Drug & supplement interaction

Indole-3-carbinol + Goserelin

Goserelin brand name: Zoladex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Indole-3-carbinol and Goserelin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Indole-3-carbinol and Goserelin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Goserelin and Indole-3-carbinol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Indole-3-carbinol safety at a glance

Indole-3-carbinol overall Use caution Likely fine in food amounts, but supplement doses are less studied and should be used cautiously.
Pregnancy Avoid Not enough safety data and possible hormone effects, so concentrated supplements should be avoided.
Breastfeeding Avoid Safety has not been established, so supplement use is not recommended while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Goserelin and Indole-3-carbinol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Goserelin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Goserelin is filed under a single classification — oral drugs. Indole-3-carbinol has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and estrogens (moderate) — and none of Goserelin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Indole-3-carbinol Does Interact With Other Medications

Indole-3-carbinol has 294 moderate known drug interactions in our database — Goserelin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 294 No known interaction 2,536 (incl. Goserelin)
Taking anything else?

Check Another of Your Medications Against Indole-3-carbinol

Covers the 2,830 medications we’ve checked against Indole-3-carbinol. Pick one to open its full report.

What to actually watch for

What Indole-3-carbinol Itself Has Been Linked To

This is not an interaction — nothing below involves Goserelin. It is the side-effect record for Indole-3-carbinol on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Indole-3-carbinol, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Unsteadiness Worth acting on Additional detail

    “Indole-3-carbinol has been associated with reports of unsteadiness and imbalance, especially at higher doses. An adult male taking 400 mg twice daily for treatment of recurrent respiratory papillomatosis developed imbalance and tremor after 10 days of treatment. This resolved when the dose was halved.”

    Indole-3-carbinol · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    2 sources cited
    1. 7172. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
    2. 93238. Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
  • Tremor or shakiness / Nausea Additional detail

    Recorded for Indole-3-carbinol in the same Natural Medicines adverse-effect record shown under Unsteadiness above.

  • Diarrhea Additional detail

    “Orally, indole-3-carbinol increases gastrointestinal motility and has been associated with diarrhea.”

    Indole-3-carbinol · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 93242. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
    2. 93243. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
  • A skin rash Additional detail

    “Orally, indole-3-carbinol has been associated with reports of rash. A woman taking indole-3-carbinol 375 mg daily for treatment of systemic lupus erythematosus (SLE) developed a generalized maculopapular rash which resolved when indole-3-carbinol was discontinued and recurred when it was restarted.”

    Indole-3-carbinol · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    2 sources cited
    1. 93242. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
    2. 93240. McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Indole-3-carbinol — expand a row for the licensed statement it rests on. We haven’t matched Goserelin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Goserelin.

Overlapping uses

What Goserelin Is Prescribed For, and What Indole-3-carbinol Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Goserelin is a prescription medicine with approved uses on its FDA label. Indole-3-carbinol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Indole-3-carbinol has been studied for:

  • Breast cancer studied, not established Indole-3-carbinol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Indole-3-carbinol for breast cancer

    Although there has been interest in using oral indole-3-carbinol for breast cancer, there is insufficient reliable information about the clinical effects of indole-3-carbinol for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Goserelin on your own; if you are taking Indole-3-carbinol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Goserelin

This page covers Indole-3-carbinol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Goserelin page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Goserelin page

“Goserelin (Zoladex) is given as a small implant under the skin, usually for prostate cancer, certain breast cancers, or endometriosis, and I would want anyone on it to read this list with real attention. All 17 flagged ingredients raise the same basic concern, changing how drugs are absorbed or retained, and the single major-rated one…”

Reviewed by 2 · Jul 18, 2026

Open the Goserelin interaction page

One more smart check

Taking Indole-3-carbinol as Part of a Dietary Supplement Product? Check It for Interactions

We hold 287 real supplement products containing Indole-3-carbinol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indole-3-carbinol. Even though Indole-3-carbinol itself has no known interaction with Goserelin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indole-3-carbinol and Goserelin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indole-3-carbinol
Top half

#382 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Goserelin
Steady interest

#1,686 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Indole-3-carbinol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Indole-3-carbinol and Goserelin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Indole-3-carbinol

What is Indole-3-carbinol?

  • Estrogen and hormone balance support
  • Breast and cervical health
  • Prostate health
  • Antioxidant and 'detox' support
  • General cancer-prevention interest

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effects. Most human evidence is preliminary or comes from lab and animal studies, so it should not be relied on to prevent or treat any disease. Talk to your pharmacist or doctor before using it, and avoid it in pregnancy and breastfeeding.

Brassicaceae · Derived from glucosinolates found in cruciferous vegetables (broccoli, cabbage, Brussels sprouts, cauliflower) · Capsules, tablets, softgels; sometimes combined with or compared to diindolylmethane (DIM)

An interaction check asks whether these two react with each other — it does not ask whether Indole-3-carbinol is a good idea for someone in your situation. Here is what our Indole-3-carbinol record says about it on its own.

Indole-3-carbinol: dosing

There is no officially established or standardized dose for I3C. Different products and studies have used different amounts, and there is no agreed-upon 'best' dose.The safest approach is to follow the directions on the product label and not exceed them. They can help you decide whether I3C is appropriate for you.

From our Indole-3-carbinol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Indole-3-carbinol monograph & all interactions
Medication

About Goserelin Implant

What Is Goserelin Implant Used For?

Brand name: Zoladex

  • Goserelin implant is used in combination with radiation therapy and other medications to treat localized prostate cancer and is used alone to treat the symptoms associated with advanced prostate cancer. It is also used to treat advanced breast cancer in certain women. It is also used to manage endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms) and to help with the treatment of abnormal bleeding of the uterus. Goserelin implant is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists. It works by decreasing the amount of certain hormones in the body.

Most-Reported Side Effects for Goserelin

From FAERS, the FDA’s public side-effect reporting system (13,351 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 1,340 reports
Fatigue 886 reports
Metastases to bone 698 reports
Neutropenia 656 reports
Nausea 600 reports
See full Goserelin Implant drug information
Keep checking

Other Drugs & Indole-3-carbinol

Browse every other medication we’ve checked against Indole-3-carbinol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
294Moderate
0Minor
2,535No known interaction
294 Moderate 2,535 No interaction
Moderate

294 interactions

Showing 60 of 294 moderate interactions — see all 294 on the Indole-3-carbinol page.

No interaction 2,535 drugs checked — show the list

We also checked Indole-3-carbinol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,535 medications checked with no known interaction — see the full Indole-3-carbinol list.

See the full Indole-3-carbinol interactions page
See every supplement checked against Goserelin, ranked by severity
Evidence & sources

Indole-3-carbinol References

The 9 references that drive our Indole-3-carbinol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
  2. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
  3. He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
  4. Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
  5. Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
  6. McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
  7. Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
  8. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
  9. Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Indole-3-carbinol and Goserelin Together: Common Questions

Is it safe to take Indole-3-carbinol with Goserelin?
We do not list a known interaction between Indole-3-carbinol and Goserelin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Indole-3-carbinol and Goserelin used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Indole-3-carbinol in each. That is a conversation for your prescriber, especially if Goserelin is being adjusted to a target.
How was the Indole-3-carbinol and Goserelin combination checked?
Interactions in our licensed database are recorded against drug classes. Goserelin is filed under 1 classification, and Indole-3-carbinol has documented interactions with 3 drug classes — none of Goserelin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Indole-3-carbinol interact with any other medications?
Yes. Indole-3-carbinol has 294 documented drug interactions in our database — Goserelin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Goserelin interact with any supplements?
Yes. Goserelin has documented interactions with 17 supplements in our database — Indole-3-carbinol is not one of them. The Goserelin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Indole-3-carbinol monograph Uses, safety profile, and every drug interaction in one place Goserelin Implant drug information The full plain-English guide to this medication Goserelin supplement interactions Every supplement checked against Goserelin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Goserelin and Indole-3-carbinol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.