Herb & supplement monograph

Job's Tears Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Job's Tears interacts with medications. The heart of this page is the interaction list — every drug Job's Tears is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Job's Tears is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Reviewed by licensed pharmacists Sourced from Natural Medicines

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Job's Tears Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Job's Tears drug interaction appears low for most people, since no interaction is rated major and none has been confirmed in human studies. Every listed interaction is rated moderate, and the documentation for each comes from animal or early lab research rather than well-controlled human trials.

Interactions deserving the most attention

The combinations worth the most attention involve medicines where small changes matter. Animal research suggests Job's Tears may help the gut absorb more of certain drugs, raising their blood levels; this could be meaningful for theophylline, which has a narrow safety margin, and for diltiazem, a blood pressure medicine. Early evidence also hints that Job's Tears may lower blood sugar, so people taking diabetes medications such as insulin or glyburide should watch for signs of low blood sugar.

What the rest of the list means

A long list of interacting medications can look worrying, but here it mostly reflects one broad theoretical concern applied to many drugs at once. These predictions come from animal and preliminary studies, and none of the effects has been shown to cause meaningful problems in people so far.

Check your medications against Job's Tears

Based on HelloPharmacist’s Job's Tears interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Job's Tears

128 medications have a known interaction with Job's Tears, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Job's Tears using our pharmacist-reviewed interaction data.

AI summaries are generated from our Job's Tears interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Job's Tears combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Job's Tears affects

Every type of medication (drug category) Job's Tears is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Job's Tears interacts with

Antidiabetes DrugsChlorzoxazone (parafon Forte, Paraflex)Dextromethorphan (robitussin Dm, Others)Diltiazem (cardizem, Others)Theophylline

Antidiabetes Drugs

Preliminary evidence shows that constituents of Job's tears might have hypoglycemic effects. Theoretically, concomitant use with drugs that decrease blood glucose levels might increase the risk of hypoglycemia. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.