Milk It Lactation Blend Ingredients & Drug Interactions
by Oat Mama
What is this page for?
First and foremost: checking Milk It Lactation Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Milk It Lactation Blend is a dietary supplement by Oat Mama with 3 active ingredients. Its ingredients are commonly taken for digestive upset and poor appetite, boosting bile flow, general bitter tonic.Based on those ingredients, 1,376 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nigella, Horseradish Tree, Blessed Thistle. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Milk It Lactation Blend by Oat Mama
Ask about any prescription or over-the-counter medication and we check it for interactions with Milk It Lactation Blend by Oat Mama — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Milk It Lactation Blend by Oat Mama
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Milk It Lactation Blend contains three active ingredients. Blessed thistle is traditionally used to support milk supply and lactation.
Horseradish tree (moringa) is also traditionally used to boost milk production. Black seed (nigella) rounds out the blend.
The product is delivered in capsule form with rice flour, hypromellose, and purified water as inactive ingredients.
Does it work?
Not established
The evidence for these ingredients in lactation isn't established in our data. Blessed thistle and horseradish tree have insufficient reliable evidence to rate their use for lactation or digestive symptoms.
Black seed shows possibly effective ratings for acne, hay fever, asthma, stomach bacteria (helicobacter pylori), and diabetes—but those aren't lactation claims. If you're considering this blend specifically for milk supply, that's a question worth asking your doctor or a lactation consultant.
How safe is it?
Well-documented data
Blessed thistle is often well tolerated in small amounts, but human safety data are limited, and large doses can cause nausea or vomiting. It's traditionally thought to affect the uterus and lacks pregnancy safety data, so it's best avoided during pregnancy.
Horseradish tree leaf products appear generally well tolerated as food, but high-quality safety data are limited. Medicinal amounts of root and bark may stimulate the uterus and shouldn't be used in pregnancy.
Black seed is likely safe in food amounts, but higher supplement doses are less studied long-term. In clinical trials, black seed most commonly caused constipation, gastric burning or discomfort, nausea, and vomiting.
One case of relatively severe menstrual bleeding occurred in a clinical trial. Both horseradish tree and black seed are traditionally used to support milk, but safety hasn't been well studied in lactating people—check with your doctor first.
Meds to double-check
Moderate interaction found
Before taking this product, check your medications against these categories. Black seed interacts Moderately with blood pressure medications, blood thinners and antiplatelet drugs, diabetes medications, water pills (diuretics), immunosuppressants, cyclosporine, sedatives and other CNS depressants, and serotonergic drugs like some antidepressants.
Horseradish tree interacts Moderately with medications metabolized by CYP3A4 enzymes, levothyroxine (thyroid replacement), and P-glycoprotein substrates. Blessed thistle has Minor interactions with stomach acid–reducing medications including H2-blockers, antacids, and proton pump inhibitors.
Use the medication checker on this page to search your exact drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This is a traditional lactation blend, but we don't have strong evidence that it works for milk supply in our data. More importantly, if you take any medications—especially for blood pressure, bleeding, blood sugar, immune function, or thyroid—you need to check with your pharmacist before starting this product.
The interactions are real and sometimes serious.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Milk It Lactation Blend, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Milk It Lactation Blend by Oat Mama, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Blessed Thistle | 250 mg | -- |
| Horseradish Tree | 250 mg | -- |
| Nigella | 200 mg | -- |
Other ingredients: Rice Flour, Hypromellose, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Do not exceed recommended dose. Do not use if safety seal is damaged or missing.
Keep out of reach of children. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before use.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before use.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Fenugreek free
Whether your supply has taken a dip due to sickness, teething, or going back to work, we have you taken care of, mama.
Supports a healthy milk supply
Made in the USA
Formula
Our Milk It Lactation Blend uses traditional herbs like moringa, nigella seed, and blessed thistle to help increase milk supply in breastfeeding mothers.
General Statements
You're doing a good job, mama. Let's mother together. To learn about our other motherhood products visit: oatmama.com
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Take two capsules, three times daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Milk It Lactation Blend by Oat Mama label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Milk It Lactation Blend by Oat Mama
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Blessed Thistle
Interacts with36 drugs
Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking,...
Blessed Thistle monograph & interactionsHorseradish Tree
Interacts with869 drugs
Moringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition is common....
Horseradish Tree monograph & interactionsNigella
Interacts with912 drugs
Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with ear...
Nigella monograph & interactionsOther (inactive) ingredients: Rice Flour, Hypromellose, Water, Purified. These complete the product’s ingredient list but are not active constituents.
Milk It Lactation Blend by Oat Mama Drug Interactions
HelloPharmacist Interaction Report
Milk It Lactation Blend by Oat Mama contains three active ingredients, and there are documented interactions with a total of 1,358 individual medications across all three.
The most serious concern is black seed (nigella), which carries multiple Moderate-severity interactions. Black seed may lower blood pressure when used alongside blood pressure medications (antihypertensive drugs), raising the risk of dangerously low blood pressure.
It can also increase bleeding risk if you take blood thinners or antiplatelet drugs like aspirin or warfarin, interfere with immunosuppressant medications, raise the risk of low blood sugar (hypoglycemia) if you're on diabetes drugs, increase potassium loss if you take water pills (diuretics), and theoretically reduce levels of cyclosporine.
Read the full breakdown — every affected drug type, severity by severity
Black seed additionally carries Moderate-severity interactions with drugs that affect the brain and nervous system. It may cause additive sedation if combined with CNS depressants (sedatives, sleep aids), and there's a theoretical risk of serotonin syndrome if you take serotonergic drugs like certain antidepressants.
Horseradish tree (moringa) has three Moderate-severity interactions: it may unpredictably raise or lower levels of medications metabolized by the CYP3A4 enzyme, antagonize thyroid replacement therapy (levothyroxine), and increase levels of drugs transported by P-glycoprotein. Blessed thistle carries Minor-severity interactions with stomach acid–reducing medications: it may theoretically reduce the effectiveness of H2-blockers, antacids, and proton pump inhibitors (PPIs).
Alternatives don't exist among these three ingredients—all three have documented interactions. Check your exact medications using the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Milk It Lactation Blend?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Milk It Lactation Blend interact with 1,376 drugs. Click any drug to see the details.
3 of the 3 ingredients in Milk It Lactation Blend interact with drugs. Each result below shows which ingredient is responsible. Nigella Horseradish Tree Blessed Thistle
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
NigellaImmunosuppressants Moderate
Interaction Summary
Theoretically, black seed might interfere with immunosuppressive therapy.
Read the full Nigella + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
NigellaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nigella + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
NigellaAnticoagulant/antiplatelet Drugs, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nigella + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Nigella + Acarbose interactionHorseradish TreeAntidiabetes Drugs Minor
Interaction Summary
Theoretically, moringa might have additive effects when used with antidiabetes drugs; however, research is conflicting.
Read the full Horseradish Tree + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
NigellaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Nigella + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
NigellaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nigella + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
NigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nigella + Acetaminophen, Aspirin interactionHorseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Nigella + Acetaminophen, Aspirin, Caffeine interactionHorseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Acetaminophen, Butalbital, Caffeine, Codeine interactionNigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Butalbital, Codeine interactionHorseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Butalbital, Codeine Phosphate interactionHorseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionHorseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Acetaminophen, Caffeine, Codeine interactionNigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Caffeine, Codeine, Salicylamide interactionHorseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Acetaminophen, Caffeine, Dihydrocodeine interactionNigellaCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Milk It Lactation Blend — through 1 ingredient. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Acetaminophen, Caffeine, Pyrilamine interactionNigellaDiuretic Drugs Moderate
Interaction Summary
Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Nigella + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionNigellaSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Nigella + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionNigellaCns Depressants, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Read the full Nigella + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Nigella + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionHorseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionNigellaSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Nigella + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
NigellaSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Nigella + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionHorseradish TreeCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Horseradish Tree + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Milk It Lactation Blend — through 2 ingredients. Tap an ingredient for the detail:
Horseradish TreeCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Read the full Horseradish Tree + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionNigellaSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Read the full Nigella + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Milk It Lactation Blend with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Nigella
Anticoagulant/Antiplatelet Drugs
Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that black seed extract can inhibit platelet aggregation and clotting, and increase bleeding time. In addition, decreased platelet counts have occurred in a human case report and in animal research.
Antidiabetes Drugs
Theoretically, taking black seed with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research and numerous animal studies suggest that black seed, especially its constituent thymoquinone, can have hypoglycemic effects.
Antihypertensive Drugs
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Clinical research suggests that black seed powder and oil might reduce blood pressure by 2-3 mmHg. In animal research, black seed modestly reduces blood pressure and concomitant use of black seed and amlodipine (Norvasc) or metoprolol (Lopressor) increased the blood pressure lowering effects of these drugs.
Clopidogrel (Plavix)
Theoretically, black seed may increase the risk of bleeding if used with clopidogrel.
Animal research shows that taking black seed extract daily for 2 weeks prior to a single dose of clopidogrel increases maximum concentrations of clopidogrel by approximately 31% and modestly decreases oral clearance. Furthermore, bleeding time was increased by 12%. This has not been shown in humans.
Cns Depressants
Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.
Animal research suggests that black seed may have CNS depressant effects.
Cyclosporine (Neoral, Sandimmune)
Theoretically taking black seed might reduce the levels and clinical effects of cyclosporine.
In animal research, black seed extract decreased the maximal levels of cyclosporine in the blood by 35.5%. This has not been shown in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin by a mechanism possibly related to the inhibition of CYP2C9. The effect of black seed on CYP2C9 is unclear. This has not been shown in humans.
Diuretic Drugs
Theoretically, taking black seed with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Black seed extract has shown diuretic effects in animals, which could theoretically increase potassium loss. This has not been shown in humans.
Immunosuppressants
Theoretically, black seed might interfere with immunosuppressive therapy.
Animal and in vitro studies suggest that black seed might stimulate immune function. However, other animal studies suggest that black seed may suppress immune function.
Phenytoin (Dilantin)
Theoretically, black seed might increase or decrease levels and effects of phenytoin.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of phenytoin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). However, animal research shows that black seed decreases the maximum concentration of and total systemic exposure to phenytoin by 57% and 87%, respectively. This seems to be related to increased clearance and steady state volume of distribution. This interaction has not been shown in humans.
Serotonergic Drugs
Theoretically, combining serotonergic drugs with black seed might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.
Animal research suggests that black seed can increase brain serotonin levels. In one case report, a 35-year-old man undergoing endoscopic surgery experienced immediate postoperative serotonin syndrome that was likely associated with the use of black seed oil 600 mg daily starting 4 days before surgery, and precipitated by the use of serotonergic pain medications, including fentanyl and oxycodone. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using black seed with serotonergic drugs.
Sildenafil (Viagra)
Theoretically, black seed might reduce plasma levels and the therapeutic effects of sildenafil.
Animal research shows that black seed reduces the total systemic exposure to sildenafil by 43%. So far, this interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, black seed might increase levels of warfarin and increase the risk of bleeding.
In vitro research suggests that thymoquinone, a constituent of black seed, can decrease the metabolism of warfarin. This effect may be due to inhibition of cytochrome P450 2C9 (CYP2C9). The effect of black seed on warfarin metabolism is unclear. This has not been shown in humans.
Prednisolone
Theoretically black seed might reduce plasma levels and therapeutic effects of prednisolone.
In animal research, oral administration of a single dose of black seed oil 15 minutes prior to oral prednisolone decreases the prednisolone maximum plasma concentration by 65% and area under the curve by 25%. This has not been shown in humans.
Horseradish Tree
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.
Some in vitro research suggests that moringa inhibits cytochrome P450 3A4 (CYP3A4). However, other in vitro research suggests that moringa extract induces CYP3A4 enzymes. A pharmacokinetic study in patients with HIV shows no change in the pharmacokinetics of nevirapine, which is partially metabolized by CYP3A4, when administered concomitantly with moringa leaf powder 1.85 grams daily for 14 days.
Levothyroxine (Synthroid, Others)
Theoretically, moringa leaf can antagonize the effects of levothyroxine.
Animal research suggests that moringa aqueous leaf extract might reduce serum triiodothyronine (T3) concentrations by inhibiting the peripheral conversion of thyroxine (T4) to T3.
P-Glycoprotein Substrates
Theoretically, moringa leaf extract might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that moringa leaf extract inhibits renal P-glycoprotein transport activity. So far, this reaction has not been reported in humans.
Antidiabetes Drugs
Theoretically, moringa might have additive effects when used with antidiabetes drugs; however, research is conflicting.
Animal research shows that moringa can lower blood glucose levels. However, research in humans has not shown consistent blood glucose lowering effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, moringa might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that moringa extract induces CYP1A2 enzymes.
Nevirapine (Viramune)
Moringa leaf is unlikely to have a clinically significant interaction with nevirapine.
Nevirapine is partially metabolized by cytochrome P450 3A4 (CYP3A4). In vitro evidence suggests that moringa inhibits CYP3A4. However, a pharmacokinetic study in patients with HIV shows no change in nevirapine pharmacokinetics when administered concomitantly with moringa leaf powder 1.85 grams daily for 14 days.
Blessed Thistle
Antacids
Theoretically, blessed thistle might decrease the effectiveness of antacids.
There are reports that blessed thistle increases stomach acid.
H2-Blockers
Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.
There are reports that blessed thistle increases stomach acid.
Proton Pump Inhibitors (Ppis)
Theoretically, blessed thistle might decrease the effectiveness of PPIs.
There are reports that blessed thistle increases stomach acid.
Brand information
Manufacturer and brand details for Milk It Lactation Blend, from the product label.
Oat Mama
See all Oat Mama products- Name
- Oat Mama
- Street Address
- PO Box 17250
- City
- Seattle
- State
- WA
- ZipCode
- 98127
- Web Address
- oatmama.com
Milk It Lactation Blend by Oat Mama: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Milk It Lactation Blend’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Blessed Thistle
Interacts with 36 drugsBlessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It...
Read the full Blessed Thistle monograph → Herb & supplement monographMoringa
Interacts with 869 drugsMoringa is a nutrient-rich plant whose leaves are widely used as a food and supplement, especially in parts of the world where malnutrition is common. Early research hints at possible benefi...
Read the full Moringa monograph → Herb & supplement monographBlack Seed
Interacts with 912 drugsBlack seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no...
Read the full Black Seed monograph →Sources & How We Checked
Milk It Lactation Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 85 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Blessed Thistle 2 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Moringa 23 references
- Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003;84:105-8. PubMed
- Tahiliani P, Kar A. Role of Moringa oleifera leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacol Res 2000;41:319-23. PubMed
- Jaiswal D, Kumar Rai P, Kumar A, et al. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmcol 2009;123:392-6. PubMed
- Bour S, Visentin V, Prevot D, et al. Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats. J Physiol Biochem 2005;61:371-9. PubMed
- Iffiu-Soltesz Z, Wanecq E, Lomba A, et al. Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. Pharmacol Res 2010;61:355-63. PubMed
- Monera TG, Wolfe AR, Maponga CC, et al. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries 2008;2:379-83.
- Estrella M, Mantaring J, David G, Taup M. A double blind, randomised controlled trial on the use of malunggay (Moringa oleifera) for augmentation of the volume of breastmilk among non-nursing mothers of preterm infants. Philipp J Pediatr 2000;49:3-6.
- Morton, J. F. The Horseradish Tree, Moringa Pterygosperma (Moringaceae) - a boon to arid lands? Economic Botany 1991;45:318-333. DOI
- Espinosa-Kuo CL. A Randomized Controlled Trial on the Use of Malunggay (Moringa oleifera) for Augmentation of the Volume of Breastmilk Among Mothers of Term Infants. Filipino Family Physician. 2005;43(1):26-33.
- King JS, Raguindin PFN, Dans LF. Moringa oleifera (Malunggay) as a Galactagogue for Breastfeeding Mothers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Philipp J Pediatr 2013;61(2):34-42.
- Singh D, Choudhury S, Singh TU, Garg SK. Pharmacodynamics of uterotonic effect of Moringa oleifera flowers extract. J Vet Pharmcol Toxicol 2008;7(1-2):12-15.
- William F, Lakshminarayanan S, Chegu H. Effect of some Indian vegetables on the glucose and insulin response in diabetic subjects. International Journal of Food Sciences and Nutrition 1993;44(3): 191-195. DOI: 10.3109/09637489309017439 DOI
- Monera-Penduka TG, Maponga CC, Wolfe AR, Wiesner L, Morse GD, Nhachi CF. Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS Res Ther. 2017;14:12. doi: 10.1186/s1 PubMed
- Witharana EWRA, Wijetunga WMGASTB, Wijesinghe SKJ. Stevens - Johnson syndrome (SJS) following murunga leaf (Moringa oleifera) consumption. Ceylon Med J 2018;63(4):188-9.
- Nur R, Demak IPK, Radhiah S, Rusydi M, Mantao E, Larasati RD. The effect of moringa leaf extracton increasing hemoglobin and bodyweight in post-disaster pregnant women. Enferm Clin. 2020;30 Suppl 4:79-82. DOI
- Taweerutchana R, Lumlerdkij N, Vannasaeng S, Akarasereenont P, Sriwijitkamol A. Effect of Moringa oleifera Leaf Capsules on Glycemic Control in Therapy-Naïve Type 2 Diabetes Patients: A Randomized Placebo Controlled Study. Evid Based Complement Alternat M
- Sumiaty, Tahir A, Burhanuddin B, Nurhaedar J, Veni H. The effect of moringa leaves on pregnancy on growth and morbidity of 6-11 month. Enferm Clin. 2020;30 Suppl 4:104-108. DOI
- Ulmy MN, Tahir A, Arsunan AA, Burhanuddin B, Veni H. Effect of moringa leaves during pregnancy on growth and morbidity in 0-5 months. Enferm Clin. 2020;30 Suppl 4:61-65. DOI
- Amaeze O, Marques ES, Wei W, et al. Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. Curr Drug Metab. 2021;22(14):1103-1113. PubMed
- Ebhohon E, Miller D. Moringa Oleifera leaf extract induced pulmonary embolism-a case report. Int J Emerg Med 2022;15(1):16. PubMed
- Basri H, Hadju V, Zulkifli A, Syam A, Indriasari R. Effect of Moringa oleifera supplementation during pregnancy on the prevention of stunted growth in children between the ages of 36 to 42 months. J Public Health Res 2021;10(2):2207.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Amsler E, Mahevas T, Soria A, Barbaud A. Fixed food eruption to Moringa oleifera. Contact Dermatitis 2023;89(4):301-302.
Black Seed 60 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
- Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
- Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9. PubMed
- Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008;22:447-52.
- Zaoui, A., Cherrah, Y., Lacaille-Dubois, M. A., Settaf, A., Amarouch, H., and Hassar, M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000;55(3):379-382.
- Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. PubMed
- Meral, I., Yener, Z., Kahraman, T., and Mert, N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet.Med A Physiol Pathol.Clin Med 2001;48(1
- Al Jishi, S. A. and Abuo, Hozaifa B. Effect of Nigella sativa on blood hemostatic function in rats. J Ethnopharmacol. 2003;85(1):7-14. PubMed
- Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
- Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88(1):63-68. PubMed
- Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
- Islam, S. N., Begum, P., Ahsan, T., Huque, S., and Ahsan, M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother.Res. 2004;18(5):395-398.
- Fararh, K. M., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., and Takewaki, T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet.Sci 2004;77(2):123-129. PubMed
- Awad, E. M. and Binder, B. R. In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa. Phytomedicine 2005;12(3):194-202. PubMed
- El Obeid, A., Al Harbi, S., Al Jomah, N., and Hassib, A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine. 2006;13(5):324-333.
- Abbas, A. T., Abdel-Aziz, M. M., Zalata, K. R., and Tel, Abd Al-Galel. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. Egypt J Im
- Kaleem, M., Kirmani, D., Asif, M., Ahmed, Q., and Bano, B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp.Biol. 2006;44(9):745-748.
- Hawsawi, Z. A., Ali, B. A., and Bamosa, A. O. Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann.Saudi Med 2001;21(3-4):242-244.
- Massadeh, A. M., Al Safi, S. A., Momani, I. F., Al Mahmoud, M., and Alkofahi, A. S. Analysis of cadmium and lead in mice organs: effect of Nigella sativa L. (Black Cumin) on the distribution and immunosuppressive effect of cadmium-lead mixture in mice. B PubMed
- Akhondian, J., Parsa, A., and Rakhshande, H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13(12):CR555-CR559.
- Meddah, B., Ducroc, R., El Abbes, Faouzi M., Eto, B., Mahraoui, L., Benhaddou-Andaloussi, A., Martineau, L. C., Cherrah, Y., and Haddad, P. S. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol. PubMed
- Najmi, A., Nasiruddin, M., Khan, R. A., and Haque, S. F. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev.Ctries. 2008;28(1):11-14.
- al Sheikh, O. A. and Gad el-Rab, M. O. Allergic contact dermatitis: clinical features and profile of sensitizing allergens in Riyadh, Saudi Arabia. Int J Dermatol. 1996;35(7):493-497.
- Steinmann, A., Schatzle, M., Agathos, M., and Breit, R. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermatitis 1997;36(5):268-269.
- Al-Jenoobi FI, Al-Suwayeh SA, Muzaffar I, et al. Effects of Nigella sativa and Lepidium sativum on cyclosporine pharmacokinetics. Biomed Res Int 2013;2013:953520.
- Arslan E, Sayin S, Demirbas S, et al. A case study report of acute renal failure associated with Nigella sativa in a diabetic patient. J Integr Med 2013;11:64-6. PubMed
- Bamosa AO, Kaatabi H, Lebdaa FM, et al. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010;54:344-54.
- Bonhomme A, Poreaux C, Jouen F, et al. Bullous drug eruption to Nigella sativa oil: Consideration of the use of a herbal medicine - clinical report and review of the literature. J Eur Acad Dermatol Venereol 2017;31:e217-e219.
- Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled
- Kaatabi H, Bamosa AO, Badar A, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial. PLoS One 2015;10:e0113486. PubMed
- Mohtashami R, Huseini HF, Heydari M, et al. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol 2015;175:147-52. PubMed
- Perveen T, Haider S, Zuberi NA, et al. Increased 5-HT levels following repeated administration of Nigella sativa L. (Black Seed) oil produce antidepressant effects in rats. Sci Pharm 2013;82:161-70. PubMed
- Sahebkar A, Soranna D, Liu X, et al. A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure. J Hypertens 2016;34:2127-35. PubMed
- Shawki M, El Wakeel L, Shatla R, et al. The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study. Epileptic Disord 2013;15:295-301. PubMed
- Muneera KE, Majeed A, Naveed AK. Comparative evaluation of nigella sativa (Kalonji) and simvastatin for the treatment of hyperlipidemia and in the induction of hepatotoxicity. Pak J Pharm Sci. 2015 Mar;28(2):493-8.
- Mahdavi R, Namazi N, Alizadeh M, Farajnia S. Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial. Food Funct. 2015;6(6):2041-8. PubMed
- Fallah Huseini H, Amini M, Mohtashami R, et al. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013;27(12):1849-53.
- Dehavay F, Kolivras A, Scheers C. Local and systemic adverse skin reactions following the use of herbal products believed to contain Nigella sativa seeds and oil. Contact Dermatitis. 2019 Mar;80(3):176-177.
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- Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FBI. Effect of Nigella sativa and fenugreek on the pharmacokinetics and pharmacodynamics of amlodipine in hypertensive rats. Curr Drug Metab. 2020;21(4):318-325. PubMed
- Moustafa HAM, El Wakeel LM, Halawa MR, Sabri NA, El-Bahy AZ, Singab AN. Effect of Nigella sativa oil versus metformin on glycemic control and biochemical parameters of newly diagnosed type 2 diabetes mellitus patients. Endocrine 2019;65(2):286-94. PubMed
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- Wang X, Jiang A, Batra V. Severe thrombocytopenia associated with black seed oil and evening primrose oil. Cureus. 2020;12(6):e8390. PubMed
- Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
- Thomas JV, Mohan ME, Prabhakaran P, Das S S, Maliakel B, I M K. A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study. Toxicol PubMed
- Assier H, Kouby F, Ingen-Housz-Oro S, Roux C. Severe allergic contact connubial dermatitis to Nigella Sativa Seed Oil due to repeated contacts to beard cosmetics. Contact Dermatitis 2022. PubMed
- Koshak AE, Koshak EA, Mobeireek AF, et al. Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial. Complement Ther Med 2021;61:102769. PubMed
- Hadi S, Daryabeygi-Khotbehsara R, Mirmiran P, et al. Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res 2021;35(7):3747-3755.
- Ali SM, Chen P, Sheikh S, et al. Thymoquinone with metformin decreases fasting, post prandial glucose, and HbA1c in type 2 diabetic patients. Drug Res (Stuttg) 2021;71(6):302-306. PubMed
- Tavakoli-Rouzbehani OM, Abbasnezhad M, Kheirouri S, Alizadeh M. Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double-blind, placebo-control
- Fargeas M, Calugareanu A, Ben-Said B. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after topical use of Nigella sativa (black cumin) oil. Contact Dermatitis 2022;87(2):203-204.
- Wang Z, Wang Z, Wang X, et al. Potential food-drug interaction risk of thymoquinone with warfarin. Chem Biol Interact. 2022;365:110070. PubMed
- Wang Z, Wang X, Wang Z, et al. Potential herb-drug interaction risk of thymoquinone and phenytoin. Chem Biol Interact. 2022;353:109801. PubMed
- Al-Mohizea AM, Ahad A, El-Maghraby GM, et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet. 2015;40(2):219-24. PubMed
- Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, et al. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs. Phytother Res. 2013;27(12):1800-4.
- Abutaima R, Al-Ebini Y, Alkofahi A, et al. In vivo assessment of black seed oil single dose on prednisolone pharmacokinetics. J Pharm Pharmacol 2024;76(1):57-63.
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC