Demeclocycline

63 interactions 111 cited references
Also sold as: Declomycin®
About Demeclocycline

Demeclocycline is used to treat infections caused by bacteria includingpneumonia and other respiratory tract infections;; certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used al… Read the full Demeclocycline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Bacampicillin Penicillin G Benzathine Injection Penicillin V Potassium Dicloxacillin Cloxacillin
1 Contraindicated 39 Major 23 Moderate
All (63) Contraindicated (1) Major (39) Moderate (23)

Contraindicated

Demeclocycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Demeclocycline Isotretinoin Absorica An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Demeclocycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Demeclocycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Demeclocycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Demeclocycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Demeclocycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Demeclocycline Bacampicillin Decreased antibacterial effectiveness Details Demeclocycline Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Demeclocycline Cloxacillin Decreased antibacterial effectiveness Details Demeclocycline Dicloxacillin Decreased antibacterial effectiveness Details Demeclocycline Digoxin Cardoxin® Increased digoxin levels and digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Demeclocycline Ethinyl Estradiol Reduced ethinyl estradiol exposure, reduced efficacy of ethinyl estradiol and an increased risk of breakthrough bleeding and/or co... Details Demeclocycline Etretinate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Demeclocycline Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Demeclocycline Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Demeclocycline Magnesium Sulfate May reduce absorption of tetracycline antibiotics Details Demeclocycline Methicillin Decreased antibacterial effectiveness Details Demeclocycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Demeclocycline Methoxyflurane Increased risk for renal toxicity Details Demeclocycline Nafcillin Decreased antibacterial effectiveness Details Demeclocycline Oxacillin Decreased antibacterial effectiveness Details Demeclocycline Palovarotene Sohonos Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Demeclocycline Penicillin G Decreased antibacterial effectiveness Details Demeclocycline Penicillin G Benzathine Decreased antibacterial effectiveness Details Demeclocycline Penicillin G Procaine Decreased antibacterial effectiveness Details Demeclocycline Penicillin V Decreased antibacterial effectiveness Details Demeclocycline Piperacillin Decreased antibacterial effectiveness Details Demeclocycline Pivampicillin Decreased antibacterial effectiveness Details Demeclocycline Porfimer Excessive intracellular damage in photosensitized tissues Details Demeclocycline Sultamicillin Decreased antibacterial effectiveness Details Demeclocycline Temocillin Decreased antibacterial effectiveness Details Demeclocycline Tretinoin Altreno An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Demeclocycline Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Demeclocycline Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Demeclocycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Demeclocycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Demeclocycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Demeclocycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Demeclocycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

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