Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Mobility Ingredients & Drug Interactions

by GNC TriFlex

Mobility label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mobility against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mobility is a dietary supplement by GNC TriFlex with 3 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Apres-Flex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mobility by GNC TriFlex

Ask about any prescription or over-the-counter medication and we check it for interactions with Mobility by GNC TriFlex — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mobility by GNC TriFlex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GNC TriFlex Mobility contains three active ingredients. Hyaluronic acid is a naturally occurring substance that helps retain moisture in tissues; the second ingredient, Fast-Acting Mobility Blend, is proprietary and we have no breakdown of what it contains.

The third is Apres-Flex, which is Boswellia serrata (also called Indian frankincense), a resin extract traditionally used to support joint comfort. The product also includes several inactive ingredients — fillers and binders like dicalcium phosphate, cellulose, and vegetable acetoglycerides, plus titanium dioxide for color and sodium copper chlorophyllin for coloring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: improves joint movement and flexibility.
  • We looked for evidence on: Osteoarthritis, Knee pain, joint stiffness, joint mobility.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Knee pain.
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.

Hyaluronic acid is possibly effective for dry eye and venous leg ulcers (slow-healing wounds on the legs). For aging skin, hay fever, and sexual dysfunction, the evidence we hold is not strong enough to rate it.

Boswellia serrata is possibly effective for osteoarthritis. For hay fever, Alzheimer disease, asthma, and cluster headache, we don't have reliable evidence yet.

The effectiveness of Fast-Acting Mobility Blend is not established in the data we hold.

The evidence, ingredient by ingredient Hyaluronic Acid Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hyaluronic acid is generally well tolerated when taken by mouth or applied to skin, though long-term safety of supplements hasn't been fully studied. The safety notes caution that oral hyaluronic acid supplements should be avoided unless your doctor advises otherwise, because information is limited.

Boswellia serrata is generally well tolerated short-term, but quality and dose vary widely between products. The most common side effects are abdominal pain, diarrhea, headache, heartburn, itching, and nausea.

Dizziness and vertigo have also been reported in some people. A rare serious effect is bezoar formation (a mass in the stomach) if very large amounts are taken.

For pregnancy and breastfeeding, there isn't enough safety data for hyaluronic acid, and the advice is to avoid oral supplements unless your doctor clears it. Boswellia should be avoided during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Hyaluronic Acid Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GNC TriFlex Mobility, ask your pharmacist or doctor whether you take any medications processed through your liver's CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 enzyme systems — this includes many antidepressants, heart medications, blood thinners, statins, and immunosuppressants. Boswellia may raise the blood levels of these drugs.

Additionally, if you take immunosuppressive medications (used after transplant or for autoimmune conditions), Boswellia might alter how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GNC TriFlex Mobility may help with joint comfort or dry eye, but it carries Moderate-severity interactions with a very large number of medications through its Boswellia ingredient. If you take any prescription medications — especially those for heart rhythm, blood pressure, mood, blood thinning, or immune suppression — you need to check them against the interaction tool on this page before starting.

Pregnant or breastfeeding people should avoid this product unless their doctor advises otherwise. Talk with your own doctor or pharmacist before adding this to your routine, especially if you're on any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mobility, straight from the product label.

Brand GNC TriFlex
Barcode (UPC) 048107118655
Net contents 60 Caplet(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 19436
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mobility by GNC TriFlex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
Servings per container
30
UPC/BARCODE
048107118655
IngredientAmount% DV
Hyaluronic Acid5 mg--
Fast-Acting Mobility Blend250 mg--
Apres-Flex100 mg--

Other ingredients: Dicalcium Phosphate, Cellulose, Titanium Dioxide, Vegetable Acetoglycerides, Sodium Copper Chlorophyllin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

ApresFlex(R) is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas - Laila Nutra LLC. International patents pending.

*In a 30 day, randomized, double-blind, placebo-controlled study of 67 adults, subjects taking 50 mg/day of ApresFlex(R) twice daily experienced a statistically significant difference in mean improvements from baseline for joint comfort, stiffness and function as measured by WOMAC that was 7, 5, and 43 times greater in the ApresFlex(R) group than placebo, respectively, after 30 days. Statistically significant improvements were seen as early as 5 days. ^In a 12 week, multi-center, randomized, double-blind, placebo-controlled study of 60 adults, subjects taking 250 mg/day of the GNC TriFlex(TM) Fast-Acting Mobility Blend showed statistically significant improvements in measures of joint function and joint flexibility within 30 days compared to subjects on placebo.

General Statements

-Improves joint movement in just 5 days** -5 times greater improvement in joint stiffness** -Enhances flexibility by 30% with just two small pills per day^*

67% SMALLER PILL*

*Compared to a leading brand.

Suggested/Recommended/Usage/Directions

TWO PER DAY

Directions: As a dietary supplement, take two caplets daily. For best results, take one caplet twice daily.

General

CODE 282312 GNG

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mobility by GNC TriFlex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mobility label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mobility by GNC TriFlex

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hyaluronic Acid

No known
interactions
5 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Fast-Acting Mobility Blend

250 mg per serving Form: Acacia catechu wood and bark extract, Chinese Skullcap root extract

Apres-Flex

Interacts with
952 drugs
100 mg per serving

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

Apres-Flex monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Cellulose, Titanium Dioxide, Vegetable Acetoglycerides, Sodium Copper Chlorophyllin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mobility by GNC TriFlex Drug Interactions

Want to check YOUR meds against Mobility?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

Apres-Flex 952

Individual Drug Interactions

The ingredients in Mobility interact with 952 drugs. Click any drug to see the details.

1 of the 3 ingredients in Mobility interact with drugs. Each result below shows which ingredient is responsible. Apres-Flex

Each ingredient & the kinds of drugs it affects

For each ingredient in Mobility with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Apres-Flex6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Apres-Flex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mobility, from the product label.

GNC TriFlex

Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Mobility by GNC TriFlex: Common Questions

Does Mobility by GNC TriFlex interact with any medications?
Yes. Based on its ingredients, Mobility has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mobility contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for joint pain?
Boswellia serrata (one of the active ingredients) is possibly effective for osteoarthritis. Hyaluronic acid's role in joint health isn't established in our data. Fast-Acting Mobility Blend's effectiveness is unknown because we have no data on what it contains.
Can I take this while pregnant or breastfeeding?
No. Boswellia serrata should be avoided during pregnancy and breastfeeding. Hyaluronic acid also lacks enough safety data, so oral supplements should be avoided unless your doctor advises otherwise. Talk with your doctor or pharmacist about whether this product is right for you.
What are the most common side effects?
From Boswellia serrata, the most common side effects are abdominal pain, diarrhea, headache, heartburn, itching, and nausea. Dizziness and vertigo have also been reported. Hyaluronic acid is generally well tolerated when taken by mouth, with rare reports of eye discomfort from eye drops.
What is hyaluronic acid and why is it in this product?
Hyaluronic acid is a naturally occurring substance that helps tissues retain moisture. It's possibly effective for dry eyes and slow-healing wounds on the legs. In a mobility product, it may support joint lubrication, though we don't have strong evidence for that use.
Why do I need to check my medications before taking this?
Boswellia serrata can slow down how your liver breaks down many common drugs — blood pressure medications, antidepressants, statins, blood thinners, and others — which may cause their levels to rise and side effects to worsen. You need to run your exact prescriptions through the checker on this page before starting.
What is Apres-Flex?
Apres-Flex is Boswellia serrata, a resin from a tree traditionally used in Ayurvedic medicine. It's possibly effective for osteoarthritis and generally well tolerated short-term, though abdominal side effects and headaches can occur.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mobility label
Go deeper

The Full Monographs Behind Mobility’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Mobility's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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