Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Sheep Sorrel Ingredients & Drug Interactions

by Pure Herbs

Sheep Sorrel label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sheep Sorrel against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sheep Sorrel is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for sinus and respiratory congestion, digestive upset, fever.Based on those ingredients, 169 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sheep Sorrel aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sheep Sorrel by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Sheep Sorrel by Pure Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Sheep Sorrel by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Herbs Sheep Sorrel is a single-ingredient liquid supplement. It contains sheep sorrel aerial parts extract — that's the above-ground portion of the plant (stems, leaves, flowers) concentrated into liquid form.

This is the only active ingredient in the product.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sorrel's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Beneficial for overall good health.
  • We looked for evidence on: Bronchitis, Rhinosinusitis, Respiratory health, Immune support, Antioxidant support.
  • The closest evidence on file: Sorrel is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: Sorrel is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis.

The evidence for sheep sorrel isn't established in the data we hold. Sorrel has been studied for bronchitis, breast cancer, and rhinosinusitis (sinus inflammation), but none of those uses have sufficient reliable evidence to rate whether it actually works.

If you're thinking about trying it for a specific condition, it's worth asking your doctor or pharmacist what the science actually supports.

The evidence, ingredient by ingredient Sorrel

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sheep sorrel is generally well tolerated when eaten as a food in normal amounts. However, it does contain oxalates — compounds that can build up in your system at high or concentrated doses and may damage your kidneys.

A case of serious kidney inflammation was reported in a child who consumed wild sorrel, so medicinal or concentrated supplements are best avoided unless you've talked with a pharmacist or doctor. There's also a small risk of allergic reactions.

Sorrel pollen can trigger allergic rhinitis or asthma in people sensitive to weed pollen, and up to 19% of people allergic to weed pollen may react to sorrel. When combined with other herbs, sorrel has caused nausea and an unpleasant aftertaste in some people.

Safety data for medicinal use while breastfeeding is limited, so it's best to avoid concentrated supplements if you're nursing.

Side effects, ingredient by ingredient Sorrel

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sorrel.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 169 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin or clopidogrel) — sorrel may increase bleeding risk. Also flag it if you're on fexofenadine (Allegra) or any other medication that relies on OATP transporters for absorption, since sorrel may reduce how well those drugs work.

Because 169 medications can be affected, running your prescriptions through the checker below is important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Sheep sorrel may be worth considering if you're exploring herbal options, but it's not without concerns — especially if you take blood thinners, allergy medications, or other drugs that depend on specific absorption pathways. If you're on any prescription medication, check it against your exact drugs using the tool on this page before you start.

A conversation with your pharmacist can help you weigh whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sheep Sorrel, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278874
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sheep Sorrel by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Sheep Sorrel aerial parts extract1841 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for overall good health.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sheep Sorrel by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sheep Sorrel label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sheep Sorrel by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Sheep Sorrel aerial parts extract

Interacts with
169 drugs
1841 mg per serving

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for an...

Sheep Sorrel aerial parts extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sheep Sorrel by Pure Herbs Drug Interactions

Want to check YOUR meds against Sheep Sorrel?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
169Drugs
169 Moderate

Ingredients driving the most interactions

Sheep Sorrel aerial parts extract 169

Individual Drug Interactions

The ingredients in Sheep Sorrel interact with 169 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sheep Sorrel interact with drugs. Each result below shows which ingredient is responsible. Sheep Sorrel aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sheep Sorrel with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sheep Sorrel aerial parts extract3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Sheep Sorrel aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sheep Sorrel, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Sheep Sorrel by Pure Herbs: Common Questions

Does Sheep Sorrel by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Sheep Sorrel has a known interaction with 169 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sheep Sorrel contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is sheep sorrel safe to use while breastfeeding?
Safety data for medicinal or concentrated doses while breastfeeding is limited. Food amounts are likely fine, but the data we hold advises against taking concentrated supplements while nursing. Talk with your doctor or pharmacist about whether it's right for you.
Can sheep sorrel hurt my kidneys?
Sheep sorrel contains oxalates, which can accumulate in your system at high or concentrated doses and potentially cause kidney damage. A serious case of kidney inflammation was reported in a child who consumed wild sorrel. Large or concentrated doses are best avoided unless you've discussed it with a healthcare provider.
Does sheep sorrel actually work for bronchitis or other conditions?
The evidence isn't established in the data we hold. Sorrel has been studied for bronchitis, breast cancer, and sinus inflammation, but there isn't sufficient reliable evidence yet to say whether it works for any of those uses.
Can sheep sorrel trigger allergies?
Yes — sorrel pollen can trigger allergic rhinitis or asthma in people sensitive to weed pollen. Up to 19% of people allergic to weed pollen may also react to sorrel. If you have a known weed pollen allergy, mention this product to your pharmacist.
Will this liquid sorrel upset my stomach?
When sorrel was combined with other herbs, nausea and an unpleasant aftertaste have been reported. There isn't much data on side effects from sorrel alone, so if you have a sensitive stomach, start slowly and watch how you feel.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sheep Sorrel is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sheep Sorrel label
Go deeper

The Full Monographs Behind Sheep Sorrel’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph →
Sources

Sources & How We Checked

Sheep Sorrel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sorrel 8 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

See these in context on the Sorrel monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team