Cyclophosphamide

Name: Cyclophosphamide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

88 interactions 1,015 cited references

Also sold as: Cytoxan® Frindovyx

About Cyclophosphamide

Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that fir… Read the full Cyclophosphamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Varicella Virus Vaccine, Live Yellow Fever Vaccine Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live

9 Contraindicated 47 Major 31 Moderate 1 Minor

All (88) Contraindicated (9) Major (47) Moderate (31) Minor (1)

Moderate

Cyclophosphamide Sars-Cov-2 (Covid-19) Vaccine, Mrna (Moderna) Decreased immune response to COVID-19 vaccine Details Cyclophosphamide Sars-Cov-2 (Covid-19) Vaccine, Mrna (Pfizer) Decreased immune response to COVID-19 vaccine Details Cyclophosphamide Sparsentan Filspari Reduced CYP2B6 substrate exposure and reduced efficacy of CYP2B6 substrate Details Cyclophosphamide Succinylcholine Anectine An increased risk of potentiated succinylcholine efficacy Details Cyclophosphamide Thiotepa Tepadina Reduced cyclophosphamide conversion to the active metabolite 4-hydroxycyclophosphamide and reduced efficacy of cyclophosphamide Details Cyclophosphamide Trichlormethiazide Increased risk of myelosuppression Details Cyclophosphamide Xipamide Increased risk of myelosuppression Details

Minor

Cyclophosphamide Indomethacin Indocin Fluid retention Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.