Lithium Orotate Ingredients & Drug Interactions
by Klaire Labs
What is this page for?
First and foremost: checking Lithium Orotate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lithium Orotate is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for mood support, bipolar disorder (prescription), healthy mental function.Based on those ingredients, 515 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lithium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lithium Orotate by Klaire Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with Lithium Orotate by Klaire Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lithium Orotate by Klaire Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: lithium, a mineral element used in prescription form to treat bipolar disorder and certain other conditions. The supplement form delivers much smaller doses than prescription lithium and is not formulated for the same medical uses.
The capsule is filled with inactive ingredients — microcrystalline cellulose, hydroxypropylmethylcellulose, and water — which serve as binders and fillers.
Does it work?
Couldn't assess
The evidence we hold on lithium for alcohol use disorder, Alzheimer disease, ALS (amyotrophic lateral sclerosis), and anorexia nervosa is insufficient to establish whether it works for these uses. Lithium is well established for prescription treatment of bipolar disorder, but the safety and effectiveness of the lower supplement doses for any condition aren't well studied in the data we have.
How safe is it?
Well-documented data
Prescription lithium is generally well tolerated when monitored, but it has a very narrow safety margin — blood levels must be tracked to prevent toxicity. The supplement form isn't well studied, so how the lower doses affect side effects is unclear.
Common effects from prescription lithium include tremor, fatigue, muscle weakness, weight gain, increased thirst and urination, and gastrointestinal upset. Lithium can also worsen skin disorders like acne and psoriasis, and rarely cause Stevens-Johnson syndrome (a severe skin reaction).
Lithium crosses the placenta and has been linked to birth defects, so it's rated possibly unsafe in pregnancy — avoid unless your doctor directs and monitors it. It passes into breast milk and may harm an infant, so it's rated likely unsafe while breastfeeding.
If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product. Additionally, if you've been taking lithium and stop suddenly, bipolar symptoms can flare; lithium should be tapered gradually over at least 14 days.
Meds to double-check
Major interaction found
Before taking Lithium Orotate, double-check with your doctor or pharmacist if you're on serotonergic drugs (SSRIs, SNRIs, or other antidepressants) — risk of serotonin syndrome. Also check if you take diuretics (water pills), muscle relaxants, NSAIDs (ibuprofen, naproxen), ACE inhibitors, calcium channel blockers, antipsychotics, or anticonvulsants.
Altogether, these interactions span 515 individual medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Lithium Orotate carries major interaction risks with serotonergic drugs (antidepressants like SSRIs) and diuretics, and moderate risks with several blood pressure and heart medications, muscle relaxants, pain relievers, and anticonvulsants. Because lithium has such a narrow safety window, this isn't a supplement to take casually or without guidance.
If you take any prescription medication, are pregnant, breastfeeding, or have bipolar disorder or depression, talk with your doctor or pharmacist before starting this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lithium Orotate, straight from the product label.
| Brand | Klaire Labs |
|---|---|
| Barcode (UPC) | 817234011722 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 281114 |
| Product type | Mineral |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lithium Orotate by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lithium | 4.8 mg | -- |
Other ingredients: Microcrystalline Cellulose, Hydroxypropylmethylcellulose, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Free of the following common allergens: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives.
Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 capsule, 2 times daily with food or as directed by a healthcare professional.
Precautions
Do not use if shrinkwrap is broken or missing.
Caution: Individuals with renal or cardiovascular disease or who are taking diuretics or ACE inhibitors should consult their healthcare professional before use.
Lithium should not be used by pregnant or nursing women. If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.
Keep out of reach of children.
Storage
Store in a cool, dry place (59 F - 85 F) away from direct light.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
SFI
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lithium Orotate by Klaire Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lithium Orotate by Klaire Labs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Lithium
Interacts with515 drugs
Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment for bipola...
Lithium monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropylmethylcellulose, Water. These complete the product’s ingredient list but are not active constituents.
Lithium Orotate by Klaire Labs Drug Interactions
HelloPharmacist Interaction Report
Klaire Labs Lithium Orotate contains lithium, which interacts with a broad range of medications.
The most serious concerns are serotonergic drugs (like SSRIs and SNRIs) — taking lithium with these can both mask and increase the risk of serotonin syndrome, a potentially dangerous condition. Diuretics (water pills) are equally critical: they can raise lithium levels to unsafe heights, especially loop and thiazide types.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions affect several other drug classes. Muscle relaxants may prolong neuromuscular blockade.
NSAIDs, ACE inhibitors (blood pressure and heart drugs), and calcium channel blockers can all raise lithium levels or create other adverse effects. Antipsychotics carry a risk of encephalopathic syndrome — confusion, weakness, fever, and movement problems — when combined with lithium.
Anticonvulsants may increase neurotoxicity risk. It's unclear whether the lower doses in supplements trigger these interactions as readily as prescription lithium does, but the potential is real.
Although we hold data on lithium's interactions, many other ingredients in combination products aren't well studied for interactions. Before taking this supplement, check your exact medications with the search tool on this page or talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lithium Orotate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lithium Orotate interact with 515 drugs. Click any drug to see the details.
1 of the 1 ingredient in Lithium Orotate interact with drugs. Each result below shows which ingredient is responsible. Lithium
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumMethylxanthines, Diuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Read the full Lithium + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Meperidine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs, Anticonvulsants Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Acetazolamide interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Alosetron interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumDiuretic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Amiloride, Hydrochlorothiazide interactionAmitriptylineElavil
How Amitriptyline interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Lithium Orotate — through 1 ingredient. Tap an ingredient for the detail:
LithiumSerotonergic Drugs Major
Interaction Summary
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
Read the full Lithium + Amitriptyline, Chlordiazepoxide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lithium Orotate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Lithium
Diuretic Drugs
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Thiazide diuretics and loop diuretics might reduce lithium excretion, particularly in sodium-restricted patients. If lithium is clinically indicated and other treatment options are unavailable or inadequate in patients using diuretics, lithium treatment can be initiated with extreme caution. Serum lithium should be measured frequently and the doses used should be the lowest dose ordinarily tolerated. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Serotonergic Drugs
Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.
In a case report, a 67-year-old female with depression and bipolar disorder using lithium in combination with selective serotonin reuptake inhibitors (SSRIs) and other medications developed serotonin syndrome with symptoms of deep tendon hyperreflexia, muscle rigidity, tremor, and hyperthermia. However, agitation, one classical symptom of serotonin syndrome, was lacking. This was thought to be due to masking by lithium toxicity. Lithium can increase serotonin levels, thus, combining serotonergic drugs with lithium might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Ace Inhibitors (Aceis)
Theoretically, taking lithium supplements with ACEIs might increase levels and adverse effects of lithium.
Concomitant administration of ACEIs with lithium may increase lithium concentrations. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Anticonvulsants
Theoretically, taking lithium supplements with anticonvulsants might increase the risk of neurotoxicity.
Drugs such as carbamazepine and phenytoin seem to increase the risk of neurotoxicity. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Antipsychotic Drugs
Theoretically, taking lithium supplements with antipsychotic drugs might increase the risk of encephalopathic syndrome.
Encephalopathic syndrome has been reported in multiple patients taking prescription lithium and antipsychotics concomitantly. Symptoms have included weakness and lethargy, fever, confusion, and extrapyramidal symptoms. In some patients, resulting brain damage was irreversible. Although there is no established causal relationship between these symptoms and the combination of lithium and antipsychotic medications, there is a theoretical relationship. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Calcium Channel Blockers
Theoretically, taking lithium supplements with calcium channel blockers might reduce lithium levels and might also increase the risk of certain adverse effects.
Calcium channel blockers might reduce lithium concentrations. Monitor lithium levels with concurrent use. Calcium channel blockers might also increase the adverse neurological and gastrointestinal adverse effects of lithium. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Methyldopa (Aldomet)
Theoretically, taking lithium supplements with methyldopa might increase the risk of lithium toxicity.
Concurrent use of methyldopa with lithium increases the risk of lithium toxicity. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Methylxanthines
Theoretically, taking lithium supplements with methylxanthines might decrease lithium levels.
Xanthines such as aminophylline, caffeine, and theophylline (Theo-Dur, Theo-24, others) might increase the clearance of lithium. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.
NSAIDs can decrease the renal clearance of lithium and increase lithium levels. It is unclear if this interaction would be clinically significant with the smaller doses found in lithium supplements.
Phenothiazines
Theoretically, taking lithium supplements with phenothiazines might decrease the levels and clinical effects of phenothiazines.
Concomitant use of lithium with phenothiazines might reduce lithium concentrations. Lithium might also reduce phenothiazine concentrations, making the pharmacokinetic effect unpredictable. It is unclear if these interactions would occur with the smaller doses found in lithium supplements.
Skeletal Muscle Relaxants
Theoretically, taking lithium supplements with skeletal muscle relaxants might prolong neuromuscular blockade.
Lithium might prolong neuromuscular blockade. It is unclear if this interaction would occur with the smaller doses found in lithium supplements.
Brand information
Manufacturer and brand details for Lithium Orotate, from the product label.
Klaire Labs
See all Klaire Labs products- Name
- SFI USA
- City
- Reno
- State
- NV
- ZipCode
- 89521
- Web Address
- Klaire.com
Lithium Orotate by Klaire Labs: Common Questions
Does Lithium Orotate by Klaire Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to take lithium supplements if I'm on an antidepressant?
What are the common side effects from lithium supplements?
Can I take this supplement while pregnant or breastfeeding?
Does this supplement actually work for anything?
Why does lithium require blood monitoring when it's prescribed?
If I've been taking lithium, can I just stop?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lithium Orotate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lithium Orotate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Lithium Orotate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lithium 26 references
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
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