Levonorgestrel

234 interactions 370 cited references

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About Levonorgestrel

A progestin used as emergency contraception to prevent pregnancy after unprotected sexual intercourse. Read the full Levonorgestrel drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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6 Contraindicated 191 Major 36 Moderate 1 Minor

All (234) Contraindicated (6) Major (191) Moderate (36) Minor (1)

Moderate

Levonorgestrel Amitriptyline Elavil Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Acitretin Soriatane® Loss of contraceptive effectiveness Details Levonorgestrel Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Levonorgestrel Diazepam Nasal Spray Valtoco Diazepam toxicity (CNS depression, hypotension) Details Levonorgestrel Diazepam Rectal Diastat Diazepam toxicity (CNS depression, hypotension) Details Levonorgestrel Dofetilide Tikosyn Increased dofetilide exposure Details Levonorgestrel Leflunomide Arava Increased levonorgestrel exposure Details Levonorgestrel Amiodarone Nexterone Increased hormonal contraceptive exposure Details Levonorgestrel Artemether Reduced hormonal contraceptive exposure and an increased artemether/lumefantrine exposure Details Levonorgestrel Atazanavir Reyataz An increase in exposure to the combination contraceptive Details Levonorgestrel Desipramine Norpramin Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Diazepam Diastat Diazepam toxicity (CNS depression, hypotension) Details Levonorgestrel Dicumarol Decreased anticoagulant effectiveness Details Levonorgestrel Dothiepin Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Doxepin Prudoxin Attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Imipramine Possible attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Levonorgestrel Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Levonorgestrel Lamotrigine Lamictal Reduced lamoTRIgine exposure and an increased risk of seizures Details Levonorgestrel Levothyroxine Ermeza Reduced thyroid hormone replacement exposure Details Levonorgestrel Licorice Increased risk of fluid retention and elevated blood pressure Details Levonorgestrel Liothyronine Cytomel Reduced thyroid hormone replacement exposure Details Levonorgestrel Lofepramine Attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Lorazepam Ativan Decreased lorazepam effectiveness Details Levonorgestrel Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Levonorgestrel Nortriptyline Attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Perampanel FYCOMPA Decreased contraceptive effectiveness Details Levonorgestrel Protriptyline Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Selegiline Anipryl An increase in selegiline oral bioavailability and an increased risk of selegiline adverse reactions Details Levonorgestrel Succinylcholine Anectine Prolongation of neuromuscular blockade Details Levonorgestrel Tacrine An increased risk of tacrine adverse effects Details Levonorgestrel Temazepam Restoril Reduced temazepam exposure and reduced efficacy of temazepam Details Levonorgestrel Teriflunomide Aubagio Increased levonorgestrel exposure Details Levonorgestrel Triazolam Halcion Triazolam toxicity (excessive sedation, confusion) Details Levonorgestrel Trimipramine Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Zolmitriptan Zomig An increased risk of zolmitriptan adverse effects Details

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