Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Sweet Wormwood Ingredients & Drug Interactions

by ZenMen

Sweet Wormwood label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sweet Wormwood against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sweet Wormwood is a dietary supplement by ZenMen with 1 active ingredient. Its ingredients are commonly taken for malaria (traditional), fever, inflammation.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sweet Wormwood Herb Extract, Liquid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sweet Wormwood by ZenMen

Ask about any prescription or over-the-counter medication and we check it for interactions with Sweet Wormwood by ZenMen — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Sweet Wormwood by ZenMen

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

ZenMen Sweet Wormwood contains one active ingredient: Sweet Wormwood Herb Extract in liquid form. Sweet Wormwood (also called Sweet Annie) is a traditional botanical used in herbal medicine.

The liquid is made with organic cane alcohol, purified water, and vegetable glycerin as inactive ingredients that serve as the base and preservative.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Sweet Annie's overall clinical evidence instead.

Moderate

Some clinical evidence supports Sweet Annie for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Allergic rhinitis (hay fever) — rated "Possibly Effective" (Natural Medicines).

The evidence for Sweet Wormwood is limited. It's possibly effective for allergic rhinitis (hay fever), meaning there's some research support but it's not definitive.

For other uses listed — nonalcoholic fatty liver disease, malaria, and osteoarthritis — we don't have enough reliable evidence to rate whether it works. If you're considering this for a specific condition, talk with your pharmacist about what the research actually shows for your situation.

The evidence, ingredient by ingredient Sweet Annie

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, Sweet Wormwood is generally well tolerated, though nausea and vomiting are the most common side effects when people take it. More seriously, there is concern that Sweet Annie can damage the liver — a rare but documented risk.

One case showed hepatitis (liver inflammation) develop after taking a related compound for 10 days; symptoms resolved after stopping it. A mild allergic reaction (rash and cough) has been reported rarely, and if you're allergic to Sweet Annie, taking it under the tongue may cause numbness or throat itching.

Quality and dose vary widely between products, and this supplement should never replace proven medical treatments.

Side effects, ingredient by ingredient Sweet Annie

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sweet Annie.
  • The most serious interaction on file is rated Moderate.
  • For scale: 890 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting ZenMen Sweet Wormwood, double-check any medication metabolized by your liver's cytochrome P450 3A4 or 2B6 enzymes — these are moderate-severity interactions where drug levels may change unpredictably. Also check any drug that can harm the liver, since Sweet Wormwood carries that same risk and taking both together could compound the problem.

Use the medication search tool on this page with your exact prescriptions, then confirm with your pharmacist before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Sweet Wormwood may be worth considering if you have allergic rhinitis and are interested in a botanical option, but it comes with real liver concerns and can interfere with many common medications. If you take anything for heart, blood pressure, seizures, or immune health, you need to check your specific drugs with a pharmacist first.

Never use this as a replacement for proven treatments, and keep in mind that quality varies widely between products.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sweet Wormwood, straight from the product label.

Brand ZenMen
Barcode (UPC) X003ZDFSLV
Net contents 2 Fluid Ounce(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 310004
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sweet Wormwood by ZenMen, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.6 mL
Maximum serving Sizes:
1.6 mL
Servings per container
37
UPC/BARCODE
X003ZDFSLV
IngredientAmount% DV
Sweet Wormwood Herb Extract, Liquid1.6 mL--

Other ingredients: organic Cane Alcohol, Water, Purified, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Master Herbalist Formulated

Want to learn more about this herb? Scan me

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take two (2) droppers, 2-4 times daily or as recommended by a healthcare professional. For best results, use continuously for 3 months.

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult with a physician before taking this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult with a physician before taking this or any dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

From the Farm Tick strength helper

Gluten free Non GMO

Vegan

Seals/Symbols

Manufactured in the USA GMP Vegan

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sweet Wormwood by ZenMen label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sweet Wormwood label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sweet Wormwood by ZenMen

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.6 mL Dosage formLiquid Servings per container37 Amounts shown are per serving.

Sweet Wormwood Herb Extract, Liquid

Interacts with
889 drugs
1.6 mL per serving Form: Artemisia annua Herb Extract, Liquid

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studie...

Sweet Wormwood Herb Extract, Liquid monograph & interactions

Other (inactive) ingredients: Organic Cane Alcohol, Water, Purified, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sweet Wormwood by ZenMen Drug Interactions

Want to check YOUR meds against Sweet Wormwood?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
889Drugs
889 Moderate

Ingredients driving the most interactions

Sweet Wormwood Herb Extract, Liquid 889

Individual Drug Interactions

The ingredients in Sweet Wormwood interact with 889 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sweet Wormwood interact with drugs. Each result below shows which ingredient is responsible. Sweet Wormwood Herb Extract, Liquid

Each ingredient & the kinds of drugs it affects

For each ingredient in Sweet Wormwood with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sweet Wormwood Herb Extract, Liquid3 drug types · 889 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.

Likelihood Possible Evidence D
Sweet Wormwood Herb Extract, Liquid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sweet Wormwood, from the product label.

ZenMen

See all ZenMen products
Name
Zenmen
Street Address
18695 Pony Exp Dr.
City
Parker
State
CO
ZipCode
80134
Web Address
ZenmenHealth.com
Pharmacist Counseling Corner

Sweet Wormwood by ZenMen: Common Questions

Does Sweet Wormwood by ZenMen interact with any medications?
Yes. Based on its ingredients, Sweet Wormwood has a known interaction with 889 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sweet Wormwood contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No, the safety data advises against it because of possible harm to the developing baby. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before considering any herbal supplement.
Is it safe to breastfeed while taking Sweet Wormwood?
There isn't enough safety information available, so we recommend avoiding it while breastfeeding. Talk with your pharmacist or doctor for personalized advice about your situation.
What are the side effects?
The most common are nausea and vomiting when taken by mouth. Rarely, it may cause liver damage — one documented case showed hepatitis that resolved after stopping the supplement. A mild allergic reaction with rash or cough has also been reported once; if you're allergic to Sweet Annie, it can cause numbness or itching under the tongue.
Does it actually work for hay fever?
It's possibly effective for allergic rhinitis, which means there's some research backing it, but the evidence isn't strong or conclusive. Ask your pharmacist whether the research supports using it for your specific symptoms.
Why does the liquid have alcohol in it?
The organic cane alcohol is an inactive ingredient that helps preserve and extract the active herb. It also serves as the liquid base for the supplement.
Can this replace my regular medical treatment?
No. Quality and dose vary widely between products, and this supplement should never replace proven treatments. Always discuss any supplement with your doctor, especially if you're managing an active health condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sweet Wormwood is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sweet Wormwood label
Go deeper

The Full Monographs Behind Sweet Wormwood’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sweet Annie

Interacts with 889 drugs

Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studied for malaria, the herb itself as a supp...

Read the full Sweet Annie monograph →
Sources

Sources & How We Checked

Sweet Wormwood's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sweet Annie 11 references
  1. Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
  2. Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
  3. Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
  4. Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
  5. Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
  6. Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
  7. Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
  8. Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
  9. Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
  10. Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
  11. Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed

See these in context on the Sweet Annie monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team