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Dietary supplement

L-Glutamine 1000 mg Ingredients & Drug Interactions

by Solgar

Tablet Or Pill Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Glutamine 1000 mg is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Glutamine 1000 mg by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine, an amino acid your body naturally produces. The tablet also includes several inactive ingredients—microcrystalline cellulose, vegetable cellulose, stearic acid, vegetable magnesium stearate, silica, and vegetable glycerin—which are fillers and binders that help hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Intestinal, immune, and muscle health.
  • We looked for evidence on: Exercise-induced muscle damage, Postoperative recovery, Critical illness (trauma), Oral mucositis, Chemotherapy-induced diarrhea, Radiation-induced diarrhea — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma) (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Crohn disease, Radiation-induced diarrhea.

The evidence for L-glutamine varies by condition. It's rated Effective for sickle cell disease.

For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is Possibly Effective, meaning preliminary studies suggest a benefit but more research is needed to confirm it works reliably.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, glutamine is generally well tolerated in healthy adults. The most common side effects reported are belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, headache, and gastrointestinal pain—especially at higher doses.

Dizziness and headache have been reported, and in rare cases, mania or hypomania in people with bipolar disorder. If you have kidney or liver disease, use this supplement only under your doctor's supervision.

During pregnancy, glutamine is rated Likely Safe. However, there isn't enough reliable safety data for use while breastfeeding unless your doctor or pharmacist advises it—talk with them before taking it if you're nursing.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant (seizure) medications, check your specific drugs with your doctor or pharmacist before starting L-glutamine. Theoretically, glutamine might reduce how well these drugs work, though this hasn't been proven in patients yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may help with sickle cell disease or support recovery after surgery or critical illness, though the evidence for those last two is still building. The main caution is if you take anticonvulsant medications—check with your doctor or pharmacist before starting.

People with kidney or liver problems should also clear it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine 1000 mg, straight from the product label.

Brand Solgar
Barcode (UPC) 033984012547
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79625
Product type Amino Acid/protein
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine 1000 mg by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
033984012547
IngredientAmount% DV
L-Glutamine2000 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Stearic Acid, Vegetable Magnesium Stearate, Silica, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

L-Glutamine is a major fuel source for intestinal, immune, and brain cells. It also comprises nearly 60% of the body’s total free amino acid muscle pool. L-Glutamine regulates nitrogen transport to and from muscle tissue, thereby promoting amino acid balance.

Since 1947

Promotes GI health

Formula

This formulation provides free form l-glutamine to promote optimal absorption and assimilation.

Natural sourced glutamine

Solgar’s KOF-K certification #K-1250

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2016 Solgar, Inc.

General

SOLGB71254 02C

Formulation

Non-GMO Gluten, wheat & dairy free

Suitable for vegans

Free Of: Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor, sweetener, preservatives and color.

Seals/Symbols

GF Certified Gluten-free

K Parve

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take two (2) tablets twice daily, between meals or as directed by a healthcare practitioner.

Precautions

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Storage

Store at room temperature.

See for yourself

L-Glutamine 1000 mg by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Glutamine 1000 mg by Solgar

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
2000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Stearic Acid, Vegetable Magnesium Stearate, Silica, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine 1000 mg by Solgar Drug Interactions

Want to check YOUR meds against L-Glutamine 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Glutamine 1000 mg, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

L-Glutamine 1000 mg by Solgar: Common Questions

Does L-Glutamine 1000 mg by Solgar interact with any medications?
Yes. Based on its ingredients, L-Glutamine 1000 mg has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-glutamine and what does it do?
L-glutamine is an amino acid—a building block your body already makes and uses. This supplement is used primarily to support sickle cell disease (where it's shown to work) and may help with recovery after surgery or serious illness, though more evidence is still being gathered.
Can I take this if I'm pregnant or breastfeeding?
During pregnancy, L-glutamine is rated Likely Safe. While breastfeeding, there isn't enough safety data to know either way—talk with your doctor or pharmacist about whether it's right for you before taking it.
What side effects should I expect?
Most people tolerate it well, but gastrointestinal effects like bloating, constipation, diarrhea, nausea, and stomach pain are common, especially at higher doses. Headache and dizziness have also been reported. If you notice these effects, talk with your pharmacist about adjusting your dose.
Can I take this if I have kidney or liver disease?
Only with your doctor's supervision. People with kidney or liver disease should check with their healthcare provider before taking supplemental glutamine.
Does this work for everything it's marketed for?
Not equally. It's Effective for sickle cell disease, but for HIV-related wasting, postoperative recovery, and critical illness, the evidence is Possibly Effective—meaning early research is promising but we need more proof it works reliably in those situations.
What's in the tablet besides the active ingredient?
The tablet contains microcrystalline cellulose, vegetable cellulose, stearic acid, vegetable magnesium stearate, silica, and vegetable glycerin—all inactive ingredients that help form and stabilize the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutamine 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine 1000 mg label
Go deeper

The Full Monographs Behind L-Glutamine 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Glutamine 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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