Major interaction on record — check this product against your medications before combining. Based on 4 of 10 ingredients. Check your meds →
Dietary supplement

TrueCirc Ingredients & Drug Interactions

by NatureCity

TrueCirc label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TrueCirc against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

TrueCirc is a dietary supplement by NatureCity with 10 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 791 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin E, AstaReal, EVNol SupraBio. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against TrueCirc by NatureCity

Ask about any prescription or over-the-counter medication and we check it for interactions with TrueCirc by NatureCity — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of TrueCirc by NatureCity

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • “Total Natural D-Mixed Palm Tocotrienols” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

TrueCirc contains 10 active ingredients. The bulk of the formula is vitamin E in multiple forms: Vitamin E itself, four individual tocotrienols (D-Gamma, D-Alpha, D-Delta, and D-Beta), and EVNol SupraBio (another tocotrienol blend) plus Total Natural D-Mixed Palm Tocotrienols.

You'll also find Astaxanthin (branded as AstaReal), Vitamin K, Phytosterol Complex, and Plant Squalene. The softgel capsule is made with olive oil, gelatin, glycerin, yellow beeswax, and purified water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Antioxidant support and cardiovascular health.
  • We looked for evidence on: Cardiovascular disease (CVD), Atherosclerosis, Hypercholesterolemia, Hyperlipidemia, Hypertension, Heart failure — and 4 related terms.
  • The closest evidence on file: Vitamin E is rated "Possibly Ineffective" for Angina (Natural Medicines).
  • Also on file: Vitamin E is rated "Possibly Ineffective" for Atherosclerosis, Congestive heart failure (CHF).
  • Also on file: Tocotrienols is rated "Possibly Ineffective" for Hypercholesterolemia.

For vitamin E, the evidence is strongest for vitamin E deficiency and a rare condition called ataxia with vitamin E deficiency (AVED) — both rated Effective. There's Possibly Effective evidence for Alzheimer's disease, beta-thalassemia, G6PD deficiency (glucose-6-phosphate dehydrogenase deficiency), and intracranial hemorrhage.

For astaxanthin (AstaReal), the evidence is Insufficient — we don't have enough reliable data to rate it for age-related cognitive decline, macular degeneration, aging skin, Alzheimer's, athletic performance, or carpal tunnel syndrome. Tocotrienols (EVNol SupraBio) are rated Possibly Effective for diabetes but Possibly Ineffective for high cholesterol; evidence is Insufficient for alopecia areata and breast cancer.

For vitamin K, the evidence is Effective for conditions involving clotting-factor deficiency and Possibly Effective for osteoporosis.

The evidence, ingredient by ingredient Vitamin E Astaxanthin Vitamin K Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E from food and normal dietary amounts is safe, but the safety notes caution that high-dose long-term supplements may raise the risk of bleeding and other harms. Serious adverse effects from vitamin E are rare but include bleeding, hemorrhagic stroke, and cardiovascular problems.

There's particular concern about a higher risk of hemorrhagic stroke in male smokers who took synthetic vitamin E for 5–8 years, though other studies of 1.4–4.5 years showed no increased stroke risk. High doses increase bleeding risk, especially in people with vitamin K deficiencies or those taking blood thinners.

Astaxanthin appears well tolerated in studies, but long-term safety data are limited. Reported adverse effects include abdominal pain, diarrhea, and red-colored stools; at higher doses (40 mg daily), severe stomach pain was reported.

The safety data advise against astaxanthin in pregnancy and while breastfeeding. Tocotrienols (EVNol SupraBio) are well tolerated in trials with no reported adverse effects, though long-term safety isn't well established; avoid supplemental doses in pregnancy and use cautiously while breastfeeding.

Vitamin K is generally well tolerated and safe in food amounts; you may experience mild nausea, diarrhea, or stomach upset. It is Likely Safe in pregnancy.

Side effects, ingredient by ingredient Vitamin E Astaxanthin Vitamin K Tocotrienols

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Vitamin E, Vitamin K, Astaxanthin, Tocotrienols.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 792 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking TrueCirc, double-check these medication types with your pharmacist: warfarin and other blood thinners (anticoagulants) — Major concern with vitamin K; antiplatelet drugs like aspirin or clopidogrel and other anticoagulants — Moderate risk of bleeding from vitamin E compounds; chemotherapy drugs that work by generating free radicals (alkylating agents like cyclophosphamide, and antitumor antibiotics like doxorubicin) — Moderate concern that vitamin E may reduce their effectiveness; cyclosporine (an immunosuppressant) — Moderate risk that vitamin E may increase its levels; drugs metabolized by CYP3A4 and CYP2B6 liver enzymes — Moderate to theoretical risk of reduced effectiveness from vitamin E and astaxanthin; and niacin — Minor concern that vitamin E may reduce its cholesterol-raising effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

TrueCirc is primarily a vitamin E formula with added K, astaxanthin, and tocotrienols. If you take warfarin or any blood thinner, talk to your pharmacist or doctor before starting — vitamin K here can interfere with your medication's effectiveness.

If you're on chemotherapy, immunosuppressants, or drugs metabolized by your liver, check your specific medications first. It may be reasonable for someone with a documented vitamin E deficiency, but the evidence for other uses is limited or uncertain.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TrueCirc, straight from the product label.

Brand NatureCity
Barcode (UPC) 859003007178
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 283374
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TrueCirc by NatureCity, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
859003007178
IngredientAmount% DV
Vitamin E20 mg133%
D-Gamma Tocotrienol46.2 mg--
D-Alpha-Tocotrienol30.9 mg--
D-Delta-Tocotrienol17.3 mg--
Phytosterol Complex8.6 mg--
D-Beta-Tocotrienol5.6 mg--
Plant Squalene18.5 mg--
AstaReal6 mg--
Vitamin K50 mcg63%
EVNol SupraBio636 mg--
Total Natural D-Mixed Palm Tocotrienols100 mg--

Other ingredients: Olive Oil, Gelatin, Glycerin, Yellow Beeswax, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Each serving contains two (2) softgels. Take one (1) to two (2) servings per day or as directed by your health care practitioner.

Formula

EVNol SupraBio from red palm oil MenaQ7 Natural vitamin K2 AstaReal The natural astaxanthin of choice

Precautions

Keep out of reach of children

Do not use if seal is broken or missing

Warning: If you are using a blood thinning medication, pregnant or lactating, consult your physician or healthcare professional prior to use.

Storage

Store in a cool dry place

Formulation

Non GMO Gluten free

Artery health support

Seals/Symbols

Assembled in the USA

General Statements

To re-order call toll-free: 1-800-593-2563

BPA free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

EVNol SupraBio is a trademark of ExcelVite Inc. and protected by US patent no. 6,596,306. / AstaReal is a registered trademark of Fuji Chemical Industries Co., Ltd. / MenaQ7 is a registered trademark of NattoPharma, Norway; patented in the United States and Canada.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TrueCirc by NatureCity label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TrueCirc label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TrueCirc by NatureCity

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
20 mg per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Phytosterol Complex

8.6 mg per serving

Plant Squalene

18.5 mg per serving

AstaReal

Interacts with
671 drugs
6 mg per serving Form: Astaxanthin, Natural

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

AstaReal monograph & interactions

Vitamin K

Interacts with
2 drugs
50 mcg per serving Form: Vitamin K2

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K monograph & interactions

EVNol SupraBio

Interacts with
122 drugs
636 mg per serving Form: Palm Tocotrienol Complex

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

EVNol SupraBio monograph & interactions

Total Natural D-Mixed Palm Tocotrienols

100 mg per serving

Other (inactive) ingredients: Olive Oil, Gelatin, Glycerin, Yellow Beeswax, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

TrueCirc by NatureCity Drug Interactions

Want to check YOUR meds against TrueCirc?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
791Drugs
2 Major 788 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764
AstaReal 671
EVNol SupraBio 122
Vitamin K 2

Individual Drug Interactions

The ingredients in TrueCirc interact with 791 drugs. Click any drug to see the details.

4 of the 10 ingredients in TrueCirc interact with drugs. Each result below shows which ingredient is responsible. Vitamin E AstaReal EVNol SupraBio Vitamin K

Each ingredient & the kinds of drugs it affects

For each ingredient in TrueCirc with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

AstaReal2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
AstaReal full monograph & interactions

EVNol SupraBio1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
EVNol SupraBio full monograph & interactions

Vitamin K1 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TrueCirc, from the product label.

NatureCity

See all NatureCity products
Name
NatureCity
Street Address
990 S. Rogers Circle
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-800-593-2563
Web Address
www.naturecity.com
Pharmacist Counseling Corner

TrueCirc by NatureCity: Common Questions

Does TrueCirc by NatureCity interact with any medications?
Yes. Based on its ingredients, TrueCirc has a known interaction with 791 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TrueCirc contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take TrueCirc if I'm pregnant?
The vitamin E, tocotrienols, and astaxanthin in this product don't have enough safety data in pregnancy — the safety notes advise against astaxanthin and supplemental tocotrienol doses during pregnancy. Vitamin K alone is rated Likely Safe in pregnancy. Talk with your doctor or pharmacist before starting this product if you're pregnant or planning to become pregnant.
Can I take TrueCirc while breastfeeding?
Normal dietary amounts of vitamin E are fine, but the product's high-dose supplements should be checked with your doctor first. Astaxanthin isn't recommended while breastfeeding, and tocotrienols should be avoided unless your doctor advises otherwise. Vitamin K's safety while breastfeeding isn't fully established. Check with your pharmacist or doctor before using this product.
What are tocotrienols, and why are they in this product?
Tocotrienols are a form of vitamin E. This product contains multiple tocotrienol types (D-Gamma, D-Alpha, D-Delta, D-Beta) plus additional tocotrienol blends. They're included because they carry some of the same properties as vitamin E — in particular, Possibly Effective evidence exists for diabetes, though the evidence is Insufficient for most other uses the product might be promoted for.
What is astaxanthin (AstaReal), and does it work?
Astaxanthin is a red pigment compound from algae. In TrueCirc it's branded as AstaReal. The evidence for astaxanthin isn't established — we don't have enough reliable data to rate it for age-related cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, or carpal tunnel syndrome.
What are the most common side effects of TrueCirc?
Vitamin E is generally well tolerated with few side effects. Astaxanthin may cause abdominal pain, diarrhea, and red-colored stools; at higher doses, severe stomach pain was reported in a small number of trial participants. Tocotrienols have shown no adverse effects in clinical trials. Vitamin K may cause mild nausea, diarrhea, or stomach upset.
If I'm taking niacin for cholesterol, should I avoid TrueCirc?
There's a Minor interaction — vitamin E in this product might decrease the cholesterol-raising effect of niacin on your 'good' (HDL) cholesterol. This isn't a reason to avoid the product outright, but mention it to your pharmacist or doctor so they can monitor your niacin's effectiveness if needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TrueCirc label
Go deeper

The Full Monographs Behind TrueCirc’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph → Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph → Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

TrueCirc's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 82 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
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Astaxanthin 3 references
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Vitamin K 11 references
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Tocotrienols 4 references
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  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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