Drug & supplement interaction

Chlorophyllin + Granisetron

Granisetron brand names: Kytril, Sustol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chlorophyllin and Granisetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Granisetron states a food rule worth keeping to.

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Interaction report

Chlorophyllin and Granisetron

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Granisetron and Chlorophyllin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chlorophyllin safety at a glance

Chlorophyllin overall Use caution Generally well tolerated short-term, but quality evidence and long-term safety data are limited.
Pregnancy Avoid Not enough reliable safety data, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoidance is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Granisetron and Chlorophyllin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Granisetron

Interactions in our licensed database are recorded against drug classes, not just single drug names. Granisetron is filed under 3 classifications — serotonergic drugs, serotonergic drugs, oral drugs. Chlorophyllin has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Granisetron’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chlorophyllin Does Interact With Other Medications

Chlorophyllin has 335 moderate known drug interactions in our database — Granisetron isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Granisetron)
Taking anything else?

Check Another of Your Medications Against Chlorophyllin

Covers the 2,830 medications we’ve checked against Chlorophyllin. Pick one to open its full report.

What to actually watch for

What Chlorophyllin Itself Has Been Linked To

This is not an interaction — nothing below involves Granisetron. It is the side-effect record for Chlorophyllin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Chlorophyllin, this list is the first place to look.

  • Sun sensitivity / A skin rash Additional detail

    “Since chlorophyllin is a semi-synthetic derivative of chlorophyll, there is some concern that it could cause similar adverse effects. Topically, chlorophyll cream has been reported to cause dermatitis. Orally, chlorophyll can cause photosensitization. In case reports, oral consumption of chlorophyll has been associated with the development of pseudoporphyria.”

    Chlorophyllin · Natural Medicines adverse-effect record, reported in dermatitis.

    5 sources cited
    1. 41912. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
    2. 1326. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
    3. 93892. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
    4. 97933. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
    5. 101235. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Chlorophyllin — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Granisetron’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Granisetron column appears here.

How to take them

Some Granisetron Products Have a Food Rule — Chlorophyllin Should Not Break It

At least one FDA label for a product containing Granisetron says to take it on an empty stomach. Most supplements — Chlorophyllin included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Granisetron on its own and move Chlorophyllin to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Granisetron products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Recommended Dosage ( 2.2 ): The recommended dosage in adults is 10 mg administered as a single subcutaneous injection at least 30 minutes before the start of emetogenic chemotherapy on Day 1.

From the Dosage and Administration section of the FDA label we read for Granisetron — where that label names a specific product, the instruction is that product's. See the Granisetron drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Granisetron Is Prescribed For, and What Chlorophyllin Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Granisetron is a prescription medicine with approved uses on its FDA label. Chlorophyllin is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Granisetron is prescribed for: Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days. Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults.

Read the rest of what Granisetron is prescribed for

Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.

Chlorophyllin has been studied for:

  • Cancer studied, not established Chlorophyllin has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Chlorophyllin for cancer

    Although there is interest in using oral chlorophyllin for cancer, there is insufficient reliable information about the clinical effects of chlorophyllin for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Granisetron on your own; if you are taking Chlorophyllin for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Granisetron

This page covers Chlorophyllin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Granisetron page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).

By severity: 2 major · 25 moderate · 11 minor.

From our pharmacist’s overview on the Granisetron page

“Granisetron (Kytril, Sustol) blocks serotonin signals to stop nausea from chemotherapy and surgery, and this is a list that warrants real caution before you add a supplement to it. Most of the entries raise serotonin themselves, and stacking them on a serotonin-acting drug can push toward serotonin syndrome, a dangerous overload of tha…”

Reviewed by 2 · Jul 18, 2026

Open the Granisetron interaction page

One more smart check

Taking Chlorophyllin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 357 real supplement products containing Chlorophyllin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chlorophyllin. Even though Chlorophyllin itself has no known interaction with Granisetron, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chlorophyllin and Granisetron Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chlorophyllin
Top half

#510 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Granisetron
Steady interest

#2,026 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chlorophyllin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chlorophyllin and Granisetron records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chlorophyllin

What is Chlorophyllin?

Chlorophyllin
  • Body and breath odor control
  • Wound and skin care
  • Internal deodorant for ostomy or incontinence
  • Detoxification claims
  • Digestive support

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a deodorizing agent, while many popular claims like detoxification and digestive benefits are not well proven. It is generally considered safe for short-term use, but talk to your pharmacist or doctor before starting it, especially during pregnancy or breastfeeding.

Semi-synthetic derivative of chlorophyll (originally from green plant leaves) · Tablets, capsules, liquid drops, topical ointments and sprays

An interaction check asks whether these two react with each other — it does not ask whether Chlorophyllin is a good idea for someone in your situation. Here is what our Chlorophyllin record says about it on its own.

Chlorophyllin: dosing

There is no official standardized dose for chlorophyllin, and the amount used in studies has varied. Products come in different strengths and forms, so the right amount depends on the specific product and how it is being used.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Chlorophyllin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chlorophyllin monograph & all interactions
Medication

About Granisetron

What Is Granisetron Used For?

Brand names: Kytril, Sustol

Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days.

Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults. Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.

See full Granisetron drug information
Keep checking

Other Drugs & Chlorophyllin

Browse every other medication we’ve checked against Chlorophyllin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Chlorophyllin page.

No interaction 2,494 drugs checked — show the list

We also checked Chlorophyllin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Chlorophyllin list.

See the full Chlorophyllin interactions page
See every supplement checked against Granisetron, ranked by severity
Evidence & sources

Chlorophyllin References

The 6 references that drive our Chlorophyllin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
  2. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  3. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
  4. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  5. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
  6. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chlorophyllin and Granisetron Together: Common Questions

Is it safe to take Chlorophyllin with Granisetron?
We do not list a known interaction between Chlorophyllin and Granisetron. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Chlorophyllin and Granisetron at the same time of day?
At least one FDA label for a product containing Granisetron says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Granisetron on its own and move Chlorophyllin to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Are Chlorophyllin and Granisetron used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Chlorophyllin in each. That is a conversation for your prescriber, especially if Granisetron is being adjusted to a target.
How was the Chlorophyllin and Granisetron combination checked?
Interactions in our licensed database are recorded against drug classes. Granisetron is filed under 3 classifications, and Chlorophyllin has documented interactions with 1 drug class — none of Granisetron's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chlorophyllin interact with any other medications?
Yes. Chlorophyllin has 335 documented drug interactions in our database — Granisetron is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Granisetron interact with any supplements?
Yes. Granisetron has documented interactions with 38 supplements in our database — Chlorophyllin is not one of them. The Granisetron interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chlorophyllin monograph Uses, safety profile, and every drug interaction in one place Granisetron drug information The full plain-English guide to this medication Granisetron supplement interactions Every supplement checked against Granisetron, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Granisetron and Chlorophyllin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.