Clark All-in-One By Dr. Clark Research Association Dr. Clark Zentrum Overview & Drug Interactions

Vitamin D is a fat-soluble vitamin that plays a crucial role in several bodily processes. It helps the body absorb calcium and phosphorus, which are necessary for healthy bones and teeth. It is also important for immune system function and may help to protect against certain diseases. Vitamin D is found in a variety of foods, including fatty fish, egg yolks, and fortified foods such as milk and cereal. It is also produced by the body when the skin is exposed to sunlight. Vitamin D supplements are available in a variety of forms, including tablets, capsules, and liquids. The recommended daily intake of vitamin D varies depending on age, sex, and other factors, and it is important to follow the dosage recommendations provided by a healthcare professional. There are several different forms of vitamin D available, with the two most popular being ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3).

Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Acaí berries are a type of fruit native to the Amazon region of Brazil and grow on the açaí palm tree (Euterpe oleracea). Açaí berries are small, round, and dark purple in color and have a sweet, slightly earthy flavor. Açaí berries are rich in antioxidants, fiber, and heart-healthy fats. They are also a good source of vitamins and minerals, including vitamin A, vitamin C, and calcium. Açaí berries are often marketed as a superfood due to their high antioxidant content, which may help to reduce inflammation and protect against certain diseases. Acai dietary supplements are consumed for their purported health effects and have been marketed to help improve energy levels, boost the immune system, and promote weight loss.

Acerola, also known as the Barbados cherry or West Indian cherry, is a small, red fruit that is native to Central and South America. The fruit is known for its high levels of vitamin C, which is a powerful antioxidant that can help to protect cells from damage caused by free radicals. Acerola is commonly used as a supplement to increase vitamin C intake and it is available in various forms such as capsules, tablets, and powders. It is also often found in juice, jams, and other food products.

Chokeberry, from the aronia shrub, is a fruit widely enjoyed in Eastern Europe and Russia. It serves as a versatile ingredient for various products, including fruit syrup, juice, tea, spreads, jellies, and alcoholic beverages like spirits and wines. The black chokeberry variant is particularly favored for its use in fruit production. Beyond its culinary applications, chokeberry has a traditional association with alleviating symptoms of the common cold.

Astaxanthin is a naturally occurring carotenoid, a class of pigments found in a variety of plants and microorganisms. It is known for its strong antioxidant properties and for giving certain seafood and other organisms their pink or red color. Astaxanthin is commonly used as a dietary supplement and can be found in the form of capsules, tablets, and soft gels. It is promoted for its potential health benefits, including reducing the risk of heart disease, improving skin health, and reducing inflammation. Astaxanthin is a common component in dietary supplements for the eye, marketed to reduce the effects of age-related macular degeneration (AMD).

Beetroot is a type of root vegetable belonging to the Chenopodiaceae family. It is commonly consumed as a food and utilized as a dietary supplement. Beetroot supplements are purported to have a number of potential health benefits, including lowering blood pressure by increasing the production of nitric oxide, improving exercise performance, and reducing inflammation. Dietary supplements containing beetroot are generally in powdered form, and are sometimes standardized by their nitrate content.

Biotin, also known as vitamin H or vitamin B7, is a water-soluble vitamin that plays a role in various metabolic processes in the body. It is necessary for the growth and maintenance of healthy skin, hair, and nails, and is also involved in the metabolism of carbohydrates, fats, and amino acids. Biotin is considered to be generally safe when consumed in the recommended daily amounts but it is important to note that consuming large amounts of biotin-containing supplements or products can cause falsely high or falsely low test results for certain laboratory tests, such as those for thyroid function, hormone levels, and certain biomarkers for certain diseases.

Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Choline is an essential nutrient that is found in many foods, including eggs, and is important for a number of bodily functions, including liver function, brain development, and nerve function. Choline is a precursor to acetylcholine, a neurotransmitter that plays a role in memory, mood, and muscle control. Choline also helps to transport fats out of the liver, which may help to reduce the risk of liver disease. Choline supplements are available in different forms, including choline bitartrate, choline chloride, and phosphatidylcholine. Choline bitartrate is the most common form of choline supplement, but phosphatidylcholine is the form that is found naturally in foods.

Chromium is a trace mineral that is found in small amounts in the human body. It is believed to play a role in the metabolism of carbohydrates, fats, and proteins. It is used as a dietary supplement for its purported ability to help with weight loss and blood sugar control. There is some evidence to suggest that chromium supplements may help to improve blood sugar control in people with type 2 diabetes, although the results of studies on this topic have been mixed. Some studies have found that chromium supplements can improve insulin sensitivity and reduce blood sugar levels in those with poorly controlled diabetes, while others have found no significant effects.

Cranberries are a type of small, tart berry native to North America. They are a rich source of antioxidants, which are substances that help to protect cells from damage caused by harmful substances called free radicals. They are also a good source of vitamin C, fiber, and other nutrients. Cranberry dietary supplements contain concentrated cranberry extract or powdered cranberry fruit. They are often used to prevent or treat urinary tract infections (UTIs), as cranberries are thought to have certain compounds that may help to prevent bacteria from attaching to the urinary tract.

Folate and folic acid are forms of vitamin B9, essential for health. Folate occurs naturally in foods like leafy vegetables, legumes, and fruits, while folic acid is the synthetic form used in supplements and fortified foods. Since 1998, the US has fortified cereals, baking flour, pasta, and bakery items with folic acid to prevent deficiencies. Naturally occurring folate, or pteroylpolyglutamate, has lower bioavailability (40% to 50%) compared to nearly 100% for synthetic folic acid. Foods rich in folate include asparagus, mushrooms, yeast, legumes, spinach, broccoli, lettuce, bananas, melons, oranges, tomatoes, lemons, and animal products like beef liver and kidney. Some supplements contain L-5-methyltetrahydrofolate (L-5-MTHF), a reduced folate form. L-5-MTHF, dependent on vitamin B12 for metabolism, is absorbed faster and more effectively than folic acid, especially in individuals with specific MTHFR genotypes. Studies show that women taking L-5-MTHF had slightly higher red blood cell folate concentrations compared to those taking folic acid, although long-term use results in similar blood levels and effectiveness for preventing neural tube defects.

Ginkgo (Ginkgo biloba) is a tree native to Asia and is known for its distinctive fan-shaped leaves. The extract of the ginkgo leaf is commonly used in traditional medicine and is one of the most popular dietary supplements consumed worldwide. Its most common use is to help improve memory and cognitive function.

Green tea is a type of tea that is made from the leaves of the Camellia sinensis plant. It is native to Asia and is widely consumed throughout the world. Green tea has a mild, slightly grassy flavor and is typically lighter in color and less astringent than black tea. Green tea is a rich source of antioxidants, particularly a group of compounds called catechins. These antioxidants are thought to help protect cells from damage caused by free radicals. Green tea is also a good source of other nutrients, including vitamin C and several B vitamins. Green tea is often consumed for a number of purported health benefits including reducing the risk of heart disease, immune-stimulating effects, and weight loss. Oral green tea supplements, containing dried powder, are most often utilized for the caffeine content and used as an appetite suppressant for weight loss.

Hesperidin is a type of flavonoid, commonly referred to as a 'bioflavonoid', that found in a variety of plants, especially citrus fruits such as oranges and lemons. It is a natural compound and is used in traditional medicine for reducing inflammation, lowering blood pressure, and improving blood flow. It may also have antioxidant and antiviral properties. It is commonly used in dietary supplements. Although data is mixed, it may also have mild sedative effects.

Magnesium is a mineral that is essential for the proper functioning of the body. It plays a role in many important physiological processes, including the contraction and relaxation of muscles, the transmission of nerve impulses, and the regulation of blood pressure. Magnesium is found in a variety of foods, including leafy green vegetables, nuts, and grains, and it is also available as a dietary supplement. There are several different forms of magnesium that are available as supplements, all of which can be used to prevent deficiency. Additionally, magnesium is purported to have several different health benefits, such as improving sleep, reducing muscle cramps, reducing anxiety, and preventing or treating migraines. Although magnesium is essential for health, magnesium-containing foods and supplements can interact with some prescription medications if used at the same time.

Manganese is an essential trace mineral that plays a vital role in various physiological processes within the human body. It is required for proper brain function, bone formation, enzyme activation, and wound healing. Manganese also contributes to metabolism, antioxidant defense, and the formation of connective tissues.

Niacin, also known as vitamin B3, is a water-soluble vitamin found in a variety of foods, including meat, poultry, fish, and fortified grains. It plays a variety of roles in the body, including in the metabolism of carbohydrates, fats, and proteins. It is also necessary for the production of energy in the body and in the synthesis of different hormones. Niacin deficiency is rare in developed countries, however, supplementation has been shown to have several positive benefits. For example, it can reduce the risk of diabetic neuropathy (i.e., nerve pain) and has been shown effective for treating some types of high cholesterol (extended-release niacin is used as a prescription drug in the United States for this purpose). There is a multitude of niacin forms available as dietary supplements, including NADH, niacinamide, and nicotinamide riboside, all with different properties.

Quercetin is a type of flavonoid, which is a class of compounds found in a wide variety of plants and foods. It is purported to have a number of health benefits such as anti-inflammatory, antioxidant, and immune-boosting effects. Studies suggest it may also help to reduce the risk of certain chronic diseases, such as heart disease. In addition, quercetin may have anti-allergic properties and may be helpful in the treatment of allergies and asthma. It is a popular dietary supplement worldwide and is often included in products that contain antioxidants or various vitamins/minerals. Its wide range of potential health benefits mean that it could potentiate the effects of other drugs (e.g., anti-hypertensives), which is why there are an abundant number of potential interactions listed for quercetin.

Resveratrol is a natural compound found in certain plants, including grapes, berries, and peanuts. It has been the subject of numerous scientific studies due to its potential health benefits. Some research suggests that resveratrol may have antioxidant, anti-inflammatory, and cardioprotective effects. It may also have potential as a cancer-fighting agent and may help to improve glucose metabolism and insulin sensitivity.

Saw palmetto (Serenoa repens) is a plant native to the southeastern United States and a member of the Arecaceae family. It is a small, palm-like tree with fan-shaped leaves that produces small, white flowers. The fruit of the plant is a small, dark purple berry, which is what is used in dietary supplements. In traditional medicine, saw palmetto has been used to treat a variety of health conditions, including prostate problems (such as BPH [benign prostatic hyperplasia]) and urinary tract disorders. It is also claimed to have anti-inflammatory and antioxidant properties and to improve hair growth.

Selenium is an essential trace element that plays a crucial role in various physiological functions in the human body. It is often included in dietary supplements due to its antioxidant properties and its contribution to maintaining a healthy immune system. Selenium is important for thyroid function and may also have a role in protecting against certain chronic diseases. However, it's essential to note that excessive selenium intake can be harmful, so it's crucial to adhere to recommended daily allowances and consult with a healthcare professional before taking selenium supplements.

Turmeric is a commonly used spice and a member of the ginger family (Zingiberaceae). It is native to India and other parts of South Asia and is known for its bright orange-yellow color and its warm, slightly bitter flavor. In traditional medicine, turmeric is believed to have a number of health benefits due to its high content of antioxidants and other compounds, such as curcumin. It is thought to have anti-inflammatory and antimicrobial properties, and it is often used to treat a variety of conditions, including joint pain, digestive problems, skin disorders, and respiratory infections. Most dietary supplements that utilize turmeric standardize their products based on a specific amount of curcumin (curcuminoids) per dose. Additionally, turmeric supplements are often paired with black pepper extract (piperine) to improve oral absorption.

Vitamin B12, also known as cobalamin, is a water-soluble vitamin crucial for several bodily functions. It plays a pivotal role in the formation of red blood cells, aiding in the prevention of anemia. Vitamin B12 is essential for maintaining a healthy nervous system and proper brain function, as it is involved in the synthesis of myelin, the protective sheath around nerve fibers. This vitamin is primarily found in animal-based foods such as meat, fish, dairy products, and eggs, making it important for vegetarians and vegans to consider supplementation. A deficiency in vitamin B12 can lead to neurological issues, fatigue, and cognitive impairment.

Vitamin D is a fat-soluble vitamin that plays a crucial role in several bodily processes. It helps the body absorb calcium and phosphorus, which are necessary for healthy bones and teeth. It is also important for immune system function and may help to protect against certain diseases. Vitamin D is found in a variety of foods, including fatty fish, egg yolks, and fortified foods such as milk and cereal. It is also produced by the body when the skin is exposed to sunlight. Vitamin D supplements are available in a variety of forms, including tablets, capsules, and liquids. The recommended daily intake of vitamin D varies depending on age, sex, and other factors, and it is important to follow the dosage recommendations provided by a healthcare professional. There are several different forms of vitamin D available, with the two most popular being ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3).

Vitamin E is a fat-soluble vitamin found naturally in a variety of foods, including vegetable oils, nuts, seeds, and leafy green vegetables. Vitamin E is also available as a dietary supplement and is often added to skincare products. Vitamin E has many roles in the body, including protecting cells from oxidative stress and supporting immune function.

Vitamin E is a fat-soluble vitamin found naturally in a variety of foods, including vegetable oils, nuts, seeds, and leafy green vegetables. Vitamin E is also available as a dietary supplement and is often added to skincare products. Vitamin E has many roles in the body, including protecting cells from oxidative stress and supporting immune function.

Zinc is a mineral that is essential for the proper functioning of the human body. It is involved in many important physiological processes, including immune system function, wound healing, taste, and smell. Zinc is found in a variety of foods, including meat, seafood, and whole grains, and it is also available as a dietary supplement. Zinc supplements may be used to treat or prevent zinc deficiency, which can occur due to certain medical conditions, such as gastrointestinal disorders, alcohol abuse, and certain medications. Zinc supplements may also be used for other purposes, such as to boost the immune system, improve acne, and reduce the severity and duration of colds. There are several different forms of zinc supplements available, including zinc gluconate, zinc acetate, and zinc sulfate. The most common form of zinc supplements is zinc gluconate, which is well absorbed and is less likely to cause stomach-related side effects than other forms of zinc.

Black pepper is a spice made from the dried, unripe fruit of the Piper nigrum plant, which is native to the southwestern coast of India. It is one of the most widely used spices in the world, and it is often utilized to add flavor and heat to a wide variety of dishes. In traditional medicine, black pepper is purported to have a number of health benefits. It is a good source of antioxidants and is thought to have anti-inflammatory properties, which may make it useful in reducing inflammation and swelling in the body. Black pepper is also used as a natural remedy for digestive problems, such as indigestion and bloating, and to boost the immune system. Black pepper is widely used in dietary supplements, specifically, an extract from black pepper known as piperine. Piperine can affect the absorption of many drugs, which is why it has a large number of reported interactions. Oftentimes, these 'interactions' are purposeful, such as when piperine is used with turmeric, to increase its absorption.