W-W Ingredients & Drug Interactions
by Pure Herbs
What is this page for?
First and foremost: checking W-W against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
W-W is a dietary supplement by Pure Herbs with 5 active ingredients. Its ingredients are commonly taken for intestinal parasites and worms, digestive complaints, antimicrobial and antifungal support.Based on those ingredients, 787 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cascara sagrada Bark Extract, Wormwood Aerial Part Extract, Pumpkin extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against W-W by Pure Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with W-W by Pure Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of W-W by Pure Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
W-W is a 5-ingredient liquid blend. The active ingredients are Black Walnut Husk Extract, Cascara sagrada Bark Extract, Wormwood Aerial Part Extract, Pumpkin extract, and Male Fern Root Extract — traditional herbal components blended together as a proprietary formula.
There are no inactive ingredients listed.
Does it work?
Not established
The evidence supporting these ingredients is limited. Black Walnut Husk Extract has insufficient reliable evidence for coronary heart disease or wound healing.
Cascara sagrada shows possibly ineffective evidence for bowel prep and insufficient evidence for constipation. Wormwood Aerial Part Extract, Pumpkin extract, and Male Fern Root Extract all have insufficient reliable evidence for their traditional uses.
The only exception is Pumpkin extract, which shows possibly effective evidence for benign prostatic hyperplasia (enlarged prostate). For most of the conditions this blend might be marketed for, the science just isn't established in the data we hold.
How safe is it?
Well-documented data
Black Walnut Husk Extract is generally well tolerated short-term in oral form, though long-term use isn't well studied; the hull and leaf contain tannins that can cause stomach upset, and allergic reactions are possible in people sensitive to tree nuts. Cascara sagrada is generally well tolerated when used short-term, but long-term use carries real risks including low potassium and, rarely, liver damage.
Wormwood Aerial Part Extract contains thujone, a neurotoxin — short-term use of a properly prepared product may be acceptable, but the oil can cause muscle aches, nausea, vomiting, and in rare cases acute kidney damage or seizures. Pumpkin extract is generally well tolerated, though abdominal discomfort, diarrhea, nausea, and rarely severe allergic reaction (anaphylaxis) are possible.
Male Fern Root Extract is potentially toxic with a very narrow margin between an effective and poisonous dose — common side effects include stomach upset, headache, tremors, and dizziness, and serious toxicity can cause blindness, seizures, and death. Regarding pregnancy and breastfeeding: Black Walnut is possibly unsafe while nursing, and safety information isn't on file for pregnancy.
Cascara sagrada is not recommended during pregnancy or while nursing. Wormwood may stimulate the uterus and is unsafe in pregnancy; it should be avoided while breastfeeding.
Pumpkin as food is fine during pregnancy and nursing, but there isn't enough data on concentrated supplements. Male Fern is likely unsafe in pregnancy and should be avoided while breastfeeding.
Talk with your doctor or pharmacist if you are pregnant, planning pregnancy, or breastfeeding before taking this product.
Meds to double-check
Moderate interaction found
Check your medications against this product if you take corticosteroids, diuretics, blood thinners like warfarin (Coumadin), heart medications such as digoxin (Lanoxin), anticonvulsants (seizure drugs), or lithium. These are the drug types with documented Moderate-severity interactions.
Run your prescription names through the search tool on this page to be sure.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines five herbal ingredients with limited effectiveness evidence and significant safety and interaction concerns — especially Cascara sagrada, Wormwood, and Male Fern. If you take medications for your heart, seizures, blood pressure, blood clotting, or mental health, or if you take lithium, you need to check this against your exact prescription list before starting.
Talk with your pharmacist or doctor, particularly if you're pregnant, nursing, or planning to become pregnant.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about W-W, straight from the product label.
| Brand | Pure Herbs |
|---|---|
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2022 |
| DSLD ID | 280553 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for W-W by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1900 mg | -- |
| Black Walnut Husk Extract | 0 NP | -- |
| Cascara sagrada Bark Extract | 0 NP | -- |
| Wormwood Aerial Part Extract | 0 NP | -- |
| Pumpkin extract | 0 NP | -- |
| Male Fern Root Extract | 0 NP | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.
Shake well before use
Formulation
Beneficial for digestive health, occasional constipation and maintaining general overall health.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Notice: This product contains Cascara Sagrada. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stool, or abdominal pain because Cascara Sagrada may worsen these conditions and be harmful to your health. Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication or have a medical condition.
Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication or have a medical condition.
Keep out of reach of children
Contains: Walnuts
Brand IP Statement(s)
Pure Herbs, Ltd. Natural Herbal Extracts
FDA Statement of Identity
Dietary Supplement
General Statements
"No expense has been spared to provide the finest nature has to offer."
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
W-W by Pure Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in W-W by Pure Herbs
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
W-W by Pure Herbs Drug Interactions
HelloPharmacist Interaction Report
W-W by Pure Herbs is a liquid herbal blend with several ingredients that interact with medications.
The most serious concern is Cascara sagrada Bark Extract, which carries Moderate-severity interactions with a number of drug types including corticosteroids, diuretics, and the blood thinner warfarin (Coumadin). Cascara sagrada is a stimulant laxative, and long-term use can lower your potassium levels — a problem that gets worse if you're already taking drugs that deplete potassium or if you take the heart medication digoxin (Lanoxin), where low potassium raises toxicity risk.
It can also increase bleeding risk with warfarin by triggering diarrhea, which affects how your body processes the drug.
Read the full breakdown — every affected drug type, severity by severity
Wormwood Aerial Part Extract has a Moderate interaction with anticonvulsants (seizure medications), since one of its compounds may interfere with how well they work. Pumpkin extract carries a Moderate interaction with lithium; pumpkin's diuretic effect may reduce how much lithium your kidneys clear, raising its levels in your blood.
Black Walnut Husk Extract and Male Fern Root Extract show no interactions documented in our data; however, that is not a guarantee none exist. Altogether, these interactions span 777 individual medications.
Before you start this product, run your exact prescriptions through the checker on this page — especially if you take a diuretic, corticosteroid, blood thinner, seizure medication, heart drug, or lithium.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against W-W?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in W-W interact with 787 drugs. Click any drug to see the details.
3 of the 5 ingredients in W-W interact with drugs. Each result below shows which ingredient is responsible. Cascara sagrada Bark Extract Wormwood Aerial Part Extract Pumpkin extract
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with W-W — through 2 ingredients. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Acetazolamide interactionCascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Acetazolamide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Amiloride, Hydrochlorothiazide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Aminophylline, Amobarbital, Ephedrine interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Ammonium Chloride interactionAmobarbitalAmytal
How Amobarbital interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Amobarbital, Secobarbital interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Aprobarbital, Butabarbital, Phenobarbital interactionArmodafinilNuvigil
How Armodafinil interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractStimulant Laxatives, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Read the full Cascara Sagrada Bark Extract + Armodafinil interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Atenolol, Chlorthalidone interactionAzelastine Hydrochloride, Fluticasone PropionateDymista
How Azelastine Hydrochloride, Fluticasone Propionate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Azelastine Hydrochloride, Fluticasone Propionate interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Azilsartan, Chlorthalidone interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Corticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Beclomethasone Dipropionate interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with W-W — through 2 ingredients. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionCascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Belladonna, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with W-W — through 2 ingredients. Tap an ingredient for the detail:
Wormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionCascara Sagrada Bark ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
Read the full Cascara Sagrada Bark Extract + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada Bark Extract + Benzthiazide interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with W-W — through 1 ingredient. Tap an ingredient for the detail:
Cascara Sagrada Bark ExtractCorticosteroids Moderate
Interaction Summary
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Read the full Cascara Sagrada Bark Extract + Betamethasone Dipropionate, Calcipotriene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in W-W with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cascara sagrada Bark Extract
Corticosteroids
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Digoxin (Lanoxin)
Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Diuretic Drugs
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.
Stimulant Laxatives
Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.
Warfarin (Coumadin)
Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Wormwood Aerial Part Extract
Anticonvulsants
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Thujone, a constituent of wormwood, has convulsant effects.
Pumpkin extract
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for W-W, from the product label.
Pure Herbs
See all Pure Herbs products- Name
- Pure Herbs, Ltd.
- City
- Sterling Heights
- State
- MI
- Phone Number
- (800) 860-4372
- Web Address
- www.pureherbs.com
W-W by Pure Herbs: Common Questions
Does W-W by Pure Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this product safe to take while I'm pregnant?
Can I take this while breastfeeding?
What does Male Fern Root Extract do in this blend?
Does Cascara sagrada really help constipation?
Why does Pumpkin extract interact with lithium?
What's the side effect I'm most likely to notice?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind W-W’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Black Walnut
Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...
Read the full Black Walnut monograph → Herb & supplement monographCascara Sagrada
Interacts with 745 drugsCascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...
Read the full Cascara Sagrada monograph → Herb & supplement monographWormwood
Interacts with 50 drugsWormwood is a very bitter herb traditionally used to stimulate appetite and ease digestion, and it has early research interest in Crohn's disease. It contains thujone, which can be toxic in...
Read the full Wormwood monograph → Herb & supplement monographPumpkin
Interacts with 1 drugPumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...
Read the full Pumpkin monograph → Herb & supplement monographMale Fern
Male fern is an old herbal remedy that was once used as a powerful treatment to expel tapeworms. It is now considered outdated and potentially dangerous because of its narrow safety margin a...
Read the full Male Fern monograph →Sources & How We Checked
W-W's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Black Walnut 3 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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