Drug & supplement interaction

Jambolan + Metoprolol

Metoprolol brand names: Lopressor, Toprol XL.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Jambolan and Metoprolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Metoprolol states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Jambolan and Metoprolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metoprolol and Jambolan in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jambolan safety at a glance

Jambolan overall Use caution The fruit is widely eaten as food, but concentrated supplement doses are not well studied.
Pregnancy Avoid Not enough safety data for medicinal amounts, so avoid supplements during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided in supplement form.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metoprolol and Jambolan? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metoprolol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metoprolol is filed under 6 classifications — including beta-blockers, antihypertensive drugs, cytochrome p450 2d6 (cyp2d6) substrates. Jambolan has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), cytochrome p450 2c9 (cyp2c9) substrates (moderate) and sitagliptin (januvia) (minor) — and none of Metoprolol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jambolan Does Interact With Other Medications

Jambolan has 186 moderate known drug interactions in our database — Metoprolol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 186 No known interaction 2,644 (incl. Metoprolol)
Taking anything else?

Check Another of Your Medications Against Jambolan

Covers the 2,830 medications we’ve checked against Jambolan. Pick one to open its full report.

What to actually watch for

What Metoprolol’s Own FDA Label Lists

This is not an interaction — none of it involves Jambolan. These are the most notable effects listed in the ADVERSE REACTIONS section of Metoprolol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Memory problems Worth acting on
  • A slow heartbeat Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Heart failure Worth acting on
  • Fainting Worth acting on
  • Wheezing Worth acting on
  • Confusion Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on

Showing the 10 most notable of 47 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Metoprolol. Read the label on DailyMed › Jambolan’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Jambolan side to compare — that is a limit of the record, not a statement that Jambolan has no side effects.

How to take them

Some Metoprolol Products Have a Food Rule — Jambolan Should Not Break It

At least one FDA label for a product containing Metoprolol says to take it with food. If you take Jambolan on an empty stomach out of habit, keep them separate — and take Metoprolol with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Metoprolol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administer once daily with food or after a meal.

From the Dosage and Administration section of the FDA label we read for Metoprolol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Jambolan or Metoprolol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jambolan or Metoprolol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Metoprolol

This page covers Jambolan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metoprolol page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 152 moderate · 26 minor.

From our pharmacist’s overview on the Metoprolol page

“With metoprolol (Lopressor, Toprol XL), a beta-blocker for high blood pressure and heart problems, these interactions deserve genuine care, starting with the five rated major. Most entries pull blood pressure one way or the other: many supplements add to metoprolol's lowering effect and can drop pressure too far, while a few, tyramine…”

Reviewed by 2 · Jul 18, 2026

Open the Metoprolol interaction page

One more smart check

Taking Jambolan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 91 real supplement products containing Jambolan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jambolan. Even though Jambolan itself has no known interaction with Metoprolol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jambolan and Metoprolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jambolan
Top half

#405 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metoprolol
Top 10

#7 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jambolan reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Jambolan and Metoprolol records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jambolan

What is Jambolan?

  • Blood sugar support
  • Digestive upset and diarrhea
  • Sore throat and mouth health
  • Antimicrobial
  • General antioxidant support

Jambolan (Syzygium cumini), also called Java plum or black plum, is a tropical fruit tree traditionally used for blood sugar and digestive complaints. Human evidence for these uses is limited and not strong, so it should not replace proven treatments like diabetes medication. The fruit is safe as food, but talk to your pharmacist or doctor before using concentrated supplements.

Syzygium cumini · Myrtaceae · Seeds, fruit, leaves, and bark · Dried seed powder, capsules, tea, fruit extract, juice

An interaction check asks whether these two react with each other — it does not ask whether Jambolan is a good idea for someone in your situation. Here is what our Jambolan record says about it on its own.

Jambolan: dosing

There is no well-established standardized dose for Jambolan supplements. Traditional use and products vary widely in the part used (seed, fruit, leaf, or bark) and in how concentrated they are.Because a proven safe and effective dose has not been set, the best approach is to follow the directions on the product label and not exceed them.

From our Jambolan monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jambolan monograph & all interactions
Medication

About Metoprolol

What Is Metoprolol Used For?

Brand names: Lopressor, Toprol XL

Metoprolol is used to treat several heart and blood pressure conditions. Metoprolol succinate extended-release tablets (including Toprol-XL) are approved for high blood pressure, angina pectoris (chest pain from the heart), and heart failure. Metoprolol tartrate tablets (including Lopressor) are approved for high blood pressure, angina, and — when used alongside intravenous metoprolol — to reduce the risk of cardiovascular death after a definite or suspected heart attack.

Metoprolol tartrate injection (intravenous form) is used in hemodynamically stable patients with a definite or suspected acute heart attack to reduce cardiovascular death, and is followed by oral metoprolol therapy. Lowering blood pressure with metoprolol reduces the risk of strokes and heart attacks.

Most-Reported Side Effects for Metoprolol

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 23,416 reports
Dyspnea 20,183 reports
Diarrhea 19,912 reports
Nausea 19,659 reports
Dizziness 16,726 reports
See full Metoprolol drug information
Keep checking

Other Drugs & Jambolan

Browse every other medication we’ve checked against Jambolan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
186Moderate
0Minor
2,643No known interaction
186 Moderate 2,643 No interaction
Moderate

186 interactions

Showing 60 of 186 moderate interactions — see all 186 on the Jambolan page.

No interaction 2,643 drugs checked — show the list

We also checked Jambolan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,643 medications checked with no known interaction — see the full Jambolan list.

See the full Jambolan interactions page
See every supplement checked against Metoprolol, ranked by severity
Evidence & sources

Jambolan References

The 7 references that drive our Jambolan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Teixeira CC, Weinert LS, Barbosa DC, et al. Syzygium cumini (L.) Skeels in the treatment of type 2 diabetes. Diabetes Care 2004;27:3019-20.
  2. Sharma SB, Nasir A, Prabhu KM, et al. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 2003;85:201-6. PubMed
  3. Sridhar SB, Sheetal UD, Pai MR, Shastri MS. Preclinical evaluation of the antidiabetic effect of Eugenia jambolana seed powder in streptozotocin-diabetic rats. Braz J Med Biol Res 2005;38:463-8. PubMed
  4. Villasenor IM, Lamadrid MR. Comparative anti-hyperglycemic potentials of medicinal plants. J Ethnopharmacol 2006;104:129-31. PubMed
  5. Chinni S, Dubala A, Kosaraju J, et al. Effect of crude extract of Eugenia jambolana Lam. on human cytochrome P450 enzymes. Phytother Res 2014;28(11):1731-4. doi: 10.1002/ptr.5137.
  6. Vora A, Varghese A, Kachwala Y, et al. Eugenia jambolana extract reduces the systemic exposure of Sitagliptin and improves conditions associated with diabetes: A pharmacokinetic and a pharmacodynamic herb-drug interaction study. J Tradit Complement Med. 2 PubMed
  7. Araújo GR, Teles BSBS, Xoteslem GC, Gratieri T, Fortes RC, Novaes MR. Randomized, double-blind clinical trial comparing the healing of stasis ulcers in lower limbs with standard hydrocolloid gel dressings and with dressings with Syzygium cumini extract. P PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jambolan and Metoprolol Together: Common Questions

Is it safe to take Jambolan with Metoprolol?
We do not list a known interaction between Jambolan and Metoprolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Jambolan and Metoprolol at the same time of day?
At least one FDA label for a product containing Metoprolol says to take it with food. If you take Jambolan on an empty stomach out of habit, keep them separate and take Metoprolol with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Metoprolol products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Jambolan and Metoprolol combination checked?
Interactions in our licensed database are recorded against drug classes. Metoprolol is filed under 6 classifications, and Jambolan has documented interactions with 3 drug classes — none of Metoprolol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jambolan interact with any other medications?
Yes. Jambolan has 186 documented drug interactions in our database — Metoprolol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metoprolol interact with any supplements?
Yes. Metoprolol has documented interactions with 183 supplements in our database — Jambolan is not one of them. The Metoprolol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jambolan monograph Uses, safety profile, and every drug interaction in one place Metoprolol drug information The full plain-English guide to this medication Metoprolol supplement interactions Every supplement checked against Metoprolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metoprolol and Jambolan?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.