Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Immune Edge Ingredients & Drug Interactions

by Biotivia

Immune Edge label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Immune Edge against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Immune Edge is a dietary supplement by Biotivia with 5 active ingredients. Its ingredients are commonly taken for fatigue and low energy, physical and athletic performance, stress resistance (adaptogen).Based on those ingredients, 1,254 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Siberian Ginseng, Andrographis extract, Elderberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Immune Edge by Biotivia

Ask about any prescription or over-the-counter medication and we check it for interactions with Immune Edge by Biotivia — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Immune Edge by Biotivia

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Immune Edge contains 5 active ingredients. Siberian Ginseng is an adaptogenic herb traditionally used to support energy and stress resilience.

Olive leaf extract, Elderberry extract, and Star Anise extract are plant-based ingredients often used in immune support formulas. Andrographis extract is an herb from Ayurvedic medicine that has been studied for immune and inflammatory responses.

The product contains no other inactive ingredients listed.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Immune support against seasonal infections.
  • We looked for evidence on: Common cold, Influenza, Upper respiratory tract infection (URTI), Lower respiratory tract infections, Acute bronchitis, Exercise-induced respiratory infections — and 3 related terms.
  • The closest evidence on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections (Natural Medicines).
  • Also on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Influenza.
  • Also on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Rhinosinusitis, Upper respiratory tract infection (URTI), Lower respiratory tract infections.

The evidence for most ingredients in this formula is limited or uncertain. Siberian Ginseng is possibly effective for genital herpes, though reliable evidence for other uses like chronic fatigue syndrome, bipolar disorder, and osteoporosis is insufficient.

Andrographis is possibly effective for ulcerative colitis, tonsillopharyngitis (sore throat), and osteoarthritis. For Olive leaf extract, Elderberry extract, and Star Anise extract, the data we hold shows insufficient evidence or no established effectiveness ratings for the conditions they're commonly claimed to support.

The evidence, ingredient by ingredient Eleuthero Olive Elderberry Star Anise Andrographis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Siberian Ginseng is generally well tolerated short-term, but long-term safety evidence is limited. Nervousness occurs in about 7% of users, and higher doses may cause anxiety, irritability, or mood changes.

It may raise blood pressure and heart rate, particularly in people with heart disease. Avoid it during pregnancy and breastfeeding.

Olive leaf extract appears well tolerated in supplement form, though concentrated supplements are less studied than olive oil and food olives; headache and stomach discomfort are the most common side effects. Avoid concentrated olive supplements during pregnancy and breastfeeding unless approved by your doctor.

Elderberry extracts made from cooked fruit are well tolerated; raw or unripe berries and plant parts can cause toxicity. Avoid elderberry supplements during pregnancy and breastfeeding.

Star Anise is generally safe in food amounts but concentrated supplements and teas carry safety concerns due to potential contamination and rare neurological effects. Andrographis is generally well tolerated but may cause stomach upset, headache, fatigue, rash, or rare severe allergic reactions, especially at higher doses or beyond 14 days.

Avoid it during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Eleuthero Olive Elderberry Star Anise Andrographis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Elderberry, Andrographis, Eleuthero.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,255 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Immune Edge, double-check with your doctor or pharmacist if you take digoxin (Lanoxin) for heart rhythm, blood thinners or antiplatelet drugs (Moderate severity), blood pressure medications, diabetes drugs, immunosuppressants, or the cancer drug pazopanib. Minor interactions also exist with the anti-inflammatory drugs celecoxib and etoricoxib, and the diabetes medication glipizide.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Immune Edge may appeal to people seeking herbal immune support, but it carries documented Moderate and Minor interactions with heart, blood pressure, blood-thinning, diabetes, immunosuppressant, and cancer medications. If you take any prescription drugs, especially for the heart, blood pressure, bleeding, blood sugar, or immune function, talk with your doctor or pharmacist before starting this product.

Even short-term use of Siberian Ginseng and Andrographis warrants a conversation if you have high blood pressure, heart disease, or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immune Edge, straight from the product label.

Brand Biotivia
Barcode (UPC) 094922032195
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58313
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immune Edge by Biotivia, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
094922032195
IngredientAmount% DV
Siberian Ginseng100 mg--
Olive leaf extract200 mg--
Elderberry extract100 mg--
Star Anise extract100 mg--
Andrographis extract50 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Advanced Immune Support

All Natural Immune Booster

-Powerful defender against seasonal bacterial and viral infections.* -Advanced Immune support.* -Promotes general wellbeing* -Fights bodily stress and boosts energy.* -Essential immune boost to combat flu season.*

-Manufactured in US facility in accordance with cGMP FDA regulations.

-Packaged to resist stringent heat and humidity conditions with UV

Formula

550MG

-Kosher, Halal, and Vegan certified.

-Kosher, Halal, and Vegan certified.

Seals/Symbols

AVA American Vegetarian Association

Vcaps

Brand IP Statement(s)

V-caps: vegetable hydroxypropyl methylcellulose

Formulation

Contains NO animal ingredients , fillers, silica, artificial colors, and NO Magnesium Stearate.

-Kosher, Halal, and Vegan certified.

-non-GMO, gluten-free, and preservative-free.

Suggested/Recommended/Usage/Directions

Usage Instructions: Take two capsules daily, 1 capsule in the morning and 1 capsule in the evening with water 30 minutes before meals.

Storage

Storage Instructions: Store in a cool dark place or refrigerate. Close tightly.

Precautions

WARNING: Keep out of reach of children.

Do not use if outer seal is broken or missing.

Always consult your doctor before taking any dietary supplements.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, or prevent any disease or illness.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Immune Edge by Biotivia label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Immune Edge label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Immune Edge by Biotivia

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Siberian Ginseng

Interacts with
1,140 drugs
100 mg per serving

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...

Siberian Ginseng monograph & interactions

Olive leaf extract

No known
interactions
200 mg per serving Form: Oleoperin

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive leaf extract monograph & interactions

Elderberry extract

Interacts with
121 drugs
100 mg per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Elderberry extract monograph & interactions

Star Anise extract

No known
interactions
100 mg per serving Form: Shikimic Acid

Star anise (Illicium verum) is a star-shaped spice widely used in cooking and traditional medicine, mostly for digestive and respiratory complaints. H...

Star Anise extract monograph & interactions

Andrographis extract

Interacts with
413 drugs
50 mg per serving Form: Andrographolides

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten...

Andrographis extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immune Edge by Biotivia Drug Interactions

Want to check YOUR meds against Immune Edge?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,254Drugs
821 Moderate 433 Minor

Ingredients driving the most interactions

Siberian Ginseng 1,140
Andrographis extract 413
Elderberry extract 121

Individual Drug Interactions

The ingredients in Immune Edge interact with 1,254 drugs. Click any drug to see the details.

3 of the 5 ingredients in Immune Edge interact with drugs. Each result below shows which ingredient is responsible. Siberian Ginseng Andrographis extract Elderberry extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Immune Edge with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Siberian Ginseng10 drug types · 1,140 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.

Likelihood Unlikely Evidence D
Immunosuppressants

Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.

Likelihood Possible Evidence D
Siberian Ginseng full monograph & interactions

Andrographis extract6 drug types · 413 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal and laboratory studies suggest that andrographis has antiplatelet effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Animal research suggests that andrographis has hypotensive effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.
Laboratory research suggests that andrographolide has immunostimulant activity.

Likelihood Possible Evidence D
Celecoxib (Celebrex)

Theoretically, andrographis extract might increase the maximum concentration and time to peak concentration of celecoxib. The clinical significance of these changes is unclear.
Animal research suggests that andrographis extract taken orally increases the maximum concentration and time to peak concentration of celecoxib but does not appear to impact the area under the curve.

Likelihood Possible Evidence D
Etoricoxib (Arcoxia)

Theoretically, andrographis might decrease the absorption of etoricoxib, although the clinical significance is unclear.
Animal research shows that andrographis extract, or the constituent andrographolide, taken orally with etoricoxib decreases the bioavailability of etoricoxib. However, this reduced bioavailability is not correlated with a reduction in the anti-inflammatory effects of etoricoxib in arthritic mice models. The clinical significance of this interaction is unclear.

Likelihood Possible Evidence D
Glipizide (Glucotrol)

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the constituent, andrographolide. The clinical significance of this interaction is unclear.
Animal research suggests that andrographis extract taken orally with glipizide in diabetes-induced rats increases the maximum concentration and area under the curve of glipizide. However, the opposite effect is seen with the constituent, andrographolide, in which the maximum concentration and area under the curve are decreased when taken with glipizide.

Likelihood Possible Evidence D
Andrographis extract full monograph & interactions

Elderberry extract2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Elderberry extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Immune Edge, from the product label.

Biotivia

See all Biotivia products
Name
Vitaspan, LLC
Street Address
2503 N. Harrison St. #311
City
Arlington
State
VA
ZipCode
22207
Phone Number
1-866-459-2773
Web Address
www.biotivia.com
Pharmacist Counseling Corner

Immune Edge by Biotivia: Common Questions

Does Immune Edge by Biotivia interact with any medications?
Yes. Based on its ingredients, Immune Edge has a known interaction with 1,254 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immune Edge contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Immune Edge if I'm pregnant or breastfeeding?
No. Siberian Ginseng, Elderberry, and Andrographis all advise against use during pregnancy and breastfeeding because safety data is limited or animal research raises theoretical concerns. Olive leaf extract and Star Anise extract have mixed or insufficient safety data for pregnancy and lactation. Talk with your doctor or pharmacist about whether this product is right for you at this time.
What are the most common side effects?
Siberian Ginseng may cause diarrhea, headache, nausea, upset stomach, or nervousness (in about 7% of users). Elderberry is usually well tolerated from cooked fruit. Andrographis commonly causes stomach discomfort, headache, fatigue, rash, or altered taste, especially at higher doses. Olive leaf extract may cause headache or stomach discomfort. Most side effects are mild.
Does Immune Edge actually work for colds or flu?
The evidence we have doesn't support strong effectiveness for common cold or flu. Siberian Ginseng and Elderberry lack reliable evidence for colds, flu, or lower respiratory infections. Andrographis is possibly effective for sore throat, but the overall formula hasn't been tested as a combined product for these conditions.
Can Immune Edge raise my blood pressure?
Yes, possibly. Siberian Ginseng has been reported to raise blood pressure and heart rate, especially in people with heart disease or high blood pressure. Andrographis may theoretically lower blood pressure based on animal research. If you have high blood pressure or heart disease, check with your doctor before starting.
How long is it safe to take Immune Edge?
Evidence on long-term safety is limited. Siberian Ginseng and Andrographis are generally well tolerated for short-term use, but safety beyond 14 days is not well established for Andrographis, and long-term data for Siberian Ginseng is sparse. Talk with your doctor or pharmacist about how long it's appropriate for you to take it.
What's the difference between Siberian Ginseng and other ginsengs?
Siberian Ginseng (eleuthero) is not a true ginseng but an adaptogenic herb with a different active compound profile. It's used for stress resilience and energy support, but it carries its own set of drug interactions, particularly with heart medications like digoxin, blood thinners, and diabetes drugs — so don't assume it works the same way as Asian or American ginseng.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immune Edge label
Go deeper

The Full Monographs Behind Immune Edge’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eleuthero

Interacts with 1,140 drugs

Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence behind these uses is limited and mixed, so...

Read the full Eleuthero monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph → Herb & supplement monograph

Star Anise

Star anise (Illicium verum) is a star-shaped spice widely used in cooking and traditional medicine, mostly for digestive and respiratory complaints. Human evidence for health benefits is lim...

Read the full Star Anise monograph → Herb & supplement monograph

Andrographis

Interacts with 413 drugs

Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms and shorten how long they last. The evidence is limi...

Read the full Andrographis monograph →
Sources

Sources & How We Checked

Immune Edge's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 68 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eleuthero 24 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
  3. Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
  4. Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
  5. Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
  6. Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
  7. Yun-Choi HS, Kim JH, Lee JR. Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 1987;50:1059-64. PubMed
  8. Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22.. PubMed
  9. Hartz AJ, Bentler S, Noyes R et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med 2004;34:51-61. PubMed
  10. Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V. Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides. J Am Coll Nutr 2004;23:248-58. PubMed
  11. Dasgupta A, Wu S, Actor J, et al. Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays. Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 2003;119:298-303. DOI
  12. Takahashi T, Kaku T, Sato T, et al. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. J Nat Med. 2010;64(1):55-62. PubMed
  13. Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. PubMed
  14. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  15. Molokovskii, D. S., Davydov, V. V., and Tiulenev, V. V. [The action of adaptogenic plant preparations in experimental alloxan diabetes]. Probl.Endokrinol.(Mosk) 1989;35(6):82-87.
  16. Schmolz, M. W., Sacher, F., and Aicher, B. The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytother.Res 2001;15(3):268-270.
  17. Huang, D. B., Ran, R. Z., and Yu, Z. F. [Effect of Acanthopanax senticosus injection on the activities of human tumor necrosis factor and natural killer cell in blood in the patients with lung cancer]. Zhongguo Zhong.Yao Za Zhi. 2005;30(8):621-624.
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Olive 2 references
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Elderberry 6 references
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Star Anise 10 references
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Andrographis 26 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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