Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Hemp CBD Classic 25 mg Ingredients & Drug Interactions

by RE: Botanicals

Hemp CBD Classic 25 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hemp CBD Classic 25 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hemp CBD Classic 25 mg is a dietary supplement by RE: Botanicals with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hemp CBD Classic 25 mg by RE: Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Hemp CBD Classic 25 mg by RE: Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Hemp CBD Classic 25 mg by RE: Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

RE: Botanicals Hemp CBD Classic 25 mg is a single-ingredient liquid containing hemp aerial parts extract. The product also includes medium chain triglyceride oil as an inactive ingredient to deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hemp product and its label doesn't state a use — see Hemp's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The effectiveness data we hold for hemp aerial parts extract covers constipation, atopic dermatitis (eczema), and familial hypercholesterolemia (a genetic cholesterol disorder)—but for all these uses, the evidence isn't established well enough to rate. That doesn't mean hemp doesn't work for these or other purposes; it means the research in our files doesn't yet support a clear conclusion.

The evidence, ingredient by ingredient Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed foods are generally well tolerated in normal amounts, but concentrated extracts like this one are less studied, so caution is advised. In larger doses or extract form, side effects are uncommon, though rare serious cases—including anaphylaxis, allergic reactions (hives, facial swelling, breathing difficulty), and in one case elevated liver enzymes—have been reported.

If you're allergic to hemp seed or have a known cannabis sensitivity, be especially cautious. Pregnancy and lactation safety data aren't on file for this product, so talk with your doctor or pharmacist about whether it's right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 939 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take estrogens or hormone therapy (Moderate interaction risk), blood thinners or antiplatelet drugs, blood pressure medications, ACE inhibitors, or any drugs broken down by your liver as CYP1A2 or CYP3A4 substrates (Minor interaction risks). These interactions could make your medications less effective or increase side effects like bleeding or low blood pressure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in hemp extract, but the evidence for specific health uses isn't yet established in our data. Because it interacts with several important medication types—especially hormone therapy, blood thinners, and blood pressure drugs—you'll want to run it past your doctor or pharmacist before starting, particularly if you take any prescription medications.

It's generally well tolerated, but concentrated extracts are less studied than hemp seed foods.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hemp CBD Classic 25 mg, straight from the product label.

Brand RE: Botanicals
Barcode (UPC) 854265009007
Net contents 6 mL
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 307052
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hemp CBD Classic 25 mg by RE: Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
6
UPC/BARCODE
854265009007
IngredientAmount% DV
Calories10 Calorie(s)--
Calories from Fat10 Calorie(s)--
Total Fat1 Gram(s)2%
Saturated Fat1 Gram(s)5%
Hemp Aerial Parts Extract25 mg--

Other ingredients: Medium Chain Triglyceride Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Storage: Keep in cool, dry place, away from light.

Precautions

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition, or are taking any medication.

Keep out of reach of children.

Contains coconut

Seals/Symbols

USDA Organic

Formula

Full Spectrum 25 mg CBD/serving

FDA Statement of Identity

Dietary Supplement

Formulation

Certified organic by Pro-Cert

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hemp CBD Classic 25 mg by RE: Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hemp CBD Classic 25 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hemp CBD Classic 25 mg by RE: Botanicals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container6 Amounts shown are per serving.

Hemp Aerial Parts Extract

Interacts with
938 drugs
25 mg per serving Form: Cannabidiol

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Medium Chain Triglyceride Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hemp CBD Classic 25 mg by RE: Botanicals Drug Interactions

Want to check YOUR meds against Hemp CBD Classic 25 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
938Drugs
41 Moderate 897 Minor

Ingredients driving the most interactions

Hemp Aerial Parts Extract 938

Individual Drug Interactions

The ingredients in Hemp CBD Classic 25 mg interact with 938 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hemp CBD Classic 25 mg interact with drugs. Each result below shows which ingredient is responsible. Hemp Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hemp CBD Classic 25 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp Aerial Parts Extract6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hemp CBD Classic 25 mg, from the product label.

RE: Botanicals

See all RE: Botanicals products
Name
RE Botanicals, Inc.
City
Boulder
State
CO
ZipCode
80302
Web Address
www.REBOTANICALS.com
Pharmacist Counseling Corner

Hemp CBD Classic 25 mg by RE: Botanicals: Common Questions

Does Hemp CBD Classic 25 mg by RE: Botanicals interact with any medications?
Yes. Based on its ingredients, Hemp CBD Classic 25 mg has a known interaction with 938 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hemp CBD Classic 25 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control or hormone replacement therapy?
Hemp may interfere with how estrogens work, which is a Moderate concern. Don't start this product without talking to your doctor first—they can weigh the risks for your specific situation.
What if I take a blood thinner like warfarin?
Hemp theoretically raises bleeding risk when used with blood thinners. The data on hemp seed oil in humans suggests this may not be a major practical concern at typical doses, but your doctor or pharmacist needs to review this with you before you start.
Is this safe if I'm pregnant or breastfeeding?
We don't have safety data on file for this product during pregnancy or lactation. Talk with your doctor or pharmacist—they can give you personalized guidance based on your situation.
What does 'hemp aerial parts extract' actually mean?
Aerial parts are the above-ground parts of the hemp plant (stems, leaves, flowers). This extract concentrates those plant materials, which is why it's less studied than whole hemp seed foods.
Are there any documented side effects?
Hemp extracts are generally well tolerated. Serious side effects are rare but include allergic reactions (hives, swelling, breathing trouble) and anaphylaxis. Elevated liver enzymes have been reported in one case with very high doses. If you're allergic to hemp seed, definitely avoid this product.
Does this actually do anything?
The research we have covers a few uses—constipation, eczema, and familial hypercholesterolemia—but the evidence isn't strong enough yet to say it's effective for any of them. That doesn't rule out benefits; it just means we don't have the data to confirm them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hemp CBD Classic 25 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hemp CBD Classic 25 mg label
Go deeper

The Full Monographs Behind Hemp CBD Classic 25 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

Hemp CBD Classic 25 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team