Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

E-W Ingredients & Drug Interactions

by Pure Herbs

E-W label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking E-W against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

E-W is a dietary supplement by Pure Herbs with 3 active ingredients. Its ingredients are commonly taken for diarrhea and digestive upset, sore throat and cold symptoms, gum and mouth rinse (gargle).Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eyebright Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against E-W by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with E-W by Pure Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of E-W by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,937 mg) without saying how much of each component you get.

This liquid contains three active ingredients: bayberry root bark extract, wood betony aerial parts extract, and eyebright aerial parts extract. There are no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports healthy circulatory system and eye health.
  • We looked for evidence on: Asthenopia (eye strain), Conjunctivitis, Blepharitis, eye irritation, eye redness, circulation.
  • The closest evidence on file: Eyebright is rated "Insufficient Reliable Evidence To Rate" for Blepharitis (Natural Medicines).
  • Also on file: Eyebright is rated "Insufficient Reliable Evidence To Rate" for Asthenopia (eye strain), Conjunctivitis.

The evidence for this product's ingredients isn't established. Eyebright has been studied for allergic rhinitis (hay fever), common cold, cough, pharyngitis, and sinus inflammation, but the data we hold rates all of these as having insufficient reliable evidence.

Bayberry and wood betony effectiveness ratings aren't on file.

The evidence, ingredient by ingredient Bayberry Eyebright

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bayberry root bark can cause stomach irritation, vomiting, and in larger amounts, potentially liver damage — likely because of its tannin content. It can also act as an irritant and sensitizer on the skin.

Eyebright taken by mouth has been reported to cause confusion, headache, nausea, constipation, cough, shortness of breath, and nasal congestion in some people. The safety data advises against bayberry during pregnancy and while breastfeeding because there isn't enough information to know it's safe.

Eyebright hasn't been established as safe in pregnancy or breastfeeding either — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Bayberry Eyebright

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eyebright.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (medications for diabetes), double-check with your doctor or pharmacist before adding this product — eyebright may increase the risk of low blood sugar. For the other ingredients we could check, no interactions are documented in our data, though we hold no interaction data for wood betony.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take diabetes medication, check with your doctor or pharmacist before starting — eyebright may raise the risk of low blood sugar. This product is best avoided during pregnancy and breastfeeding due to limited safety data.

Because bayberry can irritate the stomach in larger amounts, start cautiously and stop if you notice nausea or stomach upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about E-W, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279923
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for E-W by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Proprietary Blend1937 mg--
Bayberry Root Bark Extract0 NP--
Wood Betony Aerial Parts Extract0 NP--
Eyebright Aerial Parts Extract0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Supports a healthy circulatory system. Beneficial in the maintenance of eye health.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

E-W by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

E-W label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in E-W by Pure Herbs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1937 mg per serving

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

E-W by Pure Herbs Drug Interactions

Want to check YOUR meds against E-W?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Eyebright Aerial Parts Extract 86

Individual Drug Interactions

The ingredients in E-W interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in E-W interact with drugs. Each result below shows which ingredient is responsible. Eyebright Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in E-W with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Eyebright Aerial Parts Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, eyebright might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that eyebright lowers blood glucose levels.

Likelihood Possible Evidence D
Eyebright Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for E-W, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

E-W by Pure Herbs: Common Questions

Does E-W by Pure Herbs interact with any medications?
Yes. Based on its ingredients, E-W has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
E-W contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it. Bayberry is rated possibly unsafe during pregnancy and breastfeeding, and eyebright hasn't been established as safe in either. Talk with your doctor or pharmacist about your specific situation — they can give you personalized guidance.
What side effects might I notice?
Bayberry can cause stomach irritation, vomiting, and possibly liver damage, especially in larger amounts. Eyebright has been reported to cause confusion, headache, nausea, constipation, cough, shortness of breath, and nasal congestion. If any of these bother you, stop and talk with your pharmacist.
Does this product actually work for colds or hay fever?
Eyebright is the ingredient studied for those uses, but the evidence we hold rates it as insufficient — meaning there isn't enough reliable data to say whether it works. The other ingredients' effectiveness isn't on file.
Is it safe to use eyebright directly in my eyes?
No — the safety data cautions against homemade or non-sterile preparations in the eye because of the risk of infection or damage. This product is taken by mouth, which is the safer route.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

E-W label
Go deeper

The Full Monographs Behind E-W’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bayberry

Bayberry is a traditional herb used mainly as an astringent for diarrhea, sore throats, and minor skin or gum problems, but there is very little modern human research to confirm it works. It...

Read the full Bayberry monograph → Herb & supplement monograph

Eyebright

Interacts with 86 drugs

Eyebright is a traditional herb long used for minor eye irritation, redness, and allergy symptoms, but high-quality human studies are very limited. There is not enough reliable evidence to c...

Read the full Eyebright monograph →
Sources

Sources & How We Checked

E-W's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bayberry 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

See these in context on the Bayberry monograph →

Eyebright 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  4. Porchezhian, E., Ansari, S. H., and Shreedharan, N. K. Antihyperglycemic activity of Euphrasia officinale leaves. Fitoterapia 2000;71(5):522-526. PubMed

See these in context on the Eyebright monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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