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Dietary supplement

High Potency Ostivone Ingredients & Drug Interactions

by Swanson Ultra

High Potency Ostivone label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Potency Ostivone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Potency Ostivone is a dietary supplement by Swanson Ultra with 1 active ingredient. Its ingredients are commonly taken for bone density and osteoporosis, postmenopausal bone loss, athletic performance.Based on those ingredients, 391 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ostivone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Potency Ostivone by Swanson Ultra

Ask about any prescription or over-the-counter medication and we check it for interactions with High Potency Ostivone by Swanson Ultra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Potency Ostivone by Swanson Ultra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

High Potency Ostivone is a single-ingredient supplement containing ipriflavone, a plant compound (isoflavone) structurally similar to estrogen. The capsule also contains microcrystalline cellulose (a binder), gelatin (the capsule shell), and calcium palmitate (an excipient).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: bone density and osteoporosis support.
  • We looked for evidence on: Osteoporosis, postmenopausal bone loss, bone mineral density.
  • The strongest evidence on file: Ipriflavone is rated "Likely Effective" for Osteoporosis (Natural Medicines).

Ipriflavone is rated likely effective for osteoporosis and likely effective for Paget disease (a bone disorder). The evidence supports its use for these bone-related conditions, though you should discuss with your doctor whether it fits your individual situation.

The evidence, ingredient by ingredient Ipriflavone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ipriflavone is generally well tolerated when taken by mouth, though some people report stomach pain, diarrhea, and dizziness. The bigger concern is that it can lower white blood cell counts when used for 6 months or longer, and long-term safety data are limited—caution is warranted if you plan extended use.

The safety data advise against use during pregnancy due to possible estrogen-like effects and insufficient information. Breastfeeding safety is not well established; the data suggest avoiding it.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Ipriflavone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ipriflavone.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 391 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, ask your doctor or pharmacist to check your medications against these drug types: immunosuppressants (most critical), CYP1A2 and CYP2C9 substrate drugs (including antidepressants and estrogen), and theophylline. Moderate interactions are documented for all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with osteoporosis or Paget disease, but it affects how your liver clears many medications and can suppress immune function—making it risky to combine with immunosuppressants, certain antidepressants, muscle relaxants, or theophylline. Check all your medications with your doctor or pharmacist before starting, and watch for low white blood cell counts if you use it long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Potency Ostivone, straight from the product label.

Brand Swanson Ultra
Barcode (UPC) 087614020907
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 188810
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Potency Ostivone by Swanson Ultra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
087614020907
IngredientAmount% DV
Ostivone500 mg--

Other ingredients: Microcrystalline Cellulose, Gelatin, Calcium Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The Most Advanced Nutrition Technology Capsules

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one capsule with water during the morning and evening meals. Use Ostivone in addition to calcium supplementation for best results.

Brand IP Statement(s)

Ostivone is a registered trademark of TSI Health Sciences.

General

SWU090

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Potency Ostivone by Swanson Ultra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Potency Ostivone label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Potency Ostivone by Swanson Ultra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Ostivone

Interacts with
391 drugs
500 mg per serving Form: 7-Isopropoxyisoflavone

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably preven...

Ostivone monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Calcium Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Potency Ostivone by Swanson Ultra Drug Interactions

Want to check YOUR meds against High Potency Ostivone?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
391Drugs
391 Moderate

Ingredients driving the most interactions

Ostivone 391

Individual Drug Interactions

The ingredients in High Potency Ostivone interact with 391 drugs. Click any drug to see the details.

1 of the 1 ingredient in High Potency Ostivone interact with drugs. Each result below shows which ingredient is responsible. Ostivone

Each ingredient & the kinds of drugs it affects

For each ingredient in High Potency Ostivone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ostivone4 drug types · 391 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP2C9 include amitriptyline (Elavil), diazepam (Valium), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), warfarin (Coumadin), zileuton (Zyflo), and others.

Likelihood Possible Evidence D
Immunosuppressants

Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function. Some patients taking ipriflavone experience subclinical lymphocytopenia; avoid concurrent use. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence A
Theophylline

Concomitant use of theophylline and ipriflavone can increase serum theophylline levels. Increased theophylline levels have occurred in two cases after patients started taking ipriflavone. Ipriflavone is thought to decrease theophylline metabolism through competitive inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence D
Ostivone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Potency Ostivone, from the product label.

Swanson Ultra

See all Swanson Ultra products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

High Potency Ostivone by Swanson Ultra: Common Questions

Does High Potency Ostivone by Swanson Ultra interact with any medications?
Yes. Based on its ingredients, High Potency Ostivone has a known interaction with 391 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Potency Ostivone contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my osteoporosis?
Ipriflavone is rated likely effective for osteoporosis, so there's evidence it can help. But it's not risk-free—talk with your doctor about whether it's right for your situation, especially if you take other medications.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against use during pregnancy due to estrogen-like effects, and breastfeeding safety isn't established. If you're pregnant, planning pregnancy, or breastfeeding, speak with your doctor or pharmacist before taking it.
What side effects should I watch for?
Some people experience stomach pain, diarrhea, and dizziness. A bigger concern is that long-term use (6 months or more) can lower your white blood cell count, so your doctor may want to monitor that if you use it regularly.
Why does this interact with so many medications?
Ipriflavone slows how your liver breaks down certain drugs by blocking an enzyme (CYP1A2 and CYP2C9). When your body clears medications more slowly, they can build up and cause toxicity. It also suppresses immune function, which conflicts with immunosuppressant drugs.
Is this safe long-term?
Long-term safety data are limited, and there's concern about white blood cell suppression after 6 months or longer. If you're considering extended use, discuss it with your doctor and ask about monitoring your blood counts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if High Potency Ostivone is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Potency Ostivone label
Go deeper

The Full Monographs Behind High Potency Ostivone’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ipriflavone

Interacts with 391 drugs

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Beca...

Read the full Ipriflavone monograph →
Sources

Sources & How We Checked

High Potency Ostivone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ipriflavone 6 references
  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

See these in context on the Ipriflavone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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