Drug & supplement interaction

Periwinkle + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide

Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide brand names: Rhinogesic JR, Rhinogesic.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Periwinkle and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Periwinkle and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide and Periwinkle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Periwinkle safety at a glance

Periwinkle overall Use caution Periwinkle contains strong alkaloids that can be toxic in higher doses, so it should be used carefully and only with professional advice.
Pregnancy Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide and Periwinkle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide is filed under 17 classifications — including cytochrome p450 2e1 (cyp2e1) substrates, glucuronidated drugs, cytochrome p450 2d6 (cyp2d6) inhibitors. Periwinkle has documented interactions with 1 drug class — the most serious being antihypertensive drugs (moderate) — and none of Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Periwinkle Does Interact With Other Medications

Periwinkle has 172 moderate known drug interactions in our database — Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide)
Taking anything else?

Check Another of Your Medications Against Periwinkle

Covers the 2,830 medications we’ve checked against Periwinkle. Pick one to open its full report.

What to actually watch for

What Periwinkle Itself Has Been Linked To

This is not an interaction — nothing below involves Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide. It is the side-effect record for Periwinkle on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Periwinkle, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “Periwinkle is generally regarded as unsafe for use. Orally, periwinkle can cause cytotoxic, neurologic, liver, and kidney damage due to its vinca alkaloid constituents (17). Periwinkle has also been reported to cause gastrointestinal complaints, skin flushing, and hypotension (18).”

    Periwinkle · Natural Medicines adverse-effect record, reported in hypotension.

    2 sources cited
    1. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Flushing Additional detail

    “Orally, periwinkle can cause skin flushing (18).”

    Periwinkle · Natural Medicines adverse-effect record, reported in niacin-induced flushing.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Low blood pressure Additional detail

    Recorded for Periwinkle in the same Natural Medicines adverse-effect record shown under Kidney problems above.

Everything above comes from the Natural Medicines adverse-effect record for Periwinkle — expand a row for the licensed statement it rests on. We haven’t matched Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide.

Special populations

Periwinkle in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide

This page covers Periwinkle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide page lists 292 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).

By severity: 14 major · 232 moderate · 46 minor.

From our pharmacist’s overview on the Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide page

“I would slow down before pairing supplements with Rhinogesic (acetaminophen, chlorpheniramine, phenylephrine, salicylamide). Each part of this cold remedy opens a different door to trouble, so supplements can collide with it from several directions at once.”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction page

One more smart check

Taking Periwinkle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38 real supplement products containing Periwinkle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Periwinkle. Even though Periwinkle itself has no known interaction with Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Periwinkle and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Periwinkle
Top half

#638 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide
Top 25%

#496 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Periwinkle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Periwinkle and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Periwinkle

What is Periwinkle?

  • Memory and cognitive support
  • Circulation problems
  • Dizziness and ringing in the ears
  • Minor wounds and sore throat (traditional)
  • High blood pressure (traditional)

Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circulation. Evidence in humans is limited and mixed, and the plant contains potent compounds that can be toxic in larger amounts, so it should be used only with professional guidance. A closely related plant, Madagascar periwinkle, is the source of important cancer chemotherapy drugs but is not safe to use as a home remedy.

Vinca minor · Apocynaceae · Aerial parts (leaves and flowering tops); related compounds come from Catharanthus roseus (Madagascar periwinkle) · Capsules, tablets, dried herb, tinctures, teas, and standardized extracts (such as vinpocetine derived from the plant's alkaloids)

An interaction check asks whether these two react with each other — it does not ask whether Periwinkle is a good idea for someone in your situation. Here is what our Periwinkle record says about it on its own.

Periwinkle: dosing

There is no well-established standard dose for periwinkle as an herb. Products vary widely in strength and in which part of the plant or which extract they contain.If you use a commercial product, follow the directions on the label and do not take more than recommended.

From our Periwinkle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Periwinkle monograph & all interactions
Keep checking

Other Drugs & Periwinkle

Browse every other medication we’ve checked against Periwinkle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Periwinkle page.

No interaction 2,657 drugs checked — show the list

We also checked Periwinkle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Periwinkle list.

See the full Periwinkle interactions page
See every supplement checked against Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide, ranked by severity
Evidence & sources

Periwinkle References

The 5 references that drive our Periwinkle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Periwinkle and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide Together: Common Questions

Is it safe to take Periwinkle with Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide?
We do not list a known interaction between Periwinkle and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Periwinkle and Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide combination checked?
Interactions in our licensed database are recorded against drug classes. Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide is filed under 17 classifications, and Periwinkle has documented interactions with 1 drug class — none of Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Periwinkle interact with any other medications?
Yes. Periwinkle has 172 documented drug interactions in our database — Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interact with any supplements?
Yes. Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide has documented interactions with 292 supplements in our database — Periwinkle is not one of them. The Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Periwinkle monograph Uses, safety profile, and every drug interaction in one place Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide supplement interactions Every supplement checked against Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide and Periwinkle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.