Immune Defense Mixed Berry Ingredients & Drug Interactions
by Country Farms
What is this page for?
First and foremost: checking Immune Defense Mixed Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Immune Defense Mixed Berry is a dietary supplement by Country Farms with 6 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,337 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Magnesium, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Immune Defense Mixed Berry by Country Farms
Ask about any prescription or over-the-counter medication and we check it for interactions with Immune Defense Mixed Berry by Country Farms — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Immune Defense Mixed Berry by Country Farms
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Immune Defense Mixed Berry contains 32 ingredients, of which the active ones are the minerals zinc, magnesium, and potassium; the probiotic Lactobacillus sporogenes (also called Bacillus coagulans); fiber from apple and beet; and a herbal blend featuring turmeric, ginger, cranberry, spinach, kale, parsley, elderberry, acai, aronia, cordyceps, lion's mane mushroom, shiitake mushroom, blueberry, maqui, and a prebiotic and probiotic blend. We could not check watermelon or brussel sprouts because we hold no data for them.
The inactive ingredients are fillers and flavor components including glucose, guar gum, citric acid, natural flavors, silica, stevia, and monk fruit extract.
Does it work?
Moderate evidence
Evidence on this product's ingredients is mixed. Zinc is effective for zinc deficiency and likely effective for Wilson disease, though it's only possibly effective for acne and several other conditions.
Magnesium is effective for dyspepsia and constipation. Most of the herbal ingredients—turmeric, ginger, cranberry, and blueberry—show only possibly effective ratings for their listed uses (ginger for pregnancy-induced nausea, turmeric for depression and hyperlipidemia, for example), or insufficient evidence.
Lactobacillus sporogenes is possibly effective for constipation and IBS, but insufficient evidence exists for antibiotic-associated diarrhea. The evidence we hold doesn't establish effectiveness for most of the other ingredients or for an overall immune-support claim.
How safe is it?
Well-documented data
Zinc is generally well tolerated in recommended amounts but can cause dose-related nausea, diarrhea, metallic taste, and abdominal cramps; high doses above 40 mg daily may raise the risk of copper deficiency. Magnesium is generally well tolerated and typically causes mild gastrointestinal effects like diarrhea or nausea at higher doses.
Potassium from supplements can be dangerous in people with kidney disease and requires careful monitoring. The probiotic is generally well tolerated but carries a theoretical risk of infection in severely immunocompromised patients with central lines.
Turmeric is generally well tolerated as a food but concentrated supplements have been linked to rare liver damage. Ginger is well tolerated at typical doses but higher doses (above 5 grams daily) increase side effects.
Most other herbal ingredients are generally well tolerated when used in food amounts, though concentrated supplement forms have limited safety data. Pregnancy and breastfeeding safety varies by ingredient; several ingredients (parsley, cordyceps, lion's mane) lack adequate safety information for pregnancy or lactation.
Meds to double-check
Major interaction found
Before taking this product, check with your doctor or pharmacist if you take any blood pressure medications (especially ACE inhibitors, ARBs, calcium channel blockers, or diuretics), diabetes medications, antibiotics (quinolones, tetracyclines, cephalexin), levodopa/carbidopa for Parkinson's disease, blood thinners or antiplatelet drugs (warfarin, aspirin), anticoagulants, statins, HIV medications, or immunosuppressant drugs. The interactions documented in our data range from Major down to Minor severity, so individual review of your medication list is important.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This is a multi-ingredient supplement with active minerals, probiotics, and herbs aimed at immune support. Because it contains zinc, magnesium, potassium, apple fiber, and multiple herbal ingredients that interact with many common medications—especially blood pressure drugs, diabetes medications, anticoagulants, and antibiotics—you'll want to review your specific medications before taking it.
The evidence for most ingredients on immune function itself is limited or not yet established. Talk with your doctor or pharmacist about whether this product is right for you and whether it's safe to combine with your current treatments.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 31 of 33 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Immune Defense Mixed Berry, straight from the product label.
| Brand | Country Farms |
|---|---|
| Barcode (UPC) | 035046112004 |
| Net contents | 11.3 Ounce(s); 320 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2024 |
| DSLD ID | 307983 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Immune Defense Mixed Berry by Country Farms, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrates | 3 Gram(s) | 1% |
| Added Sugars | 1 Gram(s) | 2% |
| Total Sugars | 1 Gram(s) | -- |
| Dietary Fiber | 2 Gram(s) | 7% |
| Zinc | 20 mg | 182% |
| Magnesium | 21 mg | 5% |
| Potassium | 235 mg | 5% |
| Lactobacillus sporogenes | 0 NP | -- |
| Apple Fiber | 0 NP | -- |
| Herbal Support Blend | 0 NP | -- |
| Turmeric | 0 NP | -- |
| Ginger | 0 NP | -- |
| Cranberry | 0 NP | -- |
| Spinach | 0 NP | -- |
| Kale | 0 NP | -- |
| Parsley | 0 NP | -- |
| Elderberry | 0 NP | -- |
| Acai | 0 NP | -- |
| Beet Fiber | 0 NP | -- |
| Beet | 0 NP | -- |
| Aronia | 0 NP | -- |
| Cordyceps | 0 NP | -- |
| Lion's Mane Mushroom | 0 NP | -- |
| Shiitake Mushroom | 0 NP | -- |
| Blueberry | 0 NP | -- |
| Prebiotic and Probiotic Blend | 0 NP | -- |
| Watermelon | 0 NP | -- |
| Brussel Sprouts | 0 NP | -- |
| Maqui | 0 NP | -- |
| Celery | 0 NP | -- |
| Reishi Mushroom | 0 NP | -- |
| Broccoli Sprout | 0 NP | -- |
| Chicory Root Inulin | 0 NP | -- |
| Immunity Superfoods | 2600 mg | -- |
| Hydration Boosters | 0 NP | -- |
| Multi-Mushrooms | 0 NP | -- |
| Immune Berries | 0 NP | -- |
| Alkalizing Greens | 0 NP | -- |
| Echinacea purpurea | 0 NP | -- |
| Vitamin C | 1000 mg | 1111% |
| Holy Basil | 0 NP | -- |
| Coconut Water | 0 NP | -- |
| Amla | 0 NP | -- |
Other ingredients: D-Glucose, Guar Gum, Citric Acid, Natural Flavors, Silica, Stevia, Natural, Monk Fruit Extract, Natural
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Immune system support Complete immune support Supports hydration Promotes gut immunity
Non-GMO Gluten free
Vegan
Made in the U.S.A. from globally sourced ingredients.
Formula
Alkalizing greens
Green & red superfoods Immune Defense with Vitamin C Elderberry & Zinc Mushroom blend Echinacea, turmeric & probiotics
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Vegan
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Mix 1 scoop (8g) of Immune Defense with 10-12 fl. oz. of spring or filtered water. Consume once daily on an empty stomach.
Precautions
Keep out of reach of children.
Do not purchase if seal is broken.
Contains: Coconut.
Storage
Store in a cool, dry place. Protect from heat, light and moisture.
General Statements
Sold by weight, not volume. Settling may have Facebook Instagram @countryfarms For more information, visit: CountryFarms.com
Brand IP Statement(s)
Country Farms Farm fresh since 1975
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Immune Defense Mixed Berry by Country Farms label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Immune Defense Mixed Berry by Country Farms
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size8 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dietary Fiber
Interacts with2,025 drugs
Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...
Dietary Fiber monograph & interactionsZinc
Interacts with67 drugs
Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...
Zinc monograph & interactionsMagnesium
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Magnesium monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsImmunity Superfoods
- › Prebiotic and Probiotic Blend
Vitamin C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
Vitamin C monograph & interactionsOther (inactive) ingredients: D-Glucose, Guar Gum, Citric Acid, Natural Flavors, Silica, Stevia, Natural, Monk Fruit Extract, Natural. These complete the product’s ingredient list but are not active constituents.
Immune Defense Mixed Berry by Country Farms Drug Interactions
HelloPharmacist Interaction Report
Immune Defense Mixed Berry by Country Farms contains several ingredients with documented interactions with medications.
Through its zinc, magnesium, potassium, and apple fiber content, this product interacts with a wide range of drug types. The most serious interaction is magnesium's Major-severity effect on levodopa/carbidopa, which can reduce levodopa levels by 35% and carbidopa levels by 81%, potentially worsening Parkinson's symptoms.
Read the full breakdown — every affected drug type, severity by severity
Zinc moderately interacts with quinolone antibiotics, tetracyclines, cephalexin, penicillamine, and several HIV medications by reducing their absorption or effectiveness. Magnesium moderately interacts with calcium channel blockers, muscle relaxants, bisphosphonates, and other drug types.
Potassium moderately increases the risk of dangerously high blood potassium levels when combined with ACE inhibitors, ARBs, or potassium-sparing diuretics. Apple fiber's Major interaction affects OATP substrates (including fexofenadine and atenolol), reducing their absorption by up to 78%.
Additional Moderate interactions span turmeric (chemotherapy drugs, tacrolimus, methotrexate, tramadol), ginger (anticoagulants, antiplatelet drugs, antidiabetes medications), cranberry (statin and CYP3A4 drugs), spinach (warfarin, antidiabetes drugs), parsley (anticoagulants, antidiabetes drugs, diuretics), elderberry (immunosuppressants), and the mushroom ingredients (anticoagulants, antidiabetes drugs, immunosuppressants). Minor interactions involve blueberry, aronia, and beet with various drug types.
Altogether, these interactions span 1,665 individual medications. Check your exact medications with the search tool on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Immune Defense Mixed Berry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Immune Defense Mixed Berry interact with 2,337 drugs. Click any drug to see the details.
5 of the 6 ingredients in Immune Defense Mixed Berry interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Magnesium Vitamin C Zinc Potassium
AtorvastatinAtorvaliq
How Atorvastatin interacts with Immune Defense Mixed Berry — through 8 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Atorvastatin interactionTurmericCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Turmeric + Atorvastatin interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Atorvastatin interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Atorvastatin interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Atorvastatin interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Atorvastatin interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Atorvastatin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Immune Defense Mixed Berry — through 8 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Atorvastatin Calcium interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Atorvastatin Calcium interactionCranberryAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
Read the full Cranberry + Atorvastatin Calcium interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Atorvastatin Calcium interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Atorvastatin Calcium interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp), Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Atorvastatin Calcium interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Atorvastatin Calcium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Atorvastatin Calcium interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Immune Defense Mixed Berry — through 2 ingredients. Tap an ingredient for the detail:
MagnesiumLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium + Benserazide, Levodopa interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Benserazide, Levodopa interactionBosentanTracleer
How Bosentan interacts with Immune Defense Mixed Berry — through 10 ingredients. Tap an ingredient for the detail:
Apple FiberAntihypertensive Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fiber + Bosentan interactionTurmericHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Bosentan interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Bosentan interactionGingerCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, ginger might increase the levels of CYP2C9 substrates.
Read the full Ginger + Bosentan interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Bosentan interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Bosentan interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Bosentan interactionCeleryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Read the full Celery + Bosentan interactionReishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Bosentan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Bosentan interactionBrincidofovirTembexa
How Brincidofovir interacts with Immune Defense Mixed Berry — through 3 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Brincidofovir interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Brincidofovir interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Brincidofovir interactionCarbidopaLodosyn
How Carbidopa interacts with Immune Defense Mixed Berry — through 2 ingredients. Tap an ingredient for the detail:
MagnesiumLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium + Carbidopa interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbidopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Immune Defense Mixed Berry — through 2 ingredients. Tap an ingredient for the detail:
MagnesiumLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium + Carbidopa, Levodopa interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Immune Defense Mixed Berry — through 2 ingredients. Tap an ingredient for the detail:
MagnesiumLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium + Carbidopa, Levodopa, Entacapone interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Carbidopa, Levodopa, Entacapone interactionCeliprololCelicard
How Celiprolol interacts with Immune Defense Mixed Berry — through 7 ingredients. Tap an ingredient for the detail:
Apple FiberAntihypertensive Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Fiber + Celiprolol interactionGingerP-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger + Celiprolol interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp), P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Celiprolol interactionCeleryAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Read the full Celery + Celiprolol interactionReishi MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Celiprolol interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Celiprolol interactionBeetAntihypertensive Drugs Minor
Interaction Summary
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Beet + Celiprolol interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with Immune Defense Mixed Berry — through 3 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Cerivastatin Sodium interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp), Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Cerivastatin Sodium interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Cerivastatin Sodium interactionCinoxacinCinobac
How Cinoxacin interacts with Immune Defense Mixed Berry — through 7 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Cinoxacin interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp), Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Cinoxacin interactionMagnesiumQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magnesium + Cinoxacin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Cinoxacin interactionZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Cinoxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Cinoxacin interactionCeleryPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Immune Defense Mixed Berry — through 7 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Ciprofloxacin interactionTurmericHepatotoxic Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Ciprofloxacin interactionZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Ciprofloxacin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Ciprofloxacin interactionMagnesiumQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magnesium + Ciprofloxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ciprofloxacin interactionCeleryPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery + Ciprofloxacin interactionCiprofloxacin, HydrocortisoneCipro HC Otic
How Ciprofloxacin, Hydrocortisone interacts with Immune Defense Mixed Berry — through 2 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Ciprofloxacin, Hydrocortisone interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Ciprofloxacin, Hydrocortisone interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Immune Defense Mixed Berry — through 6 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Clinafloxacin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Clinafloxacin interactionZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Clinafloxacin interactionMagnesiumQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magnesium + Clinafloxacin interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Clinafloxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Clinafloxacin interactionEnoxacinPenetrex
How Enoxacin interacts with Immune Defense Mixed Berry — through 7 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Enoxacin interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Enoxacin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Enoxacin interactionMagnesiumQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magnesium + Enoxacin interactionZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Enoxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Enoxacin interactionCeleryPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery + Enoxacin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Immune Defense Mixed Berry — through 8 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Etoposide interactionEchinacea PurpureaEtoposide (vepesid), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may increase levels of etoposide.
Read the full Echinacea Purpurea + Etoposide interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Etoposide interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Etoposide interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Etoposide interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Etoposide interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp), P-glycoprotein Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Etoposide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Etoposide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with Immune Defense Mixed Berry — through 8 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Ezetimibe, Atorvastatin interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Ezetimibe, Atorvastatin interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp), Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Ezetimibe, Atorvastatin interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Ezetimibe, Atorvastatin interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Ezetimibe, Atorvastatin interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Ezetimibe, Atorvastatin interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Ezetimibe, Atorvastatin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Ezetimibe, Atorvastatin interactionFexofenadineAllegra
How Fexofenadine interacts with Immune Defense Mixed Berry — through 8 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Fexofenadine interactionTurmericCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Turmeric + Fexofenadine interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Fexofenadine interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Fexofenadine interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Fexofenadine interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Fexofenadine interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Fexofenadine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with Immune Defense Mixed Berry — through 8 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Fexofenadine, Pseudoephedrine interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Fexofenadine, Pseudoephedrine interactionTurmericP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Moderate
Interaction Summary
Theoretically, turmeric might increase the absorption of P-glycoprotein substrates.
Read the full Turmeric + Fexofenadine, Pseudoephedrine interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Fexofenadine, Pseudoephedrine interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Fexofenadine, Pseudoephedrine interactionGingerP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
Read the full Ginger + Fexofenadine, Pseudoephedrine interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Fexofenadine, Pseudoephedrine interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Fexofenadine, Pseudoephedrine interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with Immune Defense Mixed Berry — through 5 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Fluvastatin interactionTurmericHepatotoxic Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Fluvastatin interactionCranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Fluvastatin interactionGingerCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP2C9 substrates.
Read the full Ginger + Fluvastatin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Fluvastatin interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with Immune Defense Mixed Berry — through 7 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Gatifloxacin interactionTurmericHepatotoxic Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Gatifloxacin interactionZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Gatifloxacin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Gatifloxacin interactionMagnesiumQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magnesium + Gatifloxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Gatifloxacin interactionCeleryPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with Immune Defense Mixed Berry — through 6 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Gemifloxacin interactionZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Gemifloxacin interactionMagnesiumQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magnesium + Gemifloxacin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Gemifloxacin interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Gemifloxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Gemifloxacin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Immune Defense Mixed Berry — through 19 ingredients. Tap an ingredient for the detail:
Apple FiberAntidiabetes Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Fiber + Glyburide interactionAmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Amla + Glyburide interactionTurmericGlyburide (diabeta, Others), Organic Anion-transporting Polypeptide Substrates (oatp) +2 Moderate
Interaction Summary
Theoretically, taking turmeric and glyburide in combination might increase the risk of hypoglycemia.
Read the full Turmeric + Glyburide interactionGingerAntidiabetes Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ginger + Glyburide interactionReishi MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Mushroom + Glyburide interactionParsleyAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Parsley + Glyburide interactionHoly BasilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Holy Basil + Glyburide interactionAcaiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai + Glyburide interactionMagnesiumSulfonylureas Moderate
Interaction Summary
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Read the full Magnesium + Glyburide interactionSpinachAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach + Glyburide interactionLion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Glyburide interactionAroniaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aronia + Glyburide interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glyburide interactionCranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Glyburide interactionCeleryPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery + Glyburide interactionBlueberryAntidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry + Glyburide interactionChicory Root InulinAntidiabetes Drugs Minor
Interaction Summary
Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Read the full Chicory Root Inulin + Glyburide interactionMaquiAntidiabetes Drugs Minor
Interaction Summary
Theoretically, maqui fruit extract may increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Maqui + Glyburide interactionCoconut WaterAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coconut Water + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Immune Defense Mixed Berry — through 19 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp), Antidiabetes Drugs Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Glyburide, Metformin interactionAroniaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aronia + Glyburide, Metformin interactionLion's Mane MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane Mushroom + Glyburide, Metformin interactionParsleyAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Parsley + Glyburide, Metformin interactionReishi MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi Mushroom + Glyburide, Metformin interactionGingerAntidiabetes Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Ginger + Glyburide, Metformin interactionDietary FiberOral Drugs, Metformin (glucophage) Moderate
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Glyburide, Metformin interactionTurmericAntidiabetes Drugs, Glyburide (diabeta, Others) +2 Moderate
Interaction Summary
Theoretically, taking turmeric with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Turmeric + Glyburide, Metformin interactionAmlaAntidiabetes Drugs Moderate
Interaction Summary
Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Amla + Glyburide, Metformin interactionSpinachAntidiabetes Drugs Moderate
Interaction Summary
There are claims that spinach leaves have hypoglycemic effects.
Read the full Spinach + Glyburide, Metformin interactionMagnesiumSulfonylureas Moderate
Interaction Summary
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Read the full Magnesium + Glyburide, Metformin interactionHoly BasilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Holy Basil + Glyburide, Metformin interactionAcaiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.
Read the full Acai + Glyburide, Metformin interactionCoconut WaterAntidiabetes Drugs Minor
Interaction Summary
Theoretically, taking coconut with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Coconut Water + Glyburide, Metformin interactionCeleryPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery + Glyburide, Metformin interactionCranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Glyburide, Metformin interactionMaquiAntidiabetes Drugs Minor
Interaction Summary
Theoretically, maqui fruit extract may increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Maqui + Glyburide, Metformin interactionBlueberryAntidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry + Glyburide, Metformin interactionChicory Root InulinAntidiabetes Drugs Minor
Interaction Summary
Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Read the full Chicory Root Inulin + Glyburide, Metformin interactionGrepafloxacinRaxar
How Grepafloxacin interacts with Immune Defense Mixed Berry — through 12 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Grepafloxacin interactionTurmericOrganic Anion-transporting Polypeptide Substrates (oatp), Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, turmeric might increase blood levels of OATP4C1 substrates.
Read the full Turmeric + Grepafloxacin interactionParsleyCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley + Grepafloxacin interactionCeleryCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery + Grepafloxacin interactionZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Grepafloxacin interactionBroccoli SproutCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Read the full Broccoli Sprout + Grepafloxacin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Grepafloxacin interactionMagnesiumQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magnesium + Grepafloxacin interactionEchinacea PurpureaCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea + Grepafloxacin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Grepafloxacin interactionGingerCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, ginger might increase the levels of CYP1A2 substrates.
Read the full Ginger + Grepafloxacin interactionBeetCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beet + Grepafloxacin interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with Immune Defense Mixed Berry — through 8 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Irinotecan interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Irinotecan interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Irinotecan interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Irinotecan interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Irinotecan interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Irinotecan interactionTurmericCytochrome P450 3a4 (cyp3a4) Substrates, Topoisomerase I Inhibitors +1 Moderate
Interaction Summary
Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full Turmeric + Irinotecan interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with Immune Defense Mixed Berry — through 7 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Irinotecan Hydrochloride interactionTurmericTopoisomerase I Inhibitors, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Moderate
Interaction Summary
Turmeric has antioxidant effects.
Read the full Turmeric + Irinotecan Hydrochloride interactionBeetCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beet + Irinotecan Hydrochloride interactionCranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Cranberry + Irinotecan Hydrochloride interactionAroniaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.
Read the full Aronia + Irinotecan Hydrochloride interactionGingerCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Ginger might increase or decrease the levels of CYP3A4 substrates.
Read the full Ginger + Irinotecan Hydrochloride interactionEchinacea PurpureaCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea + Irinotecan Hydrochloride interactionIsoniazid, Pyrazinamide, RifampinRifater
How Isoniazid, Pyrazinamide, Rifampin interacts with Immune Defense Mixed Berry — through 4 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Isoniazid, Pyrazinamide, Rifampin interactionTurmericHepatotoxic Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Isoniazid, Pyrazinamide, Rifampin interactionCeleryPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery + Isoniazid, Pyrazinamide, Rifampin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Isoniazid, Pyrazinamide, Rifampin interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with Immune Defense Mixed Berry — through 4 ingredients. Tap an ingredient for the detail:
Apple FiberOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Fiber + Isoniazid, Rifampin interactionTurmericHepatotoxic Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Moderate
Interaction Summary
Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Turmeric + Isoniazid, Rifampin interactionLactobacillus SporogenesAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.
Read the full Lactobacillus Sporogenes + Isoniazid, Rifampin interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Isoniazid, Rifampin interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Immune Defense Mixed Berry — through 2 ingredients. Tap an ingredient for the detail:
MagnesiumLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium + Levodopa interactionDietary FiberOral Drugs Minor
Interaction Summary
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Dietary Fiber + Levodopa interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Immune Defense Mixed Berry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dietary Fiber
Carbamazepine (Tegretol)
Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.
Lithium
Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.
Metformin (Glucophage)
Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
Olanzapine (Zyprexa)
Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.
Digoxin (Lanoxin)
Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.
Ethinyl Estradiol
Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.
Oral Drugs
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Magnesium
Levodopa/Carbidopa (Sinemet)
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.
Aminoglycoside Antibiotics
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.
Antacids
Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.
Bisphosphonates
Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Calcium Channel Blockers
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.
Digoxin
Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.
Potassium-Sparing Diuretics
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.
Quinolone Antibiotics
Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Skeletal Muscle Relaxants
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.
Sulfonylureas
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.
Tetracycline Antibiotics
Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.
Anticoagulant/Antiplatelet Drugs
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.
Gabapentin (Neurontin)
Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Sevelamer (Renagel, Renvela)
Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.
Vitamin C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Zinc
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.
Cephalexin (Keflex)
Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.
Cisplatin (Platinol-Aq)
Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.
Integrase Inhibitors
Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.
Penicillamine (Cuprimine, Depen)
Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.
Quinolone Antibiotics
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.
Ritonavir (Norvir)
Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.
Tetracycline Antibiotics
Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.
Amiloride (Midamor)
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.
Atazanavir (Reyataz)
Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Brand information
Manufacturer and brand details for Immune Defense Mixed Berry, from the product label.
Country Farms
- Name
- Country Farms
- Street Address
- 10 Henderson Drive
- City
- West Caldwell
- State
- NJ
- ZipCode
- 07006
- Web Address
- CountryFarms.com
Immune Defense Mixed Berry by Country Farms: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Immune Defense Mixed Berry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Psyllium
Interacts with 2,025 drugsBlack psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...
Read the full Black Psyllium monograph → Herb & supplement monographZinc
Interacts with 67 drugsZinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...
Read the full Zinc monograph → Herb & supplement monographMagnesium
Interacts with 295 drugsMagnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...
Read the full Magnesium monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph → Herb & supplement monographVitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph →Sources & How We Checked
Immune Defense Mixed Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 804 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Psyllium 18 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
- Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
- Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
- Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
- Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
- Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
- Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
- Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed
Zinc 88 references
- Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
- Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
- Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
- Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
- Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
- Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
- Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
- Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
- Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
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Lion's Mane Mushroom 6 references
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See these in context on the Lion's Mane Mushroom monograph →
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