient reliable evidence to rate them.

We hold no effectiveness data for Pine Bark Extract.

The evidence, ingredient by ingredient Astaxanthin Coenzyme Q10 Krill Oil Maritime Pine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coenzyme Q10 is generally well tolerated; minor gastrointestinal side effects like nausea, diarrhea, or heartburn occur in less than 1% of people. Krill oil is also generally well tolerated up to 4 grams daily, though some people experience bloating, stomach discomfort, or fishy burps.

Astaxanthin is generally well tolerated, though higher doses have caused stomach pain and increased bowel movements in a small number of trial participants. Astaxanthin should be avoided during pregnancy and while breastfeeding due to insufficient safety data.

Krill oil and coenzyme Q10 also lack enough safety data in pregnancy and breastfeeding—talk with your doctor before using them if you are pregnant or nursing. Krill oil should be avoided if you have a shellfish allergy.

Side effects, ingredient by ingredient Astaxanthin Coenzyme Q10 Krill Oil Maritime Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Coenzyme Q10, Maritime Pine, Astaxanthin, Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,087 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CardioRegain, double-check whether you take blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel—krill oil and coenzyme Q10 may affect their action. Blood pressure medications, diabetes drugs, chemotherapy (especially alkylating agents), and drugs metabolized through your liver's CYP3A4 or CYP2B6 pathways should also be reviewed with your pharmacist, as astaxanthin and coenzyme Q10 may alter their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

CardioRegain may be worth considering if you're interested in heart and eye health support and you don't take blood thinners, diabetes medications, or certain cancer drugs. If you take any prescription medication—especially warfarin, antihypertensive drugs, diabetes medications, or chemotherapy—check your specific drugs with the tool on this page before starting.

Talk with your pharmacist about whether this product fits your health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CardioRegain, straight from the product label.

Brand LABO Nutrition
Barcode (UPC) 8885003050137
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 295369
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CardioRegain by LABO Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
8885003050137
IngredientAmount% DV
AstaReal4 mg--
Kaneka QH100 mg--
Superba2100 mg--
Pine Bark Extract20 mg--

Other ingredients: Olive Oil, Glycerol Esters

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

No.1 most researched heart nutrients

Gold standard

Formula

Ubiquinol CoQ10 Astaxanthin Pine bark extract Krill oil

Active ubiquinol and antioxidants

CardioREGAIN is a synergistic & functional heart formula made with the world's most recognised and researched micronutrients, to nourish the heart and protect blood vessels. Active ubiquinol (a bioavailable form of coenzyme Q10) provides cellular energy to the heart muscles and major organs Active antioxidants: Astaxanthin and pine bark extract improve heart health and help reduce oxidative stress and plaque formation in the blood vessels

Formulation

Ultra strength Active form Smart delivery Absorption up to 25 times Helps replenish plasma CoQ10 levels Supports heart health & blood pressure Supports cellular energy production Protects mitochondria from free radicals

Smart liposomal delivery Superior bioavailability Stable, safe, research proven

Gluten-free. No wheat, milk derivatives, preservatives, artificial colouring or flavoring. Safe and free of heavy metals.

Made in Japan

CardioRegain - Comprehensive heart health formula An unhealthy lifestyle, oxidative stress and the use of cholesterol-lowering statins deteriorate one's cardiovascular health. As the body's natural heart nutrients like Coenzyme Q10 and antioxidants reduce with age, the "malnourished" heart has to work harder to pump blood through stiff and clogged blood vessels. Over time, serious cardiovascular problems can arise. A 2-prong approach to (1) strengthen the heart and (2) reduce cholesterol oxidation and plaque build-up in the blood vessels, clears the path for good circulation while protecting the heat from overworking. Smart liposomal delivery improves absorption by up to 25 times

Supports healthy blood pressure, heart rate, blood circulation, energy and well-being Smart liposmal delivery Increases absorption of ubiquinol and protects it from destruction by enzymes, stomach acid and oxidation.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

One-a-day

Recommended dosage: Take 1 softgel daily after meals.

Precautions

Allergens: contains crustaceans

Caution: Do not take without medical advice if on warfarin. If you are pregnant, nursing or taking medications, please consult your physician before consuming any supplements.

Please exercise caution if you are allergic to shellfish.

Dietary supplements are not a substitute for a healthy diet.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place, away from direct sunlight and moisture.

Seals/Symbols

Good Manufacturing Practice GMP Certified Made with Quality Q+ Kaneka Ubiquinol

Brand IP Statement(s)

AstaReal Astaxanthin AstaReal is a trademark of Fuji Chemical Industries Co., Ltd. Kaneka Ubiquinol is a trademark of Kaneka Corporation. Superba 2 is a trademark of the Aker Group.

Labo + nutrition The best or nothing

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CardioRegain by LABO Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CardioRegain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CardioRegain by LABO Nutrition

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

AstaReal

Interacts with
671 drugs
4 mg per serving Form: Astaxanthin

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

AstaReal monograph & interactions

Kaneka QH

Interacts with
198 drugs
100 mg per serving Form: Ubiquinol

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Kaneka QH monograph & interactions

Superba2

Interacts with
208 drugs
100 mg per serving Form: Krill Oil

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Superba2 monograph & interactions

Pine Bark Extract

Interacts with
327 drugs
20 mg per serving Form: Pinus radiata

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

Pine Bark Extract monograph & interactions

Other (inactive) ingredients: Olive Oil, Glycerol Esters. These complete the product’s ingredient list but are not active constituents.

Interaction report

CardioRegain by LABO Nutrition Drug Interactions

Want to check YOUR meds against CardioRegain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,086Drugs
948 Moderate 138 Minor

Ingredients driving the most interactions

AstaReal 671
Pine Bark Extract 327
Superba2 208
Kaneka QH 198

Individual Drug Interactions

The ingredients in CardioRegain interact with 1,086 drugs. Click any drug to see the details.

4 of the 4 ingredients in CardioRegain interact with drugs. Each result below shows which ingredient is responsible. AstaReal Pine Bark Extract Superba2 Kaneka QH

Each ingredient & the kinds of drugs it affects

For each ingredient in CardioRegain with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

AstaReal2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
AstaReal full monograph & interactions

Pine Bark Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Pine Bark Extract full monograph & interactions

Superba22 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Superba2 full monograph & interactions

Kaneka QH3 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Kaneka QH full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CardioRegain, from the product label.

LABO Nutrition

See all LABO Nutrition products
Name
Lifestream Group Pte Ltd
Street Address
159 Kampong Ampat #05-01
ZipCode
368328
Phone Number
(65) 6535-7333
Pharmacist Counseling Corner

CardioRegain by LABO Nutrition: Common Questions

Does CardioRegain by LABO Nutrition interact with any medications?
Yes. Based on its ingredients, CardioRegain has a known interaction with 1,086 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CardioRegain contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does astaxanthin actually lower blood pressure or improve skin?
The evidence isn't established in our data. We don't have enough reliable evidence to rate astaxanthin for those uses.
What if I'm pregnant or breastfeeding?
Astaxanthin should be avoided during pregnancy and breastfeeding—there isn't enough safety data. For coenzyme Q10 and krill oil, safety data is also limited; talk with your doctor before using them if you're pregnant or nursing to make sure it's right for you.
Can this give me stomach upset?
Yes, it's possible. Krill oil commonly causes bloating, stomach discomfort, or fishy burps. Coenzyme Q10 can cause nausea, diarrhea, or heartburn in less than 1% of people. Astaxanthin may cause diarrhea or stomach pain, especially at higher doses.
Why is there an ingredient you can't check?
Pine Bark Extract doesn't have an interaction monograph on file with us, so we simply have no data to check it against. That doesn't mean it's safe or unsafe—we just can't verify it either way.
Is coenzyme Q10 good for heart health?
Coenzyme Q10 is rated Possibly Effective for congestive heart failure. For general heart health without heart failure, the evidence isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CardioRegain label
Go deeper

The Full Monographs Behind CardioRegain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph → Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph →
Sources

Sources & How We Checked

CardioRegain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Coenzyme Q10 40 references
  1. Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-51. PubMed
  2. Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72. PubMed
  3. Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. PubMed
  4. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8. PubMed
  5. Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. PubMed
  6. Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. PubMed
  7. Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. PubMed
  8. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  9. Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7.
  10. Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. PubMed
  11. Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. PubMed
  12. The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404.
  13. Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42. PubMed
  14. Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82. DOI
  15. Porterfield LM. Why did the response to warfarin change? RN 2000;63:107.
  16. Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5. PubMed
  17. Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. DOI
  18. Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9. PubMed
  19. Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol 2007;64:938-44. DOI
  20. Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63. PubMed
  21. Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. In: Folkers KA, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 5. Amsterdam: Elsevier Science Publications, 19
  22. Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Cochrane Database Syst Rev 2009;(4):CD007435. PubMed
  23. Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., and Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum.Hypertens. 2007;21(4):297-306. PubMed
  24. Stamelou, M., Reuss, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade-Brittinger, C., Oertel, W. H., and Hoglinger, G. U. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, place DOI
  25. Keogh A, Fenton S, Leslie C, et al. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12:135-41.
  26. Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A., and Murphy, M. P. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C
  27. Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-947. PubMed
  28. Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., and George, P. M. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the me
  29. Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn.Heart J 1976;17(1):32-42. PubMed
  30. Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43(5
  31. Malm, C., Svensson, M., Sjoberg, B., Ekblom, B., and Sjodin, B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand. 1996;157(4):511-512. PubMed
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Krill Oil 13 references
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Maritime Pine 14 references
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See these in context on the Maritime Pine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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