Herb & supplement monograph

Feverfew Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Feverfew interacts with medications. The heart of this page is the interaction list — every drug Feverfew is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Feverfew is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

Feverfew Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Feverfew drug interaction appears low for most people, because nearly all listed interactions are theoretical. None of the interactions are rated major, and although all are graded moderate, they rest almost entirely on laboratory findings that have not been confirmed in humans.

Interactions deserving the most attention

The combination most worth watching is feverfew with anticoagulant or antiplatelet drugs, often called blood thinners. Lab research suggests feverfew may make platelets less sticky, and one person taking a high daily dose for several months had abnormal vaginal bleeding. That is limited evidence, but bleeding risk is the kind of effect where even a small added push can matter, so anyone on these medicines should be more careful with feverfew than the average person.

What the rest of the list means

The long list of interacting medications looks alarming, but almost all of it comes from a single idea: lab studies suggest feverfew might slow several enzymes the body uses to clear many common drugs. None of these enzyme effects has actually been reported to cause problems in people, so most combinations are flagged out of caution rather than proven harm.

Check your medications against Feverfew

Based on HelloPharmacist’s Feverfew interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Feverfew

929 medications have a known interaction with Feverfew, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Feverfew using our pharmacist-reviewed interaction data.

AI summaries are generated from our Feverfew interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Feverfew combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Feverfew affects

Every type of medication (drug category) Feverfew is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 7 drug categories Feverfew interacts with

Anticoagulant/antiplatelet DrugsCytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2c8 (cyp2c8) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 2d6 (cyp2d6) SubstratesCytochrome P450 3a4 (cyp3a4) Substrates

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).