HeartLight Ingredients & Drug Interactions
What is this page for?
First and foremost: checking HeartLight against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
HeartLight is a dietary supplement by Harmonic Innerprizes with 5 active ingredients. Its ingredients are commonly taken for exercise performance and recovery, heart health, weight management.Based on those ingredients, 1,179 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are BioPerine, CoQ10, Hawthorne flowers & berries extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against HeartLight by Harmonic Innerprizes
Ask about any prescription or over-the-counter medication and we check it for interactions with HeartLight by Harmonic Innerprizes — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of HeartLight by Harmonic Innerprizes
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
HeartLight contains five active ingredients. BioPerine is black pepper extract, included to enhance absorption.
L-carnitine tartrate is an amino acid compound; the product lists carnitine deficiency as effectively addressed by this form, and possibly effective for high cholesterol, heart failure, and chest pain. CoQ10 (coenzyme Q10) is a compound your body makes; it's listed as likely effective for CoQ10 deficiency and possibly effective for heart failure, migraines, and diabetic nerve pain.
Hawthorn flowers and berries extract is an herbal preparation — though the data shows insufficient evidence for most of its claimed cardiovascular uses, it appears in this heart-focused formula. Etherium Pink is the fifth ingredient, but we have no data on file for it.
The product also contains inactive ingredients — hydroxypropylmethylcellulose, beta-cyclodextrin, a silicon mineral complex, calcium stearate, silicon dioxide, and water — which serve as capsule material and fillers.
Does it work?
Strong evidence
The evidence for most of what's in HeartLight is mixed or limited. L-carnitine is effective for carnitine deficiency and possibly effective for high cholesterol, heart failure, and chest pain.
CoQ10 is likely effective for CoQ10 deficiency and possibly effective for heart failure, migraines, and diabetic nerve pain. BioPerine (black pepper) has insufficient evidence for hay fever, asthma, athletic performance, headache, depression, or diarrhea — so we don't know if it actually helps with those conditions.
Hawthorn similarly shows insufficient evidence for its claimed benefits: angina, anxiety, heart rhythm problems, hardening of arteries, heart disease, or brain function. The evidence is just not established in our data for most of what hawthorn is supposed to do, even though it's in a heart-support formula.
How safe is it?
Well-documented data
Overall, the ingredients in HeartLight are generally well tolerated at typical doses, though each has caveats. BioPerine (black pepper) is safe as a food spice; concentrated supplements should be used more cautiously, and side effects from food amounts are rare — mostly burning aftertaste, upset stomach, and occasionally cough if inhaled.
A severe allergic reaction is very rare. L-carnitine commonly causes stomach upset (nausea, diarrhea, cramping, heartburn) and can produce a fish-like body odor at higher doses; seizures are rare.
CoQ10 causes gastrointestinal side effects (nausea, diarrhea, heartburn) in less than 1% of users; headache, dizziness, and insomnia have been reported, and skin rashes are uncommon. Hawthorn is generally well tolerated in studies but requires medical supervision if you have a heart condition; rare serious allergic reactions affecting multiple organs have occurred.
For pregnancy, BioPerine is listed as both likely safe and likely unsafe in the data — talk with your doctor for personalized advice. L-carnitine pregnancy safety is not rated in our data; lactation is possibly safe.
CoQ10 lactation safety is not rated. Hawthorn is not recommended during pregnancy or breastfeeding due to insufficient safety information.
Meds to double-check
Major interaction found
Before taking HeartLight, double-check these medication types with your doctor or pharmacist: nitrates and erectile dysfunction drugs like sildenafil (Viagra) — hawthorn may cause dangerous blood pressure drops; blood thinners like warfarin and antiplatelet drugs — both L-carnitine and hawthorn may increase bleeding risk or reduce effectiveness; heart drugs including beta-blockers, calcium channel blockers, and digoxin — hawthorn may amplify their effects; blood pressure medications — CoQ10 may lower pressure further; seizure medicines like phenytoin — black pepper may raise levels dangerously; antibiotics like rifampin — black pepper may raise levels; the antiviral nevirapine — black pepper may raise levels; antidepressants and sedatives like pentobarbital — black pepper may increase effects; cholesterol drugs like atorvastatin — black pepper may raise levels; asthma medications like theophylline — black pepper may raise levels; thyroid hormone replacement — L-carnitine may reduce effectiveness; and immune suppressants like cyclosporine — black pepper may raise levels. Altogether, these interactions span 1,180 individual medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
HeartLight brings together supplements with some evidence for heart and circulation support — chiefly L-carnitine and CoQ10 — but the hawthorn and black pepper components lack strong evidence for the claims made here. The real concern is that hawthorn interacts dangerously with blood pressure and heart medications, and black pepper can raise blood levels of many drugs.
If you take any prescription medication, especially heart drugs, blood thinners, seizure medicines, antibiotics, or thyroid hormone, you need to check with your doctor or pharmacist before starting this product. Even if you don't take medications now, talk it over with your healthcare provider first — some of these ingredients can change how your heart and blood vessels respond to treatment.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about HeartLight, straight from the product label.
| Brand | Harmonic Innerprizes |
|---|---|
| Barcode (UPC) | 640627451207 |
| Net contents | 120 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 22, 2017 |
| DSLD ID | 81612 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for HeartLight by Harmonic Innerprizes, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| BioPerine | 0 NP | -- |
| L-Carnitine Tartrate | 500 mg | -- |
| Proprietary Blend | 340 mg | -- |
| CoQ10 | 120 mg | -- |
| Hawthorne flowers & berries extract | 0 NP | -- |
| Etherium Pink | 0 NP | -- |
Other ingredients: Hydroxypropylmethylcellulose, Beta-Cyclodextrin, Silicon Mineral Complex, Calcium Stearate, Silicon Dioxide, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
As we age, our body loses its ability to produce CoQ10; a powerful antioxidant and along with Carnitine which forms ATP, necessary for the body's energy production. HeartLight provides patented MicroActive CoQ10 for its superior absorption and is time released over 24 hours.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition or are taking any medication.
Keep out of reach of children.
Formulation
Hypoallergenic: This product does not contain soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, yeast, salt, preservatives, artificial color, flavor, or fragrances.
GMO free
Brand IP Statement(s)
BioPerine is a trademark of Sabinsa
MicroActive CoQ10 is a registered trademark of BioActive, LLC
2015 HarmonicInnerprizes, Inc.
General Statements
300% better absorption of CoQ10
Cardio Care Series
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 2 capsules with a meal, preferably breakfast.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
HeartLight by Harmonic Innerprizes label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in HeartLight by Harmonic Innerprizes
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Vegetable Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Carnitine Tartrate
Interacts with19 drugs
L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...
L-Carnitine Tartrate monograph & interactionsProprietary Blend
- › BioPerine
- › Hawthorne flowers & berries extract
- › Etherium Pink
CoQ10
Interacts with198 drugs
CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...
CoQ10 monograph & interactionsOther (inactive) ingredients: Hydroxypropylmethylcellulose, Beta-Cyclodextrin, Silicon Mineral Complex, Calcium Stearate, Silicon Dioxide, Water. These complete the product’s ingredient list but are not active constituents.
HeartLight by Harmonic Innerprizes Drug Interactions
HelloPharmacist Interaction Report
HeartLight by Harmonic Innerprizes interacts with medications through its BioPerine (black pepper), L-carnitine tartrate, CoQ10, and hawthorn extract.
The most serious interactions are with nitrates and phosphodiesterase-5 inhibitors (like sildenafil/Viagra) — both involving hawthorn — which may cause dangerous drops in blood pressure through additive vasodilation effects.
Read the full breakdown — every affected drug type, severity by severity
BioPerine can increase blood levels of several medications, including propranolol (a heart and blood pressure drug), the antiseizure drug phenytoin, the antibiotic rifampin, the antiviral nevirapine, the immune suppressant cyclosporine, the sedative pentobarbital, the cholesterol drug atorvastatin, and theophylline (used for asthma and breathing problems) — all moderate-severity interactions. L-carnitine tartrate may enhance the blood-thinning effects of warfarin and similar anticoagulants, and may reduce how well thyroid hormone replacement works.
CoQ10 may interfere with warfarin's ability to thin your blood and theoretically could protect cancer cells from certain chemotherapy drugs; it may also lower blood pressure additively with blood pressure medications (minor). Hawthorn's remaining moderate interactions include additive blood pressure and heart rate lowering with beta-blockers (heart/blood pressure drugs), increased bleeding risk with blood thinners and antiplatelet drugs, and possible potentiation of digoxin's effects and side effects.
Additionally, Etherium Pink is an ingredient we could not check because we hold no data for it.
Use the medication checker below to search your exact drugs before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against HeartLight?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in HeartLight interact with 1,179 drugs. Click any drug to see the details.
4 of the 5 ingredients in HeartLight interact with drugs. Each result below shows which ingredient is responsible. BioPerine CoQ10 Hawthorne flowers & berries extract L-Carnitine Tartrate
AvanafilStendra
How Avanafil interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorne Flowers & Berries Extract + Avanafil interactionBioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Avanafil interactionFinasteride, TadalafilEntadfi
How Finasteride, Tadalafil interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorne Flowers & Berries Extract + Finasteride, Tadalafil interactionBioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Finasteride, Tadalafil interactionGlyceryl TrinitrateNitronal
How Glyceryl Trinitrate interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorne Flowers & Berries Extract + Glyceryl Trinitrate interactionIsosorbide DinitrateAngitak, Cedocard Retard, Isoket, Isoket Retard, Isordil
How Isosorbide Dinitrate interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorne Flowers & Berries Extract + Isosorbide Dinitrate interactionIsosorbide Dinitrate, HydralazineBiDil
How Isosorbide Dinitrate, Hydralazine interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorne Flowers & Berries Extract + Isosorbide Dinitrate, Hydralazine interactionCoq10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coq10 + Isosorbide Dinitrate, Hydralazine interactionIsosorbide MononitrateAngeze, Angeze SR, Chemydur 60XL, Dynamin, Elantan, Elantan LA +13 more
How Isosorbide Mononitrate interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorne Flowers & Berries Extract + Isosorbide Mononitrate interactionMacitentan, TadalafilOpsynvi
How Macitentan, Tadalafil interacts with HeartLight — through 3 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorne Flowers & Berries Extract + Macitentan, Tadalafil interactionBioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Macitentan, Tadalafil interactionCoq10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coq10 + Macitentan, Tadalafil interactionNicorandilAprior, Dancor, Ikorel, Sigmart, Zynicor
How Nicorandil interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorne Flowers & Berries Extract + Nicorandil interactionNitroglycerinGonitro, Nitro Time, Nitro-Bid, Nitrocine Timecaps, Nitrogard, Nitrogard SR +7 more
How Nitroglycerin interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorne Flowers & Berries Extract + Nitroglycerin interactionPentaerythritol TetranitratePeritrate, Peritrate SA
How Pentaerythritol Tetranitrate interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractNitrates Major
Interaction Summary
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Read the full Hawthorne Flowers & Berries Extract + Pentaerythritol Tetranitrate interactionSildenafilRevatio
How Sildenafil interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorne Flowers & Berries Extract + Sildenafil interactionBioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Sildenafil interactionSildenafil CitrateViagra
How Sildenafil Citrate interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorne Flowers & Berries Extract + Sildenafil Citrate interactionBioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Sildenafil Citrate interactionTadalafilCialis, Tadliq
How Tadalafil interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorne Flowers & Berries Extract + Tadalafil interactionBioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Tadalafil interactionVardenafilLevitra, Staxyn
How Vardenafil interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractPhosphodiesterase-5 Inhibitors Major
Interaction Summary
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Read the full Hawthorne Flowers & Berries Extract + Vardenafil interactionBioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Vardenafil interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
BioperineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine + Abciximab interactionHawthorne Flowers & Berries ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorne Flowers & Berries Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Abemaciclib interactionAbiraterone
How Abiraterone interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorne Flowers & Berries Extract + Abrocitinib interactionBioperineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
Read the full Bioperine + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bioperine + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractBeta-blockers Moderate
Interaction Summary
Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Read the full Hawthorne Flowers & Berries Extract + Acebutolol interactionCoq10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coq10 + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with HeartLight — through 3 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorne Flowers & Berries Extract + Acenocoumarol interactionL-carnitine TartrateAcenocoumarol (sintrom) Moderate
Interaction Summary
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
Read the full L-carnitine Tartrate + Acenocoumarol interactionBioperineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
BioperineCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine + Acetaminophen, Aspirin interactionHawthorne Flowers & Berries ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorne Flowers & Berries Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with HeartLight — through 2 ingredients. Tap an ingredient for the detail:
Hawthorne Flowers & Berries ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Hawthorne Flowers & Berries Extract + Acetaminophen, Aspirin, Caffeine interactionBioperineAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Bioperine + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
Read the full Bioperine + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with HeartLight — through 1 ingredient. Tap an ingredient for the detail:
BioperineCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Bioperine + Acetaminophen, Butalbital, Codeine Phosphate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in HeartLight with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
BioPerine
Anticoagulant/Antiplatelet Drugs
Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.
Antidiabetes Drugs
Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Atorvastatin (Lipitor)
Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.
Cyclosporine (Neoral, Sandimmune)
Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.
Lithium
Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.
Nevirapine (Viramune)
Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.
P-Glycoprotein Substrates
Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.
Pentobarbital (Nembutal)
Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.
Phenytoin (Dilantin)
Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.
Propranolol (Inderal)
Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.
Rifampin (Rifadin)
Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.
Theophylline
Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.
Amoxicillin (Amoxil, Trimox)
Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.
Carbamazepine (Tegretol)
Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.
CoQ10
Alkylating Agents
Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.
Warfarin (Coumadin)
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.
Antihypertensive Drugs
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.
Hawthorne flowers & berries extract
Nitrates
Theoretically, concomitant use might cause additive coronary vasodilatory effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.
Phosphodiesterase-5 Inhibitors
Theoretically, concomitant use might result in additive vasodilation and hypotension.
Hawthorn might inhibit PDE-5 and cause vasodilation.
Anticoagulant/Antiplatelet Drugs
Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that hawthorn can inhibit platelet aggregation. However, its effect in humans is unclear. One observational study shows that patients taking hawthorn shortly before undergoing coronary artery bypass graft (CABG) surgery or valve replacement surgery have a 10% incidence of postoperative bleeding, compared with 1% in those who never consumed hawthorn extract. However, clinical research shows that taking a specific preparation of dried hawthorn leaves and flowers (Crataesor, Soria Natural Lab) 800 mg three times daily for 15 days does not affect platelet aggregation or levels of thromboxane B2, the metabolite of thromboxane A2, in healthy humans.
Beta-Blockers
Theoretically, concomitant use might cause additive effects on blood pressure and heart rate.
Some evidence shows that hawthorn might lower blood pressure and heart rate.
Calcium Channel Blockers
Theoretically, concomitant use might cause additive coronary vasodilation and hypotensive effects.
Some evidence shows that hawthorn might lower blood pressure due to vasodilatory effects.
Digoxin (Lanoxin)
Theoretically, hawthorn might potentiate the effects and adverse effects of digoxin.
Hawthorn appears to improve cardiac output; however, hawthorn does not appear to affect digoxin pharmacokinetics. Case reports suggest that at least one species of hawthorn root extract (Crataegus mexicana) may produce adverse effects similar to digoxin and can cross-react with digoxin assays, leading to falsely elevated plasma digoxin levels.
L-Carnitine Tartrate
Acenocoumarol (Sintrom)
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.
Thyroid Hormone
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.
Warfarin (Coumadin)
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.
Brand information
Manufacturer and brand details for HeartLight, from the product label.
Harmonic Innerprizes
See all Harmonic Innerprizes products- Name
- Harmonic Innerprizes, Inc.
- City
- Henderson
- State
- NV
- ZipCode
- 89053-0455
- Phone Number
- 1-888-667-4300
- Web Address
- harmonicinnerprizes.com
HeartLight by Harmonic Innerprizes: Common Questions
Does HeartLight by Harmonic Innerprizes interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take HeartLight if I'm on heart medication?
Does BioPerine actually help with anything, or is it just in here to boost absorption?
Will this help my heart?
What are the most common side effects?
Is it safe to take while pregnant?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind HeartLight’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
L-carnitine
Interacts with 19 drugsL-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...
Read the full L-carnitine monograph → Herb & supplement monographBlack Pepper
Interacts with 1,019 drugsBlack pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...
Read the full Black Pepper monograph → Herb & supplement monographHawthorn
Interacts with 191 drugsHawthorn is a plant traditionally used for heart-related complaints, and some studies suggest it may modestly help symptoms of mild heart failure when added to standard care. However, the ev...
Read the full Hawthorn monograph → Herb & supplement monographCoenzyme Q10
Interacts with 198 drugsCoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...
Read the full Coenzyme Q10 monograph →Sources & How We Checked
HeartLight's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 135 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Pepper 29 references
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L-carnitine 41 references
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- Anon. Carnitor (levocarnitine) package insert. Sigma-Tau Pharmaceuticals Inc, Gaithersburg, MD. December 1999.
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Coenzyme Q10 40 references
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