Medication interaction hub

What Supplements Interact with Colchicine, Probenecid?

Colchicine, Probenecid brand name: ColBenemid. Every interaction below applies to the brands too.

156 Interactions 6 Major 111 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Colchicine, Probenecid? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Colchicine, Probenecid against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People take ColBenemid, the colchicine and probenecid combination, for stubborn gout, and this is one supplement list that deserves real wariness. Colchicine sits in a narrow window where small rises in blood level can turn treatment into poisoning, and most of the ingredients here, 121 acting on the CYP3A4 enzyme and 37 on the P-glycoprotein pump that clear it, can nudge that level up or down. Grapefruit alone, a major-rated entry, can push colchicine to unsafe levels, and autumn crocus is worse, since it literally contains colchicine.

Six of the 156 entries rate major, with 111 moderate and 39 minor, and the majors deserve your attention first. Beyond the level-changers, a few herbs stress the kidneys that clear both drugs, activated charcoal can block an oral dose from absorbing, and high-dose niacin can undercut probenecid's ability to flush out uric acid, its main job.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 111 Minor 39 No known interaction 1,296

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Colchicine, Probenecid: Top Interactions at a Glance

The Colchicine, Probenecid supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 156 interacting ingredients — plus 1,296 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Colchicine, Probenecid Combinations Today

The Colchicine, Probenecid + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Cannabis + Colchicine, Probenecidi

Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Inosine + Colchicine, Probenecidi

Inosine might reduce the effects of antigout medications.

Read the full interaction Moderate Likelihood Possible Strawberry + Colchicine, Probenecidi

In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Read the full interaction Moderate Likelihood Possible Feverfew + Colchicine, Probenecidi

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Bacopa + Colchicine, Probenecidi

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Quercetin + Colchicine, Probenecidi

Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Colchicine, Probenecid

All 1,452 ingredients in our database, ranked by severity — 156 with a Colchicine, Probenecid interaction on file and 1,296 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Colchicine, Probenecid?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cannabis with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Colchicine, Probenecid answer

Can you take Inosine with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Inosine might reduce the effects of antigout medications.

Full Inosine + Colchicine, Probenecid answer

Can you take Strawberry with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Colchicine, Probenecid answer

Can you take Feverfew with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Colchicine, Probenecid answer

Can you take Bacopa with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Colchicine, Probenecid answer

Can you take Echinacea with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Colchicine, Probenecid answer

Can you take Eleuthero with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of P-glycoprotein substrates.

Full Eleuthero + Colchicine, Probenecid answer

Can you take Eucalyptus with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Colchicine, Probenecid answer

Can you take European Barberry with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Colchicine, Probenecid answer

Can you take Evodia with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Colchicine, Probenecid answer

Can you take False Unicorn with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Colchicine, Probenecid answer

Can you take Fennel with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Colchicine, Probenecid answer

Can you take Fo-ti with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Colchicine, Probenecid answer

Can you take Garlic with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Colchicine, Probenecid answer

Can you take German Chamomile with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Colchicine, Probenecid answer

Can you take Ginger with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Colchicine, Probenecid answer

Can you take Ginkgo with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Colchicine, Probenecid answer

Can you take Goji with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Colchicine, Probenecid answer

Can you take Goldthread with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Colchicine, Probenecid answer

Can you take Grape with Colchicine, Probenecid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Colchicine, Probenecid answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Colchicine, Probenecid is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Colchicine, Probenecid, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Colchicine, Probenecid sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

Colchicine 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

Probenecid (Benemid) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Colchicine, Probenecid through this category.

Antigout Drugs 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Colchicine, Probenecid through this category.

Related: does Colchicine, Probenecid deplete any nutrients?

Colchicine, Probenecid has 3 reported nutrient associations in the research literature — see the Colchicine, Probenecid nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Colchicine, Probenecid

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Colchicine, Probenecid.

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Pharmacist Counseling Corner

Colchicine, Probenecid & Supplements: Common Questions

What supplements interact with Colchicine, Probenecid?
In our interaction database, 156 supplement and herbal ingredients have an interaction with Colchicine, Probenecid on file — 6 rated major, 111 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Colchicine, Probenecid supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Autumn Crocus and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Colchicine, Probenecid?
That depends entirely on which supplement. The honest answer for Colchicine, Probenecid is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like ColBenemid have the same supplement interactions as Colchicine, Probenecid?
Yes — ColBenemid all contain Colchicine, Probenecid, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Colchicine, Probenecid deplete any vitamins or nutrients?
It might — Colchicine, Probenecid has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Colchicine, Probenecid nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Colchicine, Probenecid and my other medications?
This page covers Colchicine, Probenecid against supplements and herbal ingredients. Checking Colchicine, Probenecid against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.