Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Re-Leaf Ingredients & Drug Interactions

by Red Moon Herbs

Re-Leaf label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Re-Leaf against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Re-Leaf is a dietary supplement by Red Moon Herbs with 4 active ingredients. Its ingredients are commonly taken for menstrual cramps, muscle spasms, general cramping pain.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce, Fresh, California Poppy, Fresh. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Re-Leaf by Red Moon Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Re-Leaf by Red Moon Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Re-Leaf by Red Moon Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Re-Leaf is a liquid supplement with 4 active ingredients: Cramp Bark, California Poppy (Fresh), Pedicularis (Fresh), and Wild Lettuce (Fresh) — the first three are blended in a proprietary formula. California Poppy and Wild Lettuce are traditionally used for their calming properties, while Cramp Bark has a history in folk medicine for muscle-related concerns.

The liquid also contains alcohol and water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Relaxation, sleep support, and muscle tension relief.
  • We looked for evidence on: Anxiety, Insomnia, Muscle cramps, Dysmenorrhea, Nocturnal enuresis, Stress — and 3 related terms.
  • The closest evidence on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Nocturnal enuresis.
  • Also on file: Cramp Bark is rated "Insufficient Reliable Evidence To Rate" for Muscle cramps, Dysmenorrhea.

The evidence supporting these ingredients is limited. For Cramp Bark, we hold insufficient reliable evidence to rate its use for muscle cramps, kidney stones, dysmenorrhea (period pain), or pregnancy-related leg cramps.

California Poppy similarly has insufficient reliable evidence for anxiety or insomnia. Wild Lettuce has no effectiveness ratings on file in our data.

This doesn't mean the product doesn't work — it means the clinical evidence we have access to isn't strong enough to make a confident claim either way.

The evidence, ingredient by ingredient Cramp Bark California Poppy Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for these ingredients are limited, and all three checked active ingredients carry caution or avoidance notices for pregnancy and breastfeeding. Cramp Bark, California Poppy, and Wild Lettuce are all best avoided during pregnancy and breastfeeding due to insufficient safety information.

California Poppy has been reported to cause muscular stiffness, morning fatigue, and nausea when combined with hawthorn and magnesium, though it's unclear which ingredient caused which effect. Wild Lettuce at high doses can cause sweating, dizziness, rapid heartbeat, vision problems, and more serious effects; topical contact with wild lettuce may cause skin irritation.

Because this is a liquid with alcohol, also note that alcohol content may interact with certain medications or health conditions.

Side effects, ingredient by ingredient Cramp Bark California Poppy Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — California Poppy, Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Re-Leaf, check if you're on any CNS depressants (Moderate severity) — that's sedating drugs like sleeping pills, anti-anxiety medications, pain relievers with sedative effects, or any other drugs that make you drowsy. Also flag any anticholinergic drugs (Moderate severity) you're taking, since Wild Lettuce may contain trace amounts of an anticholinergic compound.

One ingredient, Pedicularis, could not be checked against our medication database.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Re-Leaf is best suited for people interested in traditional herbal support for occasional muscle tension or relaxation who don't take sedating medications or anticholinergic drugs. If you're on any prescription or over-the-counter medications — especially anything that makes you drowsy — check your exact drugs with the tool on this page before starting.

Pregnant or breastfeeding? Talk to your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Re-Leaf, straight from the product label.

Brand Red Moon Herbs
Barcode (UPC) 850001442299
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319315
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All), Women (not pregnant or lactating), Infants/Baby (0 - 1 Year), Seniors/Mature (>50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Re-Leaf by Red Moon Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
50 Drop(s)
Maximum serving Sizes:
75 Drop(s)
UPC/BARCODE
850001442299
IngredientAmount% DV
Proprietary Blend0 NP--
Cramp Bark0 NP--
California Poppy, Fresh0 NP--
Pedicularis, Fresh0 NP--
Wild Lettuce, Fresh0 NP--

Other ingredients: Alcohol, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake well. Take 50-75 drops 1-3 times daily in a little water.

Precautions

Not for use while pregnant.

General Statements

Red Moon Herbs Est. 1994 Still made the wise woman way

FDA Statement of Identity

Dietary Supplement

Formula

Fresh Appalachian extracts for the whole family

Formulation

Fresh Appalachian extracts for the whole family

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Re-Leaf by Red Moon Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Re-Leaf label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Re-Leaf by Red Moon Herbs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size50 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: Alcohol, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Re-Leaf by Red Moon Herbs Drug Interactions

Want to check YOUR meds against Re-Leaf?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce, Fresh 393
California Poppy, Fresh 248

Individual Drug Interactions

The ingredients in Re-Leaf interact with 393 drugs. Click any drug to see the details.

2 of the 4 ingredients in Re-Leaf interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce, Fresh California Poppy, Fresh

Each ingredient & the kinds of drugs it affects

For each ingredient in Re-Leaf with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce, Fresh2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce, Fresh full monograph & interactions

California Poppy, Fresh1 drug type · 248 drugs

Cns Depressants

Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.
Laboratory research shows that California poppy has sedative effects.

Likelihood Possible Evidence D
California Poppy, Fresh full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Re-Leaf, from the product label.

Red Moon Herbs

See all Red Moon Herbs products
Name
Red Moon Herbs
City
Asheville
State
NC
Phone Number
888-929-0777
Web Address
redmoonherbs.com
Pharmacist Counseling Corner

Re-Leaf by Red Moon Herbs: Common Questions

Does Re-Leaf by Red Moon Herbs interact with any medications?
Yes. Based on its ingredients, Re-Leaf has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Re-Leaf contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Re-Leaf if I'm pregnant or breastfeeding?
The safety data advise against it. All three active ingredients we checked — Cramp Bark, California Poppy, and Wild Lettuce — are best avoided during pregnancy and breastfeeding because there isn't enough safety information. Talk to your doctor or pharmacist about whether this product is right for you.
Will Re-Leaf help with muscle cramps?
Cramp Bark has a long history in traditional medicine for that purpose, but we don't have enough reliable clinical evidence to say whether it works. The same goes for the other ingredients — the evidence just isn't established in the data we hold.
Is this safe to use long-term?
Human safety data for these ingredients are limited, especially with extended use. The facts note that California Poppy is generally considered mild for short-term use, and Wild Lettuce carries caution because high doses have been linked to side effects. Check with your pharmacist about how long you're planning to use it.
What are the side effects of California Poppy in this product?
When California Poppy was used in studies combined with hawthorn and magnesium, some people reported muscular stiffness, morning fatigue, and nausea — though it's unclear whether California Poppy itself caused these effects or the combination did. Overall, adverse effect information for California Poppy alone is limited.
What happens if I take too much Wild Lettuce?
At large doses, wild lettuce has been reported to cause sweating, dizziness, rapid heartbeat, vision problems, ringing in the ears, headache, and in severe cases, coma. The product is a liquid, so measure doses carefully and don't exceed the label recommendation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Re-Leaf label
Go deeper

The Full Monographs Behind Re-Leaf’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cramp Bark

Cramp Bark is the dried bark of Viburnum opulus, traditionally used to ease muscle and menstrual cramps. Modern, high-quality human studies are very limited, so its effectiveness is not well...

Read the full Cramp Bark monograph → Herb & supplement monograph

California Poppy

Interacts with 248 drugs

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are...

Read the full California Poppy monograph → Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Re-Leaf's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

California Poppy 3 references
  1. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  2. Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
  3. Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

See these in context on the California Poppy monograph →

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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