Gabapentin Enacarbil

26 interactions 2 explained in plain English

Also sold as: Horizant

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Buprenorphine Esketamine Nasal Spray Fentanyl Transdermal Patch Orlistat Hydromorphone Rectal

25 Major 1 Moderate

All (26) Major (25) Moderate (1)

Major

Gabapentin Enacarbil Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory depression Details Gabapentin Enacarbil Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Gabapentin Enacarbil Aripiprazole Injection Abilify An increased risk of respiratory depression Details Gabapentin Enacarbil Asenapine Transdermal Patch Secuado An increased risk of respiratory depression Details Gabapentin Enacarbil Butorphanol Injection Butorphic An increased risk of respiratory depression Details Gabapentin Enacarbil Butorphanol Nasal Spray Stadol® NS An increased risk of respiratory depression Details Gabapentin Enacarbil Calcifediol Rayaldee Altered serum levels of calcifediol Details Gabapentin Enacarbil Cetirizine Injection Aller-Tec An increased risk of respiratory depression Details Gabapentin Enacarbil Cetirizine Ophthalmic Zerviate An increased risk of respiratory depression Details Gabapentin Enacarbil Diazepam Nasal Spray Valtoco An increased risk of respiratory depression Details Gabapentin Enacarbil Diazepam Rectal Diastat An increased risk of respiratory depression Details Gabapentin Enacarbil Diphenhydramine Injection Banophen An increased risk of respiratory depression Details Gabapentin Enacarbil Diphenhydramine Topical Afterbite with Antihistamine An increased risk of respiratory depression Details Gabapentin Enacarbil Esketamine Nasal Spray Spravato An increased risk of respiratory depression Details Gabapentin Enacarbil Fentanyl Transdermal Patch Duragesic® An increased risk of respiratory depression Details Gabapentin Enacarbil Hydromorphone Injection Dilaudid An increased risk of respiratory depression Details Gabapentin Enacarbil Hydromorphone Rectal available generically An increased risk of respiratory depression Details Gabapentin Enacarbil Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Gabapentin Enacarbil Lacosamide Injection Motpoly An increased risk of CNS depression Details Gabapentin Enacarbil Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Gabapentin Enacarbil Midazolam Nasal Spray Nayzilam An increased risk of respiratory depression Details Gabapentin Enacarbil Midazolam Injection Nayzilam An increased risk of respiratory depression Details Gabapentin Enacarbil Morphine Injection Astramorph® PF An increased risk of respiratory depression Details Gabapentin Enacarbil Nalbuphine Injection Nubain® An increased risk of respiratory depression Details Gabapentin Enacarbil Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Gabapentin Enacarbil Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.