SAMe 200 Ingredients & Drug Interactions
by Klaire Labs
What is this page for?
First and foremost: checking SAMe 200 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SAMe 200 is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for depression, osteoarthritis joint pain, liver conditions.Based on those ingredients, 189 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are S-Adenosyl L-Methionine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against SAMe 200 by Klaire Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with SAMe 200 by Klaire Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of SAMe 200 by Klaire Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: S-Adenosyl L-Methionine Tosylate Disulfate, a compound your body makes naturally and uses in hundreds of chemical reactions — particularly ones involved in mood, joint health, and liver function. The tablet also contains inactive ingredients (microcrystalline cellulose, magnesium silicate, food glaze, magnesium stearate, stearic acid, magnesium hydroxide, glycerol, silicon dioxide, arginine, sodium alginate, and calcium oxide) that help hold the tablet together and make it easier to swallow.
Does it work?
Strong evidence
SAMe is likely effective for osteoarthritis — the research supports its use for joint pain and stiffness. It's possibly effective for depression and for cholestasis (a liver condition involving bile flow).
For Alzheimer disease and ADHD, the evidence is insufficient to say whether it works. If you're considering it for one of these conditions, talk with your doctor about whether the research supports trying it for your particular situation.
How safe is it?
Well-documented data
SAMe is generally well tolerated at typical doses, though side effects are more common at higher doses. The most frequent ones are stomach-related: nausea, diarrhea, constipation, stomach upset, and loss of appetite.
Some people report headache, dizziness, insomnia, or nervousness. There's also a caution: SAMe may trigger mania in people with bipolar disorder, so it shouldn't be used without close monitoring if you have that condition.
Safety data overall is limited, so use it only under guidance from your healthcare provider. For pregnancy, the available data suggests it's possibly safe, but there isn't enough information about breastfeeding — talk with your doctor or pharmacist to weigh the risks and benefits for your situation.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take serotonergic drugs — antidepressants, certain pain relievers like tramadol, or migraine medications — because SAMe may raise the risk of serotonin syndrome. Also check if you take levodopa for Parkinson disease, since SAMe might reduce how well it works.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
SAMe may be worth considering if you have osteoarthritis or depression and want to explore natural options — the evidence supports its use for those. But it's not for everyone: if you take serotonergic medications (like SSRIs), levodopa, or have bipolar disorder, you'll need to clear it with your doctor first.
Check your exact medications before starting, and use it only under professional guidance.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SAMe 200, straight from the product label.
| Brand | Klaire Labs |
|---|---|
| Barcode (UPC) | 828054010215 |
| Net contents | 60 Enteric Extended Release Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Feb 21, 2023 |
| DSLD ID | 281398 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SAMe 200 by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| S-Adenosyl L-Methionine | 200 mg | -- |
| S-Adenosyl L-Methionine Tosylate Disulfate | 400 mg | -- |
Other ingredients: Microcrystalline Cellulose, Magnesium Silicate, Food Glaze, Magnesium Stearate, Stearic Acid, Magnesium Hydroxide, Glycerol, Silicon Dioxide, Arginine, Sodium Alginate, Calcium Oxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
200 mg Elemental SAMe s-adenosyl l-methionine
Each tablet contains a full 200 mg of elemental SAMe from 400 mg SAMe tosylate disulfate.
SAMe (S-adenosylmethionine) is a derivative of the essential amino acid methionine and is formed by combining ATP with L-methionine. SAMe is a chiral molecule and consists of two stereoisomers: (S,S) and (R,S). This SAMe has a high level (65%) of the (S,S) isomer, the biologically active form.
FDA Statement of Identity
Dietary Supplement
Formulation
60 enteric extended release tablets in foil blister packets
This SAMe 200 is a pharmaceutical grade, stabilized SAMe manufactured under low temperature and low humidity conditions.
These enteric extended release tablets offer improved delivery and comply with or exceed the standards established by the United States Pharmacopeia (USP). Slow-release coating technology optimizes stability in the stomach and enhances direct release and absorption in the small intestine.
SAMe has a long history of clinical use with proven benefits for brain metabolism, joint function, and liver detoxification. Some of the reported beneficial actions of SAMe include: Joint and connective tissue strength SAMe supports production of healthy connective tissue and joint structures by contributing its sulfur component for transulfuration processes that help form glucosamine and chondroitin sulfates, critical components of connective tissues. Brain metabolism SAMe serves as a major source of methyl groups used by the brain in the synthesis of neurotransmitters such as serotonin, L-dopa, dopamine, and related hormones involved in mood regulation. Liver function Metabolism of SAMe supports synthesis of glutathione and glutathione-dependant enzymes (glutathione peroxidase and glutathione-S-transferase), which are important antioxidants used in liver detoxification processes.
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans.
SAMe 200 is provided in individual foil blister packets to maximize product stability.
Produced in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.
Brand IP Statement(s)
SFI
Precautions
Caution: If under 18 years of age, pregnant/nursing, have a medical condition or taking a prescription medication - including those related to mood modulation - consult your physician before use.
Do not exceed 1,600 mg SAMe per day (8 tablets). Do not take at night since product may cause anxiety, restlessness and insomnia.
Caution: If under 18 years of age, pregnant/nursing, have a medical condition or taking a prescription medication - including those related to mood modulation - consult your physician before use. Keep out of reach of children.
Do not use if outer seal of blister pack is broken.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Suggested use: Adults: 1 tablet, 2 to 6 times daily or as directed by a healthcare professional. Do not chew or crush tablets.
Storage
Store in a cool, dry place (59 degrees F-85 degrees F) away from direct light.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SAMe 200 by Klaire Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SAMe 200 by Klaire Labs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
S-Adenosyl L-Methionine
Interacts with189 drugs
SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...
S-Adenosyl L-Methionine monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Magnesium Silicate, Food Glaze, Magnesium Stearate, Stearic Acid, Magnesium Hydroxide, Glycerol, Silicon Dioxide, Arginine, Sodium Alginate, Calcium Oxide. These complete the product’s ingredient list but are not active constituents.
SAMe 200 by Klaire Labs Drug Interactions
HelloPharmacist Interaction Report
Klaire Labs SAMe 200 contains S-Adenosyl L-Methionine Tosylate Disulfate, which interacts with serotonergic drugs and levodopa.
The most serious concern is with serotonergic medications (antidepressants, certain pain relievers, migraine drugs) — combining them with SAMe raises the risk of serotonin syndrome, a potentially dangerous buildup of serotonin in your system that can cause confusion, rapid heart rate, high blood pressure, and muscle stiffness.
Read the full breakdown — every affected drug type, severity by severity
SAMe also affects how your body handles levodopa, a medication for Parkinson disease — it may reduce how well levodopa works. Altogether, these interactions span 189 individual medications.
If you take any serotonergic drug or levodopa, check your exact medications with the tool on this page before starting SAMe. Your doctor or pharmacist can tell you whether it's safe to combine them or if timing adjustments might help.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against SAMe 200?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in SAMe 200 interact with 189 drugs. Click any drug to see the details.
1 of the 1 ingredient in SAMe 200 interact with drugs. Each result below shows which ingredient is responsible. S-Adenosyl L-Methionine
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Meperidine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Almotriptan interactionAlosetronLotronex
How Alosetron interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Alosetron interactionAmitriptylineElavil
How Amitriptyline interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Amitriptyline, Perphenazine interactionAmoxapineAsendin
How Amoxapine interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Amoxapine interactionAmphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine SulfateAdderall, Adderall XR
How Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with SAMe 200 — through 1 ingredient. Tap an ingredient for the detail:
S-adenosyl L-methionine Tosylate DisulfateSerotonergic Drugs Moderate
Interaction Summary
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
Read the full S-adenosyl L-methionine Tosylate Disulfate + Aripiprazole interactionEach ingredient & the kinds of drugs it affects
For each ingredient in SAMe 200 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
S-Adenosyl L-Methionine
Levodopa
SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.
Serotonergic Drugs
Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.
Brand information
Manufacturer and brand details for SAMe 200, from the product label.
Klaire Labs
See all Klaire Labs products- Name
- SFI USA
- City
- Reno
- State
- NV
- ZipCode
- 89521
- Web Address
- Klaire.com
SAMe 200 by Klaire Labs: Common Questions
Does SAMe 200 by Klaire Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is SAMe, and what does it do in the body?
Does SAMe actually work for arthritis or depression?
What side effects might I get?
Is it safe to take SAMe while pregnant or breastfeeding?
Can I take this with my antidepressant?
How much do I take, and how long does it take to work?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if SAMe 200 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind SAMe 200’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
SAMe 200's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Same 31 references
- Perna AF, Castaldo P, Ingrosso D, et al. Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin. J Nephrol 1999;12:230-40.
- Mato JM, Camara J, Fernandez de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999;30:1081-9. PubMed
- Iruela LM, Minguez L, Merino J, Monedero G. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 1993;150:522. PubMed
- Bradley JD, Flusser D, Katz BP, et al. A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21:905-11.
- Berlanga C, Ortega-Soto HA, Ontiveros M, Senties H. Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine. Psychiatry Res 1992;44:257-62. PubMed
- Kagan BL, Sultzer DL, Rosenlicht N, Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 1990;147:591-5. PubMed
- Rosenbaum JF, Fava M, Falk WE, et al. The antidepressant potential of oral S-adenosyl-l-methionine. Acta Psychiatr Scand 1990;81:432-6. PubMed
- Domljan Z, Vrhovac B, Durrigl T, Pucar I. A double-blind trial of ademetionine vs naproxen in activated gonarthrosis. Int J Clin Pharmacol Ther Toxicol 1989;27:329-33.
- Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83:89-94. PubMed
- Lipinski JF, Cohen BM, Frankenburg F, et al. Open trial of S-adenosylmethionine for treatment of depression. Am J Psychiatry 1984;141:448-50.
- Almasio P, Bortolini M, Pagliaro L, Coltorti M. Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. Drugs 1990;40:111-23. PubMed
- Friedel HA, Goa KL, Benfield P. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 1989;38:389-416. PubMed
- Bottiglieri T, Hyland K, Reynolds EH. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52. PubMed
- Frezza M, Centini G, Cammareri G, et al. S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. Hepatogastroenterology 1990;37:122-5.
- Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
- Charlton CG, Crowell B Jr. Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423-31..
- Goren JL, Stoll AL, Damico KE, et al. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 2004;24:1501-7. PubMed
- Arnold O, Saletu B, Anderer P, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur Neuropsychopharmacol 2005; PubMed
- Nelson JC. S-adenosyl methionine (SAMe) augmentation in major depressive disorder. (Editorial). Am J Psychiatry 2010;167:889-91.
- Kim J, Lee EY, Koh EM, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther 2009; PubMed
- Manzillo G, Piccinino F, Surrenti C, et al. Multicentre double-blind placebo-controlled study of intravenous and oral S-adenosyl-L-methionine (SAMe) in cholestatic patients with liver disease. Drug Invest 1992;4 (Suppl 4):90-100. DOI
- Carrieri PB, Indaco A, Gentile S, et al. S-adenosylmethionine treatment of depressioin in patients with Parkinson's disease: a double-blind, crossover study versus placebo. Curr Ther Res 1990;48(1):154-60.
- Pancheri P, Scapicchio P, Delle Chiaie R. A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder. Int J Neuro PubMed
- Medici V., Virata M. C., Peerson J. M., Stabler S. P., French S. W., Gregory J. F. III, Albanese A., Bowlus C. L., Devaraj S., Panacek E. A., Richards J. R., Halsted C. H. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, ra
- Chitiva, H., Audivert, F., and Alvarez, C. Suicide attempt by self-burning associated with ingestion of S-adenosylmethionine: a review of the literature and case report. J.Nerv.Ment.Dis. 2012;200(1):99-101. PubMed
- Carney, M. W., Edeh, J., Bottiglieri, T., Reynolds, E. M., and Toone, B. K. Affective illness and S-adenosyl methionine: a preliminary report. Clin Neuropharmacol. 1986;9(4):379-385. PubMed
- Miccoli, L., Porro, V., and Bertolino, A. Comparison between the antidepressant activity and of S- adenosylmethionine (SAMe) and that of some tricyclic drugs. Acta Neurol (Napoli) 1978;33 (3):243-255.
- Bacci, Ballerini F., Lopez, Anguera A., Alcaraz, P., and Hernandez, Reyes N. [SAMe in the management of postconcussional syndrome]. Medicina Clinica (Barc.) 1983;80(4):161-164.
- Muscettola G, Galzenati M, Balbi A. SAMe versus placebo: a double blind comparison in major depressive disorders. Advances in Biochemical Psychopharmacology 1982;32:151-6.
- Capretto C, Cremona C, and Canaparo L. A double-blind controlled study of S-adenosylmethionine (SAMe) v. ibuprofen in gonarthrosis, coxarthrosis and spondylarthrosis. Clin Trials J 1985;22(1):15-24.
- Ancarani E, Biondi B, Bolletta A, et al. Major depression complicating hemodialysis in patients with chronic renal failure: a multicenter, double-blind, controlled clinical trial of S-adenosyl-L-methionine versus placebo. Curr Ther Res 1993;54(6):680-6. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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