Drug & supplement interaction

Dolomite + Chlorpheniramine, Methscopolamine, Pseudoephedrine

Chlorpheniramine, Methscopolamine, Pseudoephedrine brand names: Mescolor, Rescon-Mx, Xiral.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Dolomite and Chlorpheniramine, Methscopolamine, Pseudoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dolomite and Chlorpheniramine, Methscopolamine, Pseudoephedrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chlorpheniramine, Methscopolamine, Pseudoephedrine and Dolomite in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dolomite safety at a glance

Dolomite overall Avoid Dolomite may be contaminated with heavy metals such as lead, arsenic, and mercury.
Pregnancy Avoid Avoid during pregnancy because of possible heavy metal contamination, especially lead.
Breastfeeding Possibly Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chlorpheniramine, Methscopolamine, Pseudoephedrine and Dolomite? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Chlorpheniramine, Methscopolamine, Pseudoephedrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Chlorpheniramine, Methscopolamine, Pseudoephedrine is filed under 12 classifications — including cytochrome p450 2d6 (cyp2d6) inhibitors, alpha-adrenergic agonists, stimulant drugs. Dolomite has documented interactions with 7 drug classes — the most serious being thiazide diuretics (major), bisphosphonates (moderate) and levothyroxine (synthroid, others) (moderate) — and none of Chlorpheniramine, Methscopolamine, Pseudoephedrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dolomite Does Interact With Other Medications

Dolomite has 56 major, 72 moderate known drug interactions in our database — Chlorpheniramine, Methscopolamine, Pseudoephedrine isn’t one of them. If you take anything else, check it against the full list below.

Major 56 Moderate 72 No known interaction 2,702 (incl. Chlorpheniramine, Methscopolamine, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Dolomite

Covers the 2,830 medications we’ve checked against Dolomite. Pick one to open its full report.

What to actually watch for

What Dolomite Itself Has Been Linked To

This is not an interaction — nothing below involves Chlorpheniramine, Methscopolamine, Pseudoephedrine. It is the side-effect record for Dolomite on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dolomite, this list is the first place to look. 4 entries are worth acting on rather than waiting out — marked below.

  • Muscle weakness / An irregular heartbeat / Confusion Worth acting on Additional detail

    “Dolomite contains calcium and magnesium. Large amounts of calcium carbonate can cause hypercalcemia and alkalosis (9). Furthermore, large amounts of magnesium may cause hypermagnesemia (9) with symptoms including thirst, hypotension, drowsiness, confusion, loss of tendon reflexes, muscle weakness, respiratory depression, cardiac arrhythmias, coma, cardiac arrest, and death (9).”

    Dolomite · Natural Medicines adverse-effect record, reported in arrhythmia.

    3 sources cited
    1. 9. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
    2. 48411. Steenkamp, V., Stewart, M. J., Curowska, E., and Zuckerman, M. A severe case of multiple metal poisoning in a child treated with a traditional medicine. Forensic Sci.Int. 8-28-2002;128(3):123-126. PubMed
    3. 997. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9. PubMed
  • Wheezing / Shortness of breath Worth acting on Additional detail

    “In a group of workers involved with digging and excavating dolomite, symptoms of exposure included cough, phlegm, wheezing, and shortness of breath. However, there was no increased risk in abnormalities in chest radiographs.”

    Dolomite · Natural Medicines adverse-effect record, reported in cough.

    1 source cited
    1. 96058. Neghab M, Abedini R, Soltanzadeh A, et al. Respiratory disorders associated with heavy inhalation exposure to dolomite dust. Iran Red Crescent Med J. 2012;14(9):549-57.
  • Seizures Worth acting on Additional detail

    “Orally, some dolomite products are contaminated with heavy metals including aluminum, arsenic, lead, mercury, nickel, and others that may cause heavy metal poisoning. Contaminated products have induced seizure activity in patients with otherwise well-controlled seizure disorders.”

    Dolomite · Natural Medicines adverse-effect record, reported in epilepsy.

    2 sources cited
    1. 997. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9. PubMed
    2. 11719. Scelfo GM, Flegal AR. Lead in calcium supplements. Environ Health Perspect 2000;108:309-19. PubMed
  • Kidney problems Worth acting on Additional detail

    “Dolomite contains calcium and magnesium. Calcium used orally can cause gastrointestinal irritation and constipation (9). Magnesium can cause gastrointestinal irritation, nausea, vomiting, and diarrhea (9,15).”

    Dolomite · Natural Medicines adverse-effect record, reported in constipation.

    4 sources cited
    1. 9. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
    2. 15. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
    3. 48411. Steenkamp, V., Stewart, M. J., Curowska, E., and Zuckerman, M. A severe case of multiple metal poisoning in a child treated with a traditional medicine. Forensic Sci.Int. 8-28-2002;128(3):123-126. PubMed
    4. 997. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9. PubMed
  • Increased thirst Additional detail

    Recorded for Dolomite in the same Natural Medicines adverse-effect record shown under Muscle weakness / An irregular heartbeat / Confusion above.

  • Bloating or gas Additional detail

    “Orally, dolomite may be unsafe due to concerns that it may be contaminated with heavy metals, including aluminum, arsenic, lead, mercury, nickel, and others.

    Most Common Adverse Effects:

    Orally: Belching, constipation, diarrhea, flatulence, nausea, and vomiting.

    Serious Adverse Effects (Rare):

    Orally: Dermatologic, gastrointestinal, hematologic, and neurologic disorders caused by heavy metals in contaminated dolomite…”

    Dolomite · Natural Medicines adverse-effect record, reported in constipation.

  • Cough Additional detail

    Recorded for Dolomite in the same Natural Medicines adverse-effect record shown under Wheezing / Shortness of breath above.

Showing the 10 most notable of 16 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Dolomite — expand a row for the licensed statement it rests on. We haven’t matched Chlorpheniramine, Methscopolamine, Pseudoephedrine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Chlorpheniramine, Methscopolamine, Pseudoephedrine.

Special populations

Dolomite in Pregnancy & Breastfeeding

Lactation Possibly Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Chlorpheniramine, Methscopolamine, Pseudoephedrine

This page covers Dolomite only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpheniramine, Methscopolamine, Pseudoephedrine page lists 231 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Henbane (major) and Lithium (major).

By severity: 10 major · 176 moderate · 45 minor.

From our pharmacist’s overview on the Chlorpheniramine, Methscopolamine, Pseudoephedrine page

“The three-drug combination of chlorpheniramine, methscopolamine, and pseudoephedrine (Mescolor, Rescon-Mx, Xiral) sits at the serious end of supplement interactions, with 231 ingredients on file and 10 rated major, and those ten are what to understand first. Most of the list splits into two problems.”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpheniramine, Methscopolamine, Pseudoephedrine interaction page

One more smart check

Taking Dolomite as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Dolomite, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dolomite. Even though Dolomite itself has no known interaction with Chlorpheniramine, Methscopolamine, Pseudoephedrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dolomite and Chlorpheniramine, Methscopolamine, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dolomite
Steady interest

#772 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorpheniramine, Methscopolamine, Pseudoephedrine
Top half

#1,221 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dolomite reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Dolomite and Chlorpheniramine, Methscopolamine, Pseudoephedrine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dolomite

What is Dolomite?

Dolomite
  • Source of calcium
  • Source of magnesium
  • Bone health support
  • Antacid for heartburn
  • Mineral supplementation

Dolomite is a natural mineral that provides both calcium and magnesium. However, many health authorities advise against using it because dolomite products have been found to contain heavy metals like lead, arsenic, and mercury, and safer, better-tested calcium and magnesium supplements are widely available.

Mineral rock (calcium magnesium carbonate) · Tablets, chewable tablets, powder, capsules

An interaction check asks whether these two react with each other — it does not ask whether Dolomite is a good idea for someone in your situation. Here is what our Dolomite record says about it on its own.

Dolomite: dosing

There is no well-established or recommended dose for dolomite, and we do not recommend it because of contamination concerns. They can help you reach your nutrient needs without the risk of heavy metals.

From our Dolomite monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dolomite monograph & all interactions
Keep checking

Other Drugs & Dolomite

Browse every other medication we’ve checked against Dolomite — both the ones with a known interaction and the ones without. Select any drug for the full detail.

56Major
72Moderate
0Minor
2,701No known interaction
56 Major 72 Moderate 2,701 No interaction
Major

56 interactions

Moderate

72 interactions

Showing 60 of 72 moderate interactions — see all 72 on the Dolomite page.

No interaction 2,701 drugs checked — show the list

We also checked Dolomite against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,701 medications checked with no known interaction — see the full Dolomite list.

See the full Dolomite interactions page
See every supplement checked against Chlorpheniramine, Methscopolamine, Pseudoephedrine, ranked by severity
Evidence & sources

Dolomite References

The 16 references that drive our Dolomite monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Roberts HJ. Potential toxicity due to dolomite and bonemeal. South Med J 1983;76:556-9. PubMed
  4. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  5. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  6. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  7. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  8. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  9. Ryan MP. Diuretics and potassium/magnesium depletion. Directions for treatment. Am J Med 1987;82:38-47.. PubMed
  10. Hollifield JW. Magnesium depletion, diuretics, and arrhythmias. Am J Med 1987;82:30-7.. PubMed
  11. Heidenreich O. Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects. Magnesium 1984;3:248-56..
  12. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  13. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  14. Scelfo GM, Flegal AR. Lead in calcium supplements. Environ Health Perspect 2000;108:309-19. PubMed
  15. Steenkamp, V., Stewart, M. J., Curowska, E., and Zuckerman, M. A severe case of multiple metal poisoning in a child treated with a traditional medicine. Forensic Sci.Int. 8-28-2002;128(3):123-126. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dolomite and Chlorpheniramine, Methscopolamine, Pseudoephedrine Together: Common Questions

Is it safe to take Dolomite with Chlorpheniramine, Methscopolamine, Pseudoephedrine?
We do not list a known interaction between Dolomite and Chlorpheniramine, Methscopolamine, Pseudoephedrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Dolomite and Chlorpheniramine, Methscopolamine, Pseudoephedrine combination checked?
Interactions in our licensed database are recorded against drug classes. Chlorpheniramine, Methscopolamine, Pseudoephedrine is filed under 12 classifications, and Dolomite has documented interactions with 7 drug classes — none of Chlorpheniramine, Methscopolamine, Pseudoephedrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dolomite interact with any other medications?
Yes. Dolomite has 128 documented drug interactions in our database — Chlorpheniramine, Methscopolamine, Pseudoephedrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Chlorpheniramine, Methscopolamine, Pseudoephedrine interact with any supplements?
Yes. Chlorpheniramine, Methscopolamine, Pseudoephedrine has documented interactions with 231 supplements in our database — Dolomite is not one of them. The Chlorpheniramine, Methscopolamine, Pseudoephedrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dolomite monograph Uses, safety profile, and every drug interaction in one place Chlorpheniramine, Methscopolamine, Pseudoephedrine supplement interactions Every supplement checked against Chlorpheniramine, Methscopolamine, Pseudoephedrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chlorpheniramine, Methscopolamine, Pseudoephedrine and Dolomite?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.