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Vitamin D is a fat-soluble vitamin that plays a crucial role in several bodily processes. It helps the body absorb calcium and phosphorus, which are necessary for healthy bones and teeth. It is also important for immune system function and may help to protect against certain diseases. Vitamin D is found in a variety of foods, including fatty fish, egg yolks, and fortified foods such as milk and cereal. It is also produced by the body when the skin is exposed to sunlight. Vitamin D supplements are available in a variety of forms, including tablets, capsules, and liquids. The recommended daily intake of vitamin D varies depending on age, sex, and other factors, and it is important to follow the dosage recommendations provided by a healthcare professional. There are several different forms of vitamin D available, with the two most popular being ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3).

Vitamin B12, also known as cobalamin, is a water-soluble vitamin crucial for several bodily functions. It plays a pivotal role in the formation of red blood cells, aiding in the prevention of anemia. Vitamin B12 is essential for maintaining a healthy nervous system and proper brain function, as it is involved in the synthesis of myelin, the protective sheath around nerve fibers. This vitamin is primarily found in animal-based foods such as meat, fish, dairy products, and eggs, making it important for vegetarians and vegans to consider supplementation. A deficiency in vitamin B12 can lead to neurological issues, fatigue, and cognitive impairment.

Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Grapes are widely grown and cultivated for a variety of uses such as for food and beverage making (e.g., wine). They also have a long history of use in traditional medicine. The fruit and skin of grapes contain various compounds that are believed to have health benefits, including antioxidants such as resveratrol and flavonoids. These compounds may help to protect cells from damage and are purported to reduce the risk of certain chronic diseases. Grapes and grape products may also have anti-inflammatory properties, which may help to reduce inflammation in the body and potentially improve symptoms of certain conditions. Grape seed extracts are also commonly used as a dietary supplement and are often standardized according to the content of polyphenols or proanthocyanidins.