Maprotiline
22 interactions 183 cited referencesMaprotiline is used to treat depression, bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods), and anxiety. Maprotiline is in a class of medications called tetracyclic antidepressants. It works by increasing the amounts of certain natura… Read the full Maprotiline drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Contraindicated
Maprotiline Linezolid Injection Zyvox An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Bromopride Increased risk of extrapyramidal reactions Details Maprotiline Isocarboxazid Marplan An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Linezolid Zyvox An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Mavorixafor Xolremdi Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Maprotiline Methylene Blue Provayblue An increased risk of serotonin syndrome (labile blood pressure, hyperthermia, neuromuscular abnormalities, mental status changes,... Details Maprotiline Ozanimod An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Phenelzine Nardil An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Procarbazine An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Rasagiline Azilect An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Safinamide Xadago Increased risk of serotonin syndrome Details Maprotiline Selegiline Anipryl An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Maprotiline Tranylcypromine Parnate An increased risk of severe or life threatening reactions, like serotonergic syndrome, neurotoxicity, seizures DetailsMajor
Maprotiline Sertraline Increased CYP2D6 substrate exposure Details Maprotiline Hydroxychloroquine Plaquenil An increased risk of seizures Details Maprotiline Bupropion Aplenzin Increased risk of seizures Details Maprotiline Clomipramine Anafranil Increased risk of seizures Details Maprotiline Lumefantrine Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse reactions Details Maprotiline Paroxetine Paxil Increased CYP2D6 substrate exposure Details Maprotiline Ranolazine Aspruzyo Increased CYP2D6 substrates exposure Details Maprotiline Tramadol ConZip An increased risk of seizure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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