Major interaction on record — check this product against your medications before combining. Based on 5 of 19 ingredients. Check your meds →
Dietary supplement

Cardio Cuts Black Cherry Ingredients & Drug Interactions

by NDS

Cardio Cuts Black Cherry label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cardio Cuts Black Cherry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Cardio Cuts Black Cherry is a dietary supplement by NDS with 19 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 1,678 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin D, Magnesium, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cardio Cuts Black Cherry by NDS

Ask about any prescription or over-the-counter medication and we check it for interactions with Cardio Cuts Black Cherry by NDS — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Cardio Cuts Black Cherry by NDS

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 12 of its 48 active ingredients.
  • “THYRO-LEAN COMPLEX” is a proprietary blend — the label gives one combined amount (2,870 mg) without saying how much of each component you get.
  • “Tone Tight Blend” is a proprietary blend — the label gives one combined amount (2,220 mg) without saying how much of each component you get.
  • “Carnitine Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

Cardio Cuts Black Cherry contains 48 ingredients in total. The active amino acids include L-Glutamine, L-Leucine, L-Isoleucine, L-Valine, L-Arginine, L-Tyrosine, and L-Histidine Hydrochloride, which support muscle recovery and protein synthesis.

You'll also find Taurine and L-Carnitine, both involved in heart and muscle energy production. The formula includes B vitamins—Vitamin B6 and Vitamin B12 for energy and nerve function—along with Folic Acid and Folate (though we hold no data for the Folate ingredient).

Alpha-Lipoic Acid is an antioxidant, while Beta-alanine (CarnoSyn brand) supports athletic performance. Other notable actives are Ribose (a sugar that fuels muscle cells), Vitamin D (for bone and immune health), Glycerol (which may help hydration), Vinpocetine (a circulation aid), Phosphatidylserine (for brain function), Raspberry Ketones, and Kelp (a seaweed concentrate).

The remaining ingredients are inactive fillers and flavorings, including malic acid, maltodextrin, sucralose, and food colorings.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pre-workout energy and cardiovascular performance support.
  • We looked for evidence on: Athletic endurance, Workout performance, Cardiovascular health.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glycerol is rated "Possibly Effective" for Athletic performance.
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance, Physical performance.

The evidence for effectiveness varies widely across this product's ingredients. Vitamin B6 and Vitamin B12 are both effective for their respective vitamin deficiencies and have other established uses.

Folic Acid is effective for folate deficiency and neural tube birth defect prevention. L-Carnitine is effective for L-carnitine deficiency and possibly effective for heart failure and high cholesterol.

Vitamin D is effective for bone-related disorders like rickets and osteomalacia. Several ingredients show only possibly effective or insufficient evidence: L-Arginine has no established effectiveness rating in our data, Alpha-Lipoic Acid is possibly effective for diabetic nerve pain and cholesterol, Ribose is possibly ineffective for athletic performance and heart failure, Taurine is possibly effective for hepatitis and heart failure, L-Tyrosine is possibly effective for cognitive function, Vinpocetine is possibly effective for dementia, Beta-alanine is possibly effective for athletic performance, and Phosphatidylserine is possibly effective for age-related cognitive decline.

Glycerol is likely effective for constipation but likely ineffective for stroke. Kelp, Raspberry Ketones, Histidine, and Tartaric Acid all have insufficient evidence or have not been rated for their intended uses in this formula.

The evidence, ingredient by ingredient Vitamin B6 Vitamin D Vitamin B12 Magnesium Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 28 of the 31 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 31 of 31.
  • General safety write-ups exist for 31 of 31.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses, but several carry cautions. Vitamin B6 is safe at normal amounts but high doses over time can damage nerves (sensory neuropathy).

Folic Acid and Vitamin B12 are both considered safe at recommended doses, including during pregnancy and breastfeeding. L-Glutamine is generally well tolerated but should be used under medical supervision in people with kidney or liver disease; common side effects include bloating, constipation, and nausea.

Alpha-Lipoic Acid is generally well tolerated but should be avoided in pregnancy and breastfeeding due to insufficient safety data. Ribose can lower blood sugar and should be avoided in pregnancy and breastfeeding.

L-Arginine is generally well tolerated short-term but can lower blood pressure and should only be used under medical guidance; it may trigger airway inflammation in people with asthma. Taurine is generally well tolerated short-term, though long-term safety is unclear.

L-Tyrosine and L-Carnitine are generally well tolerated, though L-Carnitine at high doses may cause a fish-like body odor and stomach upset. Vitamin D is safe at recommended doses but very high doses over time can cause toxicity with symptoms of high blood calcium.

Vinpocetine should be avoided in pregnancy. Raspberry Ketone and Kelp lack sufficient safety data and should be avoided in pregnancy and breastfeeding; Kelp's high iodine content can disrupt thyroid function.

Side effects, ingredient by ingredient Vitamin B6 Vitamin D Vitamin B12 Magnesium Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 27 of the 31 matched ingredients can interact with medications — Vinpocetine, Grape, Fucus Vesiculosus, Alpha-lipoic Acid, Calcium, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,677 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you're on anticonvulsant medications (seizure drugs like phenytoin or phenobarbital), antihypertensive drugs (blood pressure medications), blood thinners or antiplatelet drugs (including warfarin), chemotherapy agents, thyroid hormone replacement, calcium channel blockers or other heart medications, potassium-sparing diuretics, diabetes medications, ACE inhibitors or ARBs, lithium, or methotrexate. These represent the drug categories with the most serious documented interactions across the product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a complex multi-ingredient sports and energy formula that interacts with a substantial number of medications, especially blood pressure drugs, seizure medications, blood thinners, heart medications, and diabetes drugs. If you take any prescription medication—particularly for blood pressure, seizures, blood thinning, heart rhythm, diabetes, or thyroid conditions—you need to check your exact drugs against the interaction tool on this page before you start.

Talk to your pharmacist before taking this product alongside any regular medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 38 of 48 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cardio Cuts Black Cherry, straight from the product label.

Brand NDS
Barcode (UPC) 811020901501
Net contents 8.5 oz.; 242 Gram(s)
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 36155
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cardio Cuts Black Cherry by NDS, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Gram(s)
Maximum serving Sizes:
12 Gram(s)
Servings per container
20
UPC/BARCODE
811020901501
IngredientAmount% DV
Calories20 {Calories}--
Total Carbohydrates2 Gram(s)1%
L-Glutamine0 NP--
Sugar1 Gram(s)--
Total Fat1.5 Gram(s)2%
Vitamin B610 mg500%
Folic Acid0 NP--
Alpha Lipoic Acid100 mg--
L-Leucine0 NP--
Bioenergy Ribose0 NP--
L-Arginine0 NP--
L-Isoleucine0 NP--
Taurine0 NP--
L-Tyrosine0 NP--
L-Valine0 NP--
Glycerol0 NP--
L-Histidine Hydrochloride0 NP--
Tartaric Acid0 NP--
L-Carnitine0 NP--
Vitamin D800 IU200%
Raspberry Ketones100 mg--
Kelp0 NP--
Vitamin D0 NP--
Vitamin B1260 mcg1000%
Folate400 mcg100%
CarnoSyn1000 mg--
Vinpocetine0 NP--
Pyridoxine Hydrochloride0 NP--
Phosphatidyl Serine0 NP--
N-Acetyl Cysteine0 NP--
N-Acetyl-L-Carnitine HCl0 NP--
Calcium Citrate0 NP--
Methylcobalamin0 NP--
Magnesium Aspartate0 NP--
Magnesium50 mg13%
Medium Chain Triglyceride powder1000 mg--
L-Glutamine AKG0 NP--
Co-enzyme Q100 NP--
Norvaline0 NP--
Calcium200 mg20%
CARDIO CUTS(R) CROSS/OVER BLEND8061 mg--
THYRO-LEAN COMPLEX2870 mg--
Tone Tight Blend2220 mg--
Conjugated Linoleic Acid, Powder1000 mg--
Carnitine Complex0 NP--
Thyro-Support Blend650 mg--
Gum Guggul0 NP--
LEAN-PUMP RECOVERY COMPLEX3423 mg--
Endu-Recover Blend2423 mg--
Bis Picolinato Oxo Vanadium0 NP--
Vaso-Lean Blend1000 mg--
L-Arginine AKG 2:10 NP--
L-Arginine Ethyl Ester0 NP--
THERMO-OUTPUT COMPLEX1108 mg--
Rejuvenation Blend670 mg--
Polygonum cuspidatum0 NP--
Grape seed ext0 NP--
Pine bark ext0 NP--
Thermo-Cardio Blend438 mg--
Caffeine0 NP--
Amla (Phyllanthus emblica) (fruit) ext.0 NP--
Citrus aurantium (fruit) ext0 NP--
Guarana ext0 NP--
NATURAL HEALTH BLEND660 mg--

Other ingredients: Natural and Artificial flavors, Malic Acid, Waxy Maize, Maltodextrin, Calcium Silicate, Sucralose, Acesulfame Potassium, FD&C Red #40, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USE: (Individual stimulant tolerance may vary). For Pre-Cardio/Workout: With 8 - 12 oz. of cold water (adjust to taste) per scoop or 16-24 oz. of cold water per 2 scoops, mix 1 - 2 scoops 30 minutes before your workout. For Weight Loss and Pre-Cardio/Workout: Mix 1 scoop with 8 - 12 oz. of cold water (adjust to taste) 30 minutes before your workout, then a 2nd scoop 4 hours later. For Weight Loss: Mix 1 scoop with 8 - 12 oz. of cold water (adjust to taste) with breakfast, then a 2nd scoop with lunch.

Mix well and drink shortly thereafter. Consume a minimum 125 fl. oz. of water per day while taking this product. To be used as part of a physical conditioning program.

Shake container prior to each use to redistribute ingredients.

Precautions

To avoid sleeplessness, do not take within 6 hours of bedtime. Do not exceed recommended dose. Do not take more than 2 scoops in a 24 hour period.

Discard after expiration date.

WARNING: KEEP OUT OF REACH OF CHILDREN.

For use by Healthy Individuals only.

Not for use by those under the age of 18.

Do not exceed recommended dose.

Do not use if you are pregnant, nursing, or contemplating pregnancy.

Before consuming seek advice from a health care professional if you are unaware of your current health condition.

Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine.

Do not use for more than 8 weeks.

Consult with your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants.

Consult your physician prior to use if you have a medical condition, including but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high or low blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Do not use if you are prone to dehydration or exposed to excessive heat. Do not use if you suffer from the rare genetic disorder, Hyper Beta-Alaninemia. Discontinue use 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. Do not use if tamper resistant seal is broken.

Contains caffeine.

General Statements

Due to the efficacious levels of CLA and MCT oils present in Cardio Cuts(R), separation may occur after mixing.

Contents may settle after shipping.

Moisture and humidity can cause clumping and discoloration.

First Pre-Cardio/Weight Loss Accelerant

Support for MAXIMUM ENERGY GREATER ENDURANCE QUICKER RECOVERY WEIGHT-LOSS AND TONING

Servings Per Container 20 - 40 Servings

Storage

STORE IN A COOL, DRY PLACE. AVOID EXCESSIVE HEAT.

Formula

Contains caffeine.

Seals/Symbols

Like us on f

AZ ADVANTRA Z(R)

CarnoSyn(R) Carnosine Synthesizer

Powered by BIOENERGY RIBOSE(R)(U)

Formulation

Creatine Free

Gluten Free

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

CarnoSyn(R) is a registered trademark of Natural Alternatives International (NAI), covered by U.S. Patents 5,965,596, 6,172,098, 6,426,361, and 8,067,381.

Advantra Z(R) is a registered trademark of Nutratech, Inc./Zhishin, LLC licensor of U.S. Patents 6,224,873; 6,361,499; 6,340,481; 6,340,482, Canadian Patent 2,248,854 and E.U. Patent 0885008.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

-1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cardio Cuts Black Cherry by NDS label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cardio Cuts Black Cherry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cardio Cuts Black Cherry by NDS

These are the 19 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin D

Interacts with
715 drugs
800 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Vitamin B12

Interacts with
20 drugs
60 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Folate

400 mcg per serving Form: Folic Acid

Magnesium

Interacts with
295 drugs
50 mg per serving Form: Magnesium Aspartate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Calcium

Interacts with
168 drugs
200 mg per serving Form: Calcium Citrate, Calcium Silicate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

CARDIO CUTS(R) CROSS/OVER BLEND

8061 mg per serving

THYRO-LEAN COMPLEX

2870 mg per serving
  • › Tone Tight Blend
  • › Thyro-Support Blend

LEAN-PUMP RECOVERY COMPLEX

3423 mg per serving
  • › Endu-Recover Blend
  • › Vaso-Lean Blend

THERMO-OUTPUT COMPLEX

1108 mg per serving
  • › Rejuvenation Blend
  • › Thermo-Cardio Blend

NATURAL HEALTH BLEND

660 mg per serving

Other (inactive) ingredients: Natural and Artificial flavors, Malic Acid, Waxy Maize, Maltodextrin, Calcium Silicate, Sucralose, Acesulfame Potassium, FD&C Red #40, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cardio Cuts Black Cherry by NDS Drug Interactions

Want to check YOUR meds against Cardio Cuts Black Cherry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,678Drugs
32 Major 1,619 Moderate 27 Minor

Ingredients driving the most interactions

Vitamin D 715
Magnesium 295
Vitamin B6 210
Calcium 168
Vitamin B12 20

Individual Drug Interactions

The ingredients in Cardio Cuts Black Cherry interact with 1,678 drugs. Click any drug to see the details.

5 of the 19 ingredients in Cardio Cuts Black Cherry interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Magnesium Vitamin B6 Calcium Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Cardio Cuts Black Cherry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cardio Cuts Black Cherry, from the product label.

NDS

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Name
FitLife Brands, Inc.
Street Address
4509 South 143rd Street, Suite 1
City
Omaha
State
NE
ZipCode
68137
Pharmacist Counseling Corner

Cardio Cuts Black Cherry by NDS: Common Questions

Does Cardio Cuts Black Cherry by NDS interact with any medications?
Yes. Based on its ingredients, Cardio Cuts Black Cherry has a known interaction with 1,678 medications, including 32 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cardio Cuts Black Cherry contains 19 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Several ingredients lack safety data for pregnancy and breastfeeding—Alpha-Lipoic Acid, Ribose, Raspberry Ketone, Kelp, and Vinpocetine should be avoided. Vitamin B6 and Vitamin D are likely safe at normal pregnancy doses, and L-Glutamine, Folic Acid, and Vitamin B12 are considered safe during pregnancy and lactation. Because this is a complex formula with mixed safety ratings, talk to your doctor or pharmacist before using it if you're pregnant or nursing.
What does the amino acids in this powder do?
The branched-chain amino acids (L-Leucine, L-Isoleucine, and L-Valine) support muscle protein synthesis and recovery after exercise. L-Arginine and L-Tyrosine support blood flow and energy production. L-Glutamine and L-Carnitine fuel muscle and heart function. L-Histidine is needed for normal body functions and immune response. Together, they're meant to support athletic performance and cardiovascular health.
Will this help my athletic performance?
Beta-alanine (CarnoSyn) is possibly effective for athletic performance, and Ribose is possibly ineffective—the evidence is mixed. Phosphatidylserine lacks good evidence for athletic performance. If athletic benefit is your main goal, beta-alanine has the strongest evidence, though it commonly causes a harmless tingling sensation in the skin, especially at the start of dosing.
Are there any common side effects I should know about?
Most reported side effects are mild: L-Glutamine can cause bloating, constipation, nausea, or flatulence; Vitamin B6 at high doses can cause headache or nausea; Alpha-Lipoic Acid may cause headache or nausea; and Beta-alanine often causes harmless tingling and flushing, especially at higher doses or when you first start. If you experience anything more serious, stop and contact your pharmacist or doctor.
Why is Kelp in a 'Cardio' product if it has thyroid effects?
Kelp is a mineral-rich seaweed included for its iodine and trace minerals, which support overall health. However, its high iodine content makes it risky if you have thyroid disease or take thyroid or lithium medications. If you have thyroid issues, avoid this product or check with your doctor first.
Does this product have any fillers or is it just actives?
This powder contains inactive ingredients including malic acid, maltodextrin, calcium silicate, artificial sweeteners (sucralose and acesulfame potassium), and food colorings (FD&C Red #40 and FD&C Blue #1). These are typical excipients that help with taste and texture. It is not a filler-free product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cardio Cuts Black Cherry label
Go deeper

The Full Monographs Behind Cardio Cuts Black Cherry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Cardio Cuts Black Cherry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1,208 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
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  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin B6 32 references
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  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
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  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
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  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
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See these in context on the Vitamin B6 monograph →

Folic Acid 56 references
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  2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
  3. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
  4. Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
  5. Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
  6. Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
  7. Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
  9. Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
  11. Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
  12. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
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Taurine 21 references
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Tyrosine 4 references
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Glycerol 8 references
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Histidine 3 references
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Tartaric Acid 3 references
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L-carnitine 41 references
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Vitamin D 26 references
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Bitter Orange 47 references
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