Major interaction on record — check this product against your medications before combining. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Iso Lean 1 Stimfree Ingredients & Drug Interactions

by Advanced Nutrition Systems

Iso Lean 1 Stimfree label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Iso Lean 1 Stimfree against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Iso Lean 1 Stimfree is a dietary supplement by Advanced Nutrition Systems with 5 active ingredients. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 1,494 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Iso Lean 1 Stimfree by Advanced Nutrition Systems

Ask about any prescription or over-the-counter medication and we check it for interactions with Iso Lean 1 Stimfree by Advanced Nutrition Systems — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Iso Lean 1 Stimfree by Advanced Nutrition Systems

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 16 active ingredients.
  • “Thermogenic Delivery System” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Iso Lean 1 Blend” is a proprietary blend — the label gives one combined amount (1,556 mg) without saying how much of each component you get.
  • “ISO Extreme Metabolic Enhancer” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product contains 16 active ingredients designed for metabolic support and weight management. The main actives include raspberry ketones, chromium, vanadium citrate, vinpocetine, chitosan, garcinia cambogia extract, green coffee extract, green tea extract, hoodia gordonii extract, cassia nomame extract, juniper extract, dandelion extract, fennel powder, and uva ursi powder.

The inactive ingredients are gelatin, microcrystalline cellulose, magnesium stearate, titanium dioxide, and silicon dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: fat loss, appetite control, mental focus.
  • We looked for evidence on: Cognitive function, Cognitive impairment, Age-related cognitive decline, Binge eating disorder, Anxiety, Depression — and 4 related terms.
  • The closest evidence on file: Vinpocetine is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Fennel is rated "Insufficient Reliable Evidence To Rate" for Anxiety.
  • Also on file: Vanadium is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

The evidence base for most ingredients is limited. Chromium is likely effective for chromium deficiency and possibly effective for diabetes.

Green tea extract is likely effective for human papillomavirus (HPV) and possibly effective for ovarian cancer and cholesterol. Green coffee extract (caffeine) is likely effective for mental alertness and possibly effective for Parkinson disease, heart failure, diabetes, and overall mortality.

Chitosan is possibly effective for obesity and postoperative recovery. For the other ingredients — raspberry ketones, vanadium, vinpocetine, garcinia, hoodia, juniper, dandelion, fennel, and uva ursi — the data shows either insufficient evidence or possibly ineffective ratings for their intended uses in this product.

The evidence, ingredient by ingredient Chromium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 14 of the 15 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 15 of 15.
  • General safety write-ups exist for 15 of 15.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Individual ingredients have varying safety profiles. Raspberry ketone carries limited human safety data but has case reports of heart palpitations, elevated blood pressure, and dangerous arrhythmias.

Chromium is generally well tolerated at typical supplement doses, though high or long-term use may pose risks; it's considered likely safe in pregnancy and lactation at normal amounts. Vanadium is well tolerated below the tolerable upper limit of 1.8 mg daily but can cause gastrointestinal side effects at higher doses and kidney damage with long-term high doses; avoid it in pregnancy.

Vinpocetine is generally well tolerated short-term but carries a pregnancy warning from the FDA — it's possibly unsafe. Chitosan is generally well tolerated short-term but lacks safety data in pregnancy and lactation.

Garcinia is generally well tolerated but has rare reports of liver injury, heart inflammation, and mania; avoid in pregnancy and lactation. Green coffee and green tea extracts can cause caffeine-related side effects; limit during pregnancy and keep caffeine intake low while breastfeeding.

Hoodia, juniper, dandelion, fennel, and uva ursi all lack sufficient pregnancy safety data — avoid them during pregnancy. Most of these ingredients can cause gastrointestinal upset (constipation, diarrhea, nausea, stomach discomfort).

Side effects, ingredient by ingredient Chromium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 14 of the 15 matched ingredients can interact with medications — Vinpocetine, Fennel, Uva Ursi, Chitosan, Phaseolus Vulgaris, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,495 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take ephedrine (Major risk), nadolol or atorvastatin (Major risk), blood thinners or antiplatelet drugs, diabetes medications, heart or blood pressure medications, antidepressants, or seizure medications. The product contains caffeine equivalents that can interact with multiple drugs and affect how your body clears them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

If you're taking any prescription medication — especially for heart rate, blood pressure, cholesterol, blood clotting, diabetes, or mental health — check your exact drugs with the tool on this page before using Iso Lean 1 Stimfree. The high caffeine content and multiple stimulant-like ingredients make this risky with certain medications.

If you're pregnant, breastfeeding, or planning pregnancy, talk with your pharmacist first; several ingredients carry safety cautions for these situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 15 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Iso Lean 1 Stimfree, straight from the product label.

Brand Advanced Nutrition Systems
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 180517
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Iso Lean 1 Stimfree by Advanced Nutrition Systems, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Raspberry Ketones0 NP--
Chromium60 mcg50%
Vanadium Citrate0 NP--
Medium Chain Triglycerides powder0 NP--
Vinpocetine0 NP--
Chitosan0 NP--
Thermogenic Delivery System0 NP--
Iso Lean 1 Blend1556 mg--
ISO Extreme Metabolic Enhancer0 NP--
Garcinia cambogia extract0 NP--
Green Coffee (Coffea robusta) extract0 NP--
Green Tea (Camelia sinensis) extract0 NP--
Carb Blocked Anti-Appetite Blend0 NP--
White Kidney Bean (Phaseolus vulgaris) extract0 NP--
Hoodia gordonii extract0 NP--
Cassia nomame extract0 NP--
Hydro Cut Blend0 NP--
Juniper (Juniperus communis) extract0 NP--
Dandelion (Taraxacum officinale) extract0 NP--
Fennel (Foeniculum vulgare) powder0 NP--
Uva Ursi (Arctostaphylos uva-ursi) powder0 NP--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Iso Lean 1 All bodies are not created equal A premier metabolic enhancer that destroys fat, controls appetite, and improves mental focus without harsh stimulants.

Thermogenic

Metabolism Energy Appetite

Please recycle.

Made in the USA Proudly made in the USA with carefully selected ingredients of international and domestic origin.

Formulation

A premier metabolic enhancer that destroys fat, controls appetite, and improves mental focus without harsh stimulants.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 1 capsule with 8 oz of water in the morning, and 1 capsules with 8 oz of water in the afternoon. Do not take more than 1 serving daily. Please read the entire label before use.

Precautions

Do not take more than 1 serving daily. Please read the entire label before use.

This product was produced in a facility that may also process ingredients containing milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans.

Warning: Do not use if pregnant, nursing, or plan on becoming pregnant.

This product is intended for use by healthy adults over the age of 18 and should be avoided by those sensitive to caffeine or other ingredients that have known stimulant effects. Do not use this product continuously for more than 8 weeks. Do not combine with alcohol. Not intended for use by those with a medical condition. Use only as directed. Do not exceed recommended daily intake.

Consult a physician or licensed qualified health care professional prior to use if you are pregnant or nursing, or if you are taking medication, including, but not limited to MAO inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, or other stimulants, or if you have a medical condition, including, but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate, or glaucoma.

Discontinue 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. Do not use if safety seal under cap is broken.

Keep out of reach of children.

Brand IP Statement(s)

KSM-66 is a registered trademark of Ixoreal Biomed Private Limited.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Iso Lean 1 Stimfree by Advanced Nutrition Systems label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Iso Lean 1 Stimfree label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Iso Lean 1 Stimfree by Advanced Nutrition Systems

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chromium

Interacts with
178 drugs
60 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Iso Lean 1 Blend

1556 mg per serving
  • › Thermogenic Delivery System
  • › ISO Extreme Metabolic Enhancer
  • › Carb Blocked Anti-Appetite Blend
  • › Hydro Cut Blend

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Iso Lean 1 Stimfree by Advanced Nutrition Systems Drug Interactions

Want to check YOUR meds against Iso Lean 1 Stimfree?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,494Drugs
13 Major 1,446 Moderate 35 Minor

Ingredients driving the most interactions

Chromium 178

Individual Drug Interactions

The ingredients in Iso Lean 1 Stimfree interact with 1,494 drugs. Click any drug to see the details.

1 of the 5 ingredients in Iso Lean 1 Stimfree interact with drugs. Each result below shows which ingredient is responsible. Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Iso Lean 1 Stimfree with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Iso Lean 1 Stimfree, from the product label.

Advanced Nutrition Systems

See all Advanced Nutrition Systems products
Name
Advanced Nutrition Systems
Pharmacist Counseling Corner

Iso Lean 1 Stimfree by Advanced Nutrition Systems: Common Questions

Does Iso Lean 1 Stimfree by Advanced Nutrition Systems interact with any medications?
Yes. Based on its ingredients, Iso Lean 1 Stimfree has a known interaction with 1,494 medications, including 13 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Iso Lean 1 Stimfree contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this work for weight loss?
The evidence is mixed. Chitosan is possibly effective for obesity, but most other ingredients — including garcinia, hoodia, and raspberry ketones — have insufficient evidence or are possibly ineffective. The data we hold doesn't support strong claims about this product's effectiveness for weight management.
Can I take this if I'm on a blood thinner like warfarin?
No — you need to talk to your pharmacist first. Raspberry ketone, vanadium, chitosan, garcinia, and green tea all interact with blood thinners at Moderate severity and may increase bleeding risk. Your pharmacist or doctor needs to monitor you closely or adjust your medication.
Is it safe during pregnancy?
No. Vinpocetine carries an FDA warning against use in pregnancy. Vanadium, garcinia, hoodia, juniper, dandelion, and fennel all lack sufficient safety data and should be avoided. Chromium in normal amounts is likely safe, but check with your doctor before using any supplement in pregnancy.
What are the most common side effects I might feel?
Gastrointestinal upset — nausea, diarrhea, constipation, stomach discomfort — is the most common complaint. Caffeine-related effects (jitteriness, anxiety, insomnia, headache) are also possible. Raspberry ketone structurally resembles a stimulant and has caused heart palpitations and elevated blood pressure in case reports.
Can I take this with my diabetes medication?
Potentially, but only with close monitoring by your doctor or pharmacist. Chromium, vanadium, garcinia, hoodia, juniper, and dandelion all theoretically increase the risk of low blood sugar when combined with diabetes drugs. Your blood sugar levels need to be watched, and your diabetes medication dose may need adjustment.
Does this contain any stimulants?
Not prescription stimulants, but yes — green coffee extract contains caffeine, and raspberry ketone structurally resembles the stimulant synephrine. The product is labeled 'stimfree' but still carries stimulant-like effects and risks, especially with ephedrine or other stimulant drugs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Iso Lean 1 Stimfree is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Iso Lean 1 Stimfree label
Go deeper

The Full Monographs Behind Iso Lean 1 Stimfree’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph →
Sources

Sources & How We Checked

Iso Lean 1 Stimfree's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 630 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Raspberry Ketone 4 references
  1. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  2. Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  3. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
  4. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

See these in context on the Raspberry Ketone monograph →

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
  20. Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
  21. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
  22. John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
  23. Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
  24. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  25. Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
  26. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Lung cancer among workers in chromium chemical production. Am J Ind.Med 2000;38(2):115-126. DOI
  27. Gibb, H. J., Lees, P. S., Pinsky, P. F., and Rooney, B. C. Clinical findings of irritation among chromium chemical production workers. Am J Ind.Med 2000;38(2):127-131. PubMed
  28. Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536. PubMed
  29. Pei, D., Hsieh, C. H., Hung, Y. J., Li, J. C., Lee, C. H., and Kuo, S. W. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism 2 PubMed
  30. Hisatomi, K., Ishii, H., Hashiguchi, K., Seki, M., Ide, M., Sugiyama, K., Ishimoto, H., Nakayama, S., Mukae, H., and Kohno, S. Interstitial pneumonia caused by inhalation of fumes of nickel and chrome. Respirology. 2006;11(6):814-817. PubMed
  31. Kleefstra, N., Houweling, S. T., Bakker, S. J., Verhoeven, S., Gans, R. O., Meyboom-de Jong, B., and Bilo, H. J. Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled tri DOI
  32. Parsons, A., Ingram, J., Inglis, J., Aveyard, P., Johnstone, E., Brown, K., Franklin, M., and Bermudez, I. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to pr
  33. Bagdon RE and Hazen RE. Skin permeation and cutaneous hypersensitivity as a basis for making risk assessments of chromium as a soil contaminant. Environ.Health Perspect. 1991;92:111-119. PubMed
  34. Bharmal, S. V., Moyes, V., Ahmed, S., and Grossman, A. Hypoglycaemia: possible mediation by chromium salt medication. Hormones.(Athens.) 2010;9(2):181-183. PubMed
  35. Krol, E., Krejpcio, Z., Byks, H., Bogdanski, P., and Pupek-Musialik, D. Effects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patients. Biol.Trace Elem.Res. 2011;143(2):726-737.
  36. Unisa, S., Jagannath, P., Dhir, V., Khandelwal, C., Sarangi, L., and Roy, T. K. Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB (Oxford) 2011;13(2):117-125. PubMed
  37. Noda, S., Asano, Y., and Sato, S. Lichen planus in a patient with long-term exposure to chrome. Eur.J.Dermatol. 2011;21(3):417-418. PubMed
  38. Xiang, J., Sun, Z., and Huan, J. N. Intensive chromic acid burns and acute chromium poisoning with acute renal failure. Chin Med.J.(Engl.) 7-5-2011;124(13):2071-2073.
  39. Chhabra, D., Oda, K., Jagannath, P., Utsunomiya, H., Takekoshi, S., and Nimura, Y. Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac.J.Cancer Prev. 2012;13(1):187-190. PubMed
  40. Huszonek, J. Over-the-counter chromium picolinate. Am J Psychiatry 1993;150(10):1560-1561. PubMed
  41. Bunner S and McGinnis R. Chromium-induced hypoglycemia. Psychosomatics 1998;39(3):298-299. PubMed
  42. Martin, W. R. and Fuller, R. E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 1998;18(4):860-862. DOI
  43. Proctor, D. M., Fredrick, M. M., Scott, P. K., Paustenbach, D. J., and Finley, B. L. The prevalence of chromium allergy in the United States and its implications for setting soil cleanup: a cost-effectiveness case study. Regul.Toxicol Pharmacol 1998;28(1 PubMed
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See these in context on the Coffee monograph →

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Fennel 17 references
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  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
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Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
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See these in context on the Uva Ursi monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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