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Dietary supplement

Bacopa Extract 450 mg Ingredients & Drug Interactions

by NOW

Bacopa Extract 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bacopa Extract 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bacopa Extract 450 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, adhd symptoms.Based on those ingredients, 932 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacopa extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bacopa Extract 450 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Bacopa Extract 450 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bacopa Extract 450 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bacopa extract, 450 mg per capsule. Bacopa is a plant used in traditional medicine, and the extract concentrates its active compounds.

The capsule itself is made from hypromellose (a plant-derived coating), microcrystalline cellulose, silicon dioxide, and stearic acid — these are inactive ingredients that help hold the capsule together and keep it stable on the shelf.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bacopa's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: brain health and cognitive support.
  • We looked for evidence on: Cognitive function, Cognitive impairment, Attention deficit-hyperactivity disorder (ADHD), Alzheimer disease, Parkinson disease, memory — and 2 related terms.
  • The closest evidence on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Bacopa is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Cognitive impairment, Parkinson disease.

The evidence we hold on bacopa extract for cognitive function, memory, attention, sexual dysfunction, back pain, and Alzheimer disease is insufficient to rate. That means studies either haven't been done, the research is limited, or results are mixed — we can't say whether it works for these uses based on the data we have.

If cognitive or memory support is what you're considering bacopa for, talk with your doctor about what the current evidence shows and whether it's right for you.

The evidence, ingredient by ingredient Bacopa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacopa is generally well tolerated in studies, though long-term safety data are limited. The most common side effects are abdominal cramps, diarrhea, dry mouth, headache, and nausea.

Gastrointestinal side effects (bloating, cramps, diarrhea, indigestion, and others) occur in roughly 12 to 30 percent of people who take it. Some people also report drowsiness, insomnia, or vivid dreams.

There isn't enough safety data to recommend bacopa during pregnancy or while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking it — they can help you weigh what you know about this product against your individual situation.

Side effects, ingredient by ingredient Bacopa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacopa.
  • The most serious interaction on file is rated Moderate.
  • For scale: 933 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any drugs metabolized by CYP1A2, CYP2C9, CYP2C19, or CYP3A4 enzymes — a broad category that includes many heart, blood pressure, seizure, and immunosuppressant medications. Also check if you use anticholinergic drugs, cholinergic drugs, cevimeline (Evoxac), or thyroid hormone.

The medication search tool on this page can help you verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Bacopa extract is generally well tolerated but has documented interactions with many medications, especially those your liver breaks down. If you take any prescription drugs — particularly for heart rhythm, blood thinners, seizures, Sjogren syndrome, or thyroid conditions — check with your doctor or pharmacist before starting.

Pregnancy and breastfeeding safety data are limited, so discuss it with your healthcare provider if either applies to you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bacopa Extract 450 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739045881
Net contents 90 Veg Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 245140
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bacopa Extract 450 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
UPC/BARCODE
733739045881
IngredientAmount% DV
Bacopa extract450 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 capsule daily.

Formula

Bacopa monnieri has been used by Ayurvedic herbalists for centuries. Recent scientific studies indicate that bacopa can support nervous system health by supporting the brain’s free radical protective systems.

Traditional ayurvedic herb standardized to 40% Bacosides

Precautions

Caution: For adults only. Bacopa may cause gastrointestinal discomfort in sensitive individuals.

Consult physician if pregnant/nursing, taking medication (especially MAO inhibitors, cholinergic and anti-cholinergic medications, acetylcholinesterase inhibitors, or thyroid hormones), or have a medical condition (especially hyperthyroidism).

Keep out of reach of children.

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that process other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Promotes brain health

Non-GMO

Vegetarian/vegan

Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

FDA Statement of Identity

A Dietary Supplement

General Statements

Botanicals/herbs Family owned since 1968.

Storage

Store in a cool, dry place after opening.

Seals/Symbols

GMP Quality Assured

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bacopa Extract 450 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bacopa Extract 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bacopa Extract 450 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Amounts shown are per serving.

Bacopa extract

Interacts with
932 drugs
450 mg per serving Form: Bacosides

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for s...

Bacopa extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bacopa Extract 450 mg by NOW Drug Interactions

Want to check YOUR meds against Bacopa Extract 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
932Drugs
919 Moderate 13 Minor

Ingredients driving the most interactions

Bacopa extract 932

Individual Drug Interactions

The ingredients in Bacopa Extract 450 mg interact with 932 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bacopa Extract 450 mg interact with drugs. Each result below shows which ingredient is responsible. Bacopa extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bacopa Extract 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacopa extract8 drug types · 932 drugs

Anticholinergic Drugs

Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.

Likelihood Possible Evidence D
Cevimeline (Evoxac)

Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.

Likelihood Possible Evidence D
Bacopa extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bacopa Extract 450 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Bacopa Extract 450 mg by NOW: Common Questions

Does Bacopa Extract 450 mg by NOW interact with any medications?
Yes. Based on its ingredients, Bacopa Extract 450 mg has a known interaction with 932 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bacopa Extract 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects?
The most frequent side effects are abdominal cramps, diarrhea, dry mouth, headache, and nausea. Between 12 and 30 percent of people in studies reported gastrointestinal side effects like bloating, indigestion, or decreased appetite. Some people also experience drowsiness, insomnia, or vivid dreams.
Can I take bacopa if I'm pregnant or breastfeeding?
There isn't enough safety information to recommend bacopa during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about your individual situation — they can help you decide whether it's appropriate for you.
How well does bacopa work for memory or focus?
The evidence we have for bacopa extract's effectiveness on cognitive function, memory, ADHD, or Alzheimer disease is insufficient to rate. Studies are limited or results are mixed, so we can't say whether it works for these purposes based on the data available.
Is bacopa safe to take long-term?
Bacopa is generally well tolerated in studies, but long-term safety data are limited. If you're thinking about taking it for an extended period, discuss it with your doctor or pharmacist — they can monitor you for side effects and any changes.
What is bacopa extract?
Bacopa is a plant used in traditional medicine. This product is an extract — a concentrated form of the plant's active compounds — at 450 mg per capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bacopa Extract 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bacopa Extract 450 mg label
Go deeper

The Full Monographs Behind Bacopa Extract 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacopa

Interacts with 932 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph →
Sources

Sources & How We Checked

Bacopa Extract 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacopa 12 references
  1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
  2. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
  3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
  4. Kar, A., Panda, S., and Bharti, S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002;81(2):281-285. PubMed
  5. Mukherjee, G. D. and Dey, C. D. Clinical trial on Brahmi. I. J.Exp.Med.Sci. 1966;10(1):5-11.
  6. Kar A, Pandit S, Mukherjee K, Bahadur S, Mukherjee PK. Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study. J Sci Food Agric 2017;97(1):333-40. doi: 10.1002/jsfa.7739. PubMed
  7. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151(1):528-35. PubMed
  8. Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules 2014;19(2):2588-601. PubMed
  9. Prabhakar S, Vishnu VY, Modi M, et al. Efficacy of Bacopa monnieri (Brahmi) and donepezil in Alzheimer's disease and mild cognitive impairment: a randomized double-blind parallel phase 2b study. Ann Indian Acad Neurol 2020;23(6):767-73. PubMed
  10. Acquarulo B, Tandon P, Macica CM. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. J Med Case Rep 2022;16(1):253. PubMed
  11. Keegan AP, Stough C, Paris D, et al. Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor levels but beneficially modulates nuclear factor kappa B and cyclic AMP response element-binding protein levels in healthy elderl
  12. Yaworski AM, Blyumin M, Chang T, Mammen AL, Greene M. Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa. Muscle Nerve 2023;67(2):E1-E3.

See these in context on the Bacopa monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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