Capers Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Capers interacts with medications. The heart of this page is the interaction list — every drug Capers is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Capers is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Capers against your medication
Add one medicationCapers Drug Interactions: The Bottom Line
From the HelloPharmacist Editorial Team · Updated July 2026Based on the available evidence, the overall risk of a clinically significant Capers drug interaction appears low for most people, with the main caution applying to those who take blood sugar medicines. None of the listed interactions are rated major, and the concern behind them rests on limited and partly conflicting human research.
The interaction that deserves the most attention involves antidiabetes drugs. Some early human research found that a caper fruit extract lowered fasting blood sugar and HbA1c in people with type 2 diabetes who were already on these medicines, which could add to the medicines' effect. Other research did not find this, so the effect is not well established. Even so, an extra drop in blood sugar could matter for anyone whose glucose is closely managed, so it is worth being aware of.
Although dozens of medications appear on the list, nearly all of them trace back to this single possible effect on blood sugar rather than separate proven problems. Because the evidence is preliminary and inconsistent, most of these combinations have not been shown to cause meaningful changes in people.
Based on HelloPharmacist’s Capers interaction data and reviewed under our editorial standards.
Drugs that interact with Capers
86 medications have a known interaction with Capers, graded by severity. Select any drug for the full evidence-based detail.
Don’t want to scroll the list? Just ask.
Tell us the medications you take and we’ll check each one against Capers using our pharmacist-reviewed interaction data.
AI summaries are generated from our Capers interaction data for education only — always confirm with your pharmacist. How we use AI
No drugs match “”.
AcarboseGlucobay, Prandase, Precose
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Acarbose interaction Acarbose drug page: uses, dosage & side effectsAcetohexamideDymelor
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Acetohexamide interactionAlbiglutideTanzeum
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Albiglutide interactionAlogliptinNesina
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Alogliptin interaction Alogliptin drug page: uses, dosage & side effectsAlogliptin, MetforminKazano
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Alogliptin, Pioglitazone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Canagliflozin interaction Canagliflozin drug page: uses, dosage & side effectsCanagliflozin, MetforminInvokamet
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Chlorpropamide interactionDapagliflozinFarxiga
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Dapagliflozin interaction Dapagliflozin drug page: uses, dosage & side effectsDapagliflozin Propanediol, MetforminXigduo XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Dasiglucagon Hydrochloride interaction Dasiglucagon Hydrochloride drug page: uses, dosage & side effectsDulaglutideTrulicity
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Dulaglutide interaction Dulaglutide drug page: uses, dosage & side effectsEmpagliflozinJardiance
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Empagliflozin interaction Empagliflozin drug page: uses, dosage & side effectsEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Ertugliflozin interaction Ertugliflozin drug page: uses, dosage & side effectsErtugliflozin, Metformin HydrochlorideSegluromet
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Exenatide interaction Exenatide drug page: uses, dosage & side effectsExenatide SyntheticBydureon BCISE
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Exenatide Synthetic interaction Exenatide Synthetic drug page: uses, dosage & side effectsGliclazideDiamicron
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Gliclazide interactionGlimepirideAmaryl
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Glimepiride interaction Glimepiride drug page: uses, dosage & side effectsGlipizideGlucotrol, Glucotrol XL
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Glipizide interaction Glipizide drug page: uses, dosage & side effectsGlipizide, MetforminMetaglip
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Glucagon interaction Glucagon drug page: uses, dosage & side effectsGlucoseIV Glucose
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Glyburide interaction Glyburide drug page: uses, dosage & side effectsGlyburide, MetforminGlucovance
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Glyburide, Metformin interactionInhaled InsulinExubera
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Inhaled Insulin interactionInsulinNovoRapid Insulin
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin interactionInsulin (bovine)Hypurin Bovine Neutral
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin (bovine) interactionInsulin (human)Afrezza, Novolin 70/30, Novolin L, Novolin N, Novolin R
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin (human) interaction Insulin (human) drug page: uses, dosage & side effectsInsulin (pork)Hypurin Porcine Neutral, Lente Iletin II, NPH Iletin, NPH Iletin II, Pork Actrapid, Regular Iletin +1 more
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin (pork) interactionInsulin (rdna)Actrapid, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L +8 more
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin (rdna) interaction Insulin (rdna) drug page: uses, dosage & side effectsInsulin AspartFiasp
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Aspart interaction Insulin Aspart drug page: uses, dosage & side effectsInsulin Aspart, Insulin DegludecRyzodeg 70/30
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Aspart, Insulin Degludec interactionInsulin DegludecTresiba
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Degludec interaction Insulin Degludec drug page: uses, dosage & side effectsInsulin Degludec, LiraglutideXultophy 100/3.6
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Degludec, Liraglutide interactionInsulin GlargineBasaglar, Lusduna, Semglee
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Glargine interaction Insulin Glargine drug page: uses, dosage & side effectsInsulin Glargine (rdna)Lantus
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Glargine (rdna) interaction Insulin Glargine (rdna) drug page: uses, dosage & side effectsInsulin Glargine RecombinantToujeo Solostar
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Glargine Recombinant interactionInsulin Glargine, LixisenatideSoliqua 100/33
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Glargine, Lixisenatide interactionInsulin Glulisine (rdna)Apidra
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Glulisine (rdna) interaction Insulin Glulisine (rdna) drug page: uses, dosage & side effectsInsulin Human, Sodium ChlorideMyxredlin
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Human, Sodium Chloride interaction Insulin Human, Sodium Chloride drug page: uses, dosage & side effectsInsulin LisproAdmelog, Admelog Solostar
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Lispro interaction Insulin Lispro drug page: uses, dosage & side effectsInsulin Lispro RecombinantHumalog Kwikpen
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Lispro Recombinant interactionInsulin Lispro-aabcLyumjev
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Lispro-aabc interactionInsulin DetermirLevemir
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Insulin Determir interaction Insulin Determir drug page: uses, dosage & side effectsLinagliptinTradjenta
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Linagliptin interaction Linagliptin drug page: uses, dosage & side effectsLinagliptin, Metformin HydrochlorideJentadueto XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Linagliptin, Metformin Hydrochloride interactionLiraglutideVictoza
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Liraglutide interaction Liraglutide drug page: uses, dosage & side effectsLiraglutide RecombinantSaxenda
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Liraglutide Recombinant interaction Liraglutide Recombinant drug page: uses, dosage & side effectsLixisenatideAdlyxin
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Lixisenatide interaction Lixisenatide drug page: uses, dosage & side effectsMetforminGlucophage, Metformin
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Metformin interaction Metformin drug page: uses, dosage & side effectsMetformin HydrochlorideRiomet ER
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Metformin Hydrochloride interactionMetformin XrGlucophage XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Metformin Xr interactionMetformin, LinagliptinJentadueto
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Metformin, Sitagliptin interactionMiglitolGlyset
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Miglitol interaction Miglitol drug page: uses, dosage & side effectsMuraglitazarPargluva
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Muraglitazar interactionNateglinideStarlix
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Nateglinide interaction Nateglinide drug page: uses, dosage & side effectsPioglitazoneActos
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Pioglitazone interaction Pioglitazone drug page: uses, dosage & side effectsPramlintideSymlin
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Pramlintide interaction Pramlintide drug page: uses, dosage & side effectsRepaglinideGlucoNorm, Prandin
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Repaglinide interaction Repaglinide drug page: uses, dosage & side effectsRosiglitazone MaleateAvandia
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Rosiglitazone Maleate interaction Rosiglitazone Maleate drug page: uses, dosage & side effectsSaxagliptinOnglyza
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Saxagliptin interaction Saxagliptin drug page: uses, dosage & side effectsSaxagliptin, Metformin XrKombiglyze
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Saxagliptin, Metformin Xr interactionSemaglutideOzempic, Rybelsus, Wegovy
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Semaglutide interaction Semaglutide drug page: uses, dosage & side effectsSimvastatin, SitagliptinJuvisync
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Simvastatin, Sitagliptin interactionSitagliptinJanuvia, Zituvio
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Sitagliptin interaction Sitagliptin drug page: uses, dosage & side effectsSitagliptin, MetforminZituvimet
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Sitagliptin, Metformin interactionSotagliflozinInpefa
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Sotagliflozin interactionTirzepatideMounjaro, Zepbound
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Tirzepatide interaction Tirzepatide drug page: uses, dosage & side effectsTobutamideMobenol
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Tobutamide interactionTolazamideTolinase
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Tolazamide interaction Tolazamide drug page: uses, dosage & side effectsTolbutamideOrinase
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Tolbutamide interaction Tolbutamide drug page: uses, dosage & side effectsTroglitazoneRezulin
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Troglitazone interactionVildagliptinGalvus
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Vildagliptin interactionPioglitazone, MetforminActoPlus Met
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Pioglitazone, Metformin interactionRosiglitazone, GlimepirideAvandaryl
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs.
Read the full Capers + Rosiglitazone, Glimepiride interactionWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Capers combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The kinds of drugs Capers affects
Every type of medication (drug category) Capers is known to interact with. Open any category for the detail — or search your exact drug in the checker above.
Antidiabetes Drugs
Some preliminary clinical research shows that taking caper fruit extract 1200 mg daily for 2 months can lower fasting blood glucose and glycated hemoglobin (HbA1c) in patients with type 2 diabetes who are already taking antidiabetes drugs. However, other research does not support this effect. Until more is known, monitor blood glucose levels closely. Medication dose adjustments may be necessary.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Capers: Uses, Safety & Side Effects
Capers are the edible pickled flower buds of the Capparis spinosa shrub, used widely as food and in traditional medicine. They contain antioxidant plant compounds, but high-quality human studies on health benefits are limited, so the supplement claims remain largely unproven. As a food, capers are generally safe, but talk to your pharmacist or doctor before using concentrated extracts.
- Scientific name
- Capparis spinosa
- Family
- Capparaceae
- Part used
- Flower buds, fruit, root bark, and leaves
- Common forms
- Pickled or brined buds (food), capsules, extracts, dried powder
- Digestive support
- Antioxidant source
- Blood sugar support
- Anti-inflammatory
- Skin and traditional tonic uses
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe as a food, but concentrated supplements are not well studied.
There is insufficient reliable information available about the safety of capers used in medicinal amounts during pregnancy and lactation; avoid using.
Read the full pregnancy detailThere is insufficient reliable information available about the safety of capers used in medicinal amounts during pregnancy and lactation; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Capers are the small, green flower buds of Capparis spinosa, a low, spiny shrub that grows in dry, rocky areas around the Mediterranean and parts of Asia. The buds are usually picked before they bloom and then pickled in salt or brine, which gives them their tangy, salty flavor.
Most people know capers as a food used in sauces, salads, and seafood dishes. The plant also has a long history in traditional medicine, where the buds, fruit, root bark, and leaves were used for digestion, joint discomfort, and general wellness. Today, capers are sometimes sold as extracts or capsules marketed for their antioxidant content.
How it works
Capers contain several plant compounds that may explain their proposed effects. These include flavonoids such as rutin and quercetin, along with other antioxidant substances that may help protect cells from damage caused by unstable molecules called free radicals.
Laboratory studies suggest these compounds may have anti-inflammatory and antioxidant actions. Some researchers have also explored possible effects on blood sugar and fat metabolism. It is important to remember that most of this evidence comes from test-tube and animal research, and the effects in people may be much weaker or different.
Does Capers work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Capers, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Diabetes
Preliminary clinical research shows that taking caper fruit extract 400 mg three times daily for 2 months reduces fasting blood glucose by 20 mg/dL and improves glycated hemoglobin (HbA1c) by 0.4% when compared to baseline in patients with type 2 diabetes who are already taking antidiabetes drugs. These improvements were significant when compared with the placebo group. Patients taking caper fruit extract also showed improvements in triglyceride levels but not cholesterol levels. However, preliminary clinical research in adults with inadequately controlled type 2 diabetes and metabolic syndrome shows that taking caper fruit extract in a solution of grape vinegar and lactulose for 3 months does not reduce fasting blood glucose, HbA1c, or plasma lipid levels. However, it modestly decreases body weight and body mass index (BMI) when compared to control.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food, capers are generally considered safe for most people when eaten in normal amounts. Because they are usually packed in salt or brine, they can be high in sodium, which matters for people watching their salt intake, such as those with high blood pressure or heart problems.
Concentrated supplements and extracts are not well studied, so their safety is less certain. People with allergies to the plant should avoid it. Pregnant and breastfeeding women should stick to normal food amounts and avoid medicinal or concentrated doses, since there is not enough safety information. Always check with your pharmacist or doctor before starting any new supplement.
Side effects
Eating capers as food rarely causes problems for most people. The main concern is their high salt content, which may contribute to bloating, thirst, or higher blood pressure if eaten in large amounts.
Some people may have an allergic reaction, with symptoms like itching, rash, or swelling. Concentrated extracts could cause digestive upset, but side effects from supplements are not well documented. Stop using and seek medical care if you notice signs of a serious allergic reaction.
Capers: Reported Adverse Effects
Documented safety reports on Capers from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, capers seem to be well tolerated. No adverse effects have been reported in clinical research; however, a high-quality assessment of safety has not been conducted. Topically, capers can cause contact dermatitis.
- Huseini HF, Hasani-Rnjbar S, Nayebi N, et al. Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2013;21(5):447-52.
- Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.
Dermatitis Dermatologic
Topically, capers can cause contact dermatitis.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established standard dose for capers as a supplement. As a food, people simply use them as a flavoring in small amounts.
For capsules or extracts, follow the directions on the product label, since strengths vary widely between brands. Because reliable dosing information is lacking, it is best to talk with your pharmacist or doctor before using caper supplements, especially if you have any health conditions or take other medicines.
Capers & Pregnancy
Capers & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Capers monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Angelini G, Vena GA, Filotico R, et al. Allergic contact dermatitis from Capparis spinosa L. applied as wet compresses. Contact Dermatitis 1991;24:382-3.
- Huseini HF, Hasani-Rnjbar S, Nayebi N, et al. Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2013;21(5):447-52. PubMed
- Vahid H, Bonakdaran S, Khorasani ZM, et al. Effect of Capparis spinosa extract on metabolic parameters in patients with type-2 diabetes: A randomized controlled trial. Endocr Metab Immune Disord Drug Targets. 2019;19(1):100-107. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Capers
5 brands in our database make a supplement containing Capers.
Supplement products with Capers
53 products in our database contain Capers. Open any to see its full ingredient list and every drug interaction we check.
Capers: Common Questions
What is Capers used for, and does it work?
Does Capers interact with prescription medications?
How are Capers interactions rated?
Is it safe to take Capers with my medications?
Where does this Capers interaction information come from?
What are Capers used for?
Are Capers good for you?
Are Capers safe during pregnancy?
Can Capers cause side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Capers
A rotating sample of real supplements in our database that list Capers — open any to see its full ingredients and every drug interaction we check.
- StressCare by Himalaya
- Super Mushroom by Natural Factors Whole Earth & Sea
- Pure Food Men's 50+ by Natural Factors Whole Earth & Sea
- Big Friends Chewable Multi-Vitamin & Minerals Jungle Berry by Natural Factors
- StressCare by Himalaya
- Pure Food Men's Multivitiamn & Mineral by Natural Factors Whole Earth & Sea
- LiverCare by Himalaya
- Pure Food Men's Multivitamin & Mineral by Natural Factors Whole Earth & Sea
- LiverCare by Himalaya
- Pure Food Men's 50+ Multivitamin & Mineral by Natural Factors Whole Earth & Sea
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