Drug & supplement interaction

Goji + Gilteritinib Fumarate

Gilteritinib Fumarate brand name: Xospata.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Goji has a moderate interaction with Gilteritinib Fumarate. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Goji and Gilteritinib Fumarate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Gilteritinib Fumarate

Gilteritinib Fumarate falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Goji interacts with.

Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.
In vitro research shows that goji berry juice inhibits CYP3A4 enzymes. Concomitant use with goji may decrease metabolism and increase levels of CYP3A4 substrates. However, this has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thinking on combining goji with your Xospata (gilteritinib). Your liver uses an enzyme called CYP3A4 to break down and clear this leukemia medication. Lab studies suggest goji, especially as concentrated juice or supplements, may slow that enzyme down a bit. If clearance slows, gilteritinib levels could creep up, which in theory means more of its side effects like fatigue, muscle and joint aches, swelling, diarrhea, or changes in your heart rhythm (QT prolongation).

I want to keep this in perspective. So far this is only seen in test-tube research, not in real patients, so we don't truly know if it matters in people. Eating goji berries as food is far less concentrated than a supplement. Since gilteritinib is a serious cancer drug, please run any goji supplement past your oncology team or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Liu R, Tam TW, Mao J, et al. In vitro activity of Lycium barbarum (Goji) against major human phase I metabolism enzymes. Complement Integr Med. 2016;13(3):257-265.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Goji Also Interacts With Other Medications

Goji has 2 major, 929 moderate, 68 minor known drug interactions in our database — the Gilteritinib Fumarate one above is one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 929 Minor 68 No known interaction 1,831 (incl. Gilteritinib Fumarate)
Taking anything else?

Check Another of Your Medications Against Goji

Covers the 2,830 medications we’ve checked against Goji. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Gilteritinib Fumarate

This page covers Goji only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Gilteritinib Fumarate page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 103 moderate · 38 minor.

From our pharmacist’s overview on the Gilteritinib Fumarate page

“Anyone taking gilteritinib fumarate (Xospata) is treating FLT3-mutated acute myeloid leukemia, and that alone makes this list one to approach with real vigilance. Of the 144 supplements and herbs on file, three carry a major rating, and they pull in different directions: grapefruit can raise gilteritinib levels, St.”

Reviewed by 2 · Jul 18, 2026

Open the Gilteritinib Fumarate interaction page

One more smart check

Taking Goji as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,738 real supplement products containing Goji, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Goji. Your product may carry other ingredients that interact with Gilteritinib Fumarate too, on top of Goji — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Goji and Gilteritinib Fumarate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Goji
Top 25%

#146 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Gilteritinib Fumarate
Steady interest

#2,299 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Goji

What is Goji?

Goji
  • General antioxidant support
  • Eye health
  • Immune support
  • Anti-aging and well-being
  • Blood sugar support

Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food. While they are popular for eye health, immune support, and general wellness, strong human evidence for most health claims is limited. Talk with your pharmacist or doctor before using concentrated goji supplements, especially if you take medications or are pregnant.

Read the full Goji monograph & all interactions
Medication

About Gilteritinib

What Is Gilteritinib Used For?

Brand name: Xospata

Xospata (gilteritinib) is used to treat adults with acute myeloid leukemia (AML) — a fast-moving blood and bone marrow cancer — when the disease has come back after prior treatment (relapsed) or stopped responding to treatment (refractory). It is only used when a laboratory test approved by the FDA has confirmed that the leukemia cells carry a FLT3 mutation, a genetic change that helps the cancer grow.

Because response can take time, treatment for at least 6 months is generally recommended as long as the disease is not progressing and side effects are manageable.

See full Gilteritinib drug information
Keep checking

Other Drugs & Goji

Browse every other medication we’ve checked against Goji — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
929Moderate
68Minor
1,830No known interaction
2 Major 929 Moderate 68 Minor 1,830 No interaction
Major

2 interactions

Moderate

929 interactions

Showing 60 of 929 moderate interactions — see all 929 on the Goji page.

Minor

68 interactions

Showing 60 of 68 minor interactions — see all 68 on the Goji page.

No interaction 1,830 drugs checked — show the list

We also checked Goji against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,830 medications checked with no known interaction — see the full Goji list.

See the full Goji interactions page
See every supplement checked against Gilteritinib Fumarate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Goji monograph › Uses, safety, and every drug interaction in one place Gilteritinib Fumarate supplement interactions › Every supplement checked against Gilteritinib Fumarate, ranked by severity Gilteritinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Goji and Gilteritinib Fumarate Together: Common Questions

Can you take Goji with Gilteritinib Fumarate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Goji and Gilteritinib Fumarate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Gilteritinib Fumarate and Goji?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.