Tigecycline

26 interactions 1 explained in plain English
Also sold as: Tygacil
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Penicillin G Benzathine Injection Estradiol Transdermal Patch Penicillin V Potassium Penicillin G Procaine Injection
1 Contraindicated 21 Major 4 Moderate
All (26) Contraindicated (1) Major (21) Moderate (4)

Contraindicated

Tigecycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Tigecycline Isotretinoin Absorica Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tigecycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Tigecycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Tigecycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Tigecycline Azathioprine Azasan An increased risk of hepatotoxicity Details Tigecycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tigecycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tigecycline Estradiol Delestrogen Decreased contraceptive effectiveness Details Tigecycline Estradiol Topical Divigel Decreased contraceptive effectiveness Details Tigecycline Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Tigecycline Levonorgestrel After banger Decreased contraceptive effectiveness Details Tigecycline Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Tigecycline Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Tigecycline Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Tigecycline Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Tigecycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tigecycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tigecycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Tigecycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Tigecycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Tigecycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

Moderate

Tigecycline Cyclosporine Injection Atopica May increase serum trough concentrations of calcineurin inhibitors Details Tigecycline Cyclosporine Ophthalmic Cequa May increase serum trough concentrations of calcineurin inhibitors Details Tigecycline Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Tigecycline Lanthanum Fosrenol® Reduced bioavailability of tetracyclines Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.