Tigecycline

Name: Tigecycline Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

26 interactions 1 explained in plain English

Also sold as: Tygacil

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Penicillin G Benzathine Injection Estradiol Transdermal Patch Penicillin V Potassium Penicillin G Procaine Injection

1 Contraindicated 21 Major 4 Moderate

All (26) Contraindicated (1) Major (21) Moderate (4)

Moderate

Tigecycline Cyclosporine Injection Atopica May increase serum trough concentrations of calcineurin inhibitors Details Tigecycline Cyclosporine Ophthalmic Cequa May increase serum trough concentrations of calcineurin inhibitors Details Tigecycline Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Tigecycline Lanthanum Fosrenol® Reduced bioavailability of tetracyclines Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.