Salacia Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Salacia interacts with medications. The heart of this page is the interaction list — every drug Salacia is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Salacia is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Salacia against your medication
Add one medicationSalacia Drug Interactions: The Bottom Line
From the HelloPharmacist Editorial Team · Updated July 2026Based on the available evidence, the overall risk of a clinically significant Salacia drug interaction appears low for most people, with the real concern limited to medicines that lower blood sugar. None of the listed interactions are rated major, and every single one comes down to the same issue: Salacia's own blood-sugar-lowering effect.
The interaction that matters is with diabetes medications, including insulin and blood-sugar-lowering pills. Human research suggests Salacia can lower blood glucose on its own, so adding it to these drugs could push blood sugar too low and cause hypoglycemia. Because blood sugar is a closely watched, narrow-margin target, this pairing deserves careful attention even though it is rated moderate rather than major. This is the best-documented concern in Salacia's profile, supported by human data rather than lab theory alone.
The list of interacting medications looks long, but it does not represent dozens of separate problems. It reflects one effect, lower blood sugar, counted across the many individual diabetes drugs on the market. For people who do not take blood-sugar-lowering medicines, no other documented interactions stand out in the data we have.
Based on HelloPharmacist’s Salacia interaction data and reviewed under our editorial standards.
Drugs that interact with Salacia
86 medications have a known interaction with Salacia, graded by severity. Select any drug for the full evidence-based detail.
Don’t want to scroll the list? Just ask.
Tell us the medications you take and we’ll check each one against Salacia using our pharmacist-reviewed interaction data.
AI summaries are generated from our Salacia interaction data for education only — always confirm with your pharmacist. How we use AI
No drugs match “”.
AcarboseGlucobay, Prandase, Precose
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Acarbose interaction Acarbose drug page: uses, dosage & side effectsAcetohexamideDymelor
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Acetohexamide interactionAlbiglutideTanzeum
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Albiglutide interactionAlogliptinNesina
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Alogliptin interaction Alogliptin drug page: uses, dosage & side effectsAlogliptin, MetforminKazano
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Alogliptin, Pioglitazone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Canagliflozin interaction Canagliflozin drug page: uses, dosage & side effectsCanagliflozin, MetforminInvokamet
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Chlorpropamide interactionDapagliflozinFarxiga
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Dapagliflozin interaction Dapagliflozin drug page: uses, dosage & side effectsDapagliflozin Propanediol, MetforminXigduo XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Dasiglucagon Hydrochloride interaction Dasiglucagon Hydrochloride drug page: uses, dosage & side effectsDulaglutideTrulicity
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Dulaglutide interaction Dulaglutide drug page: uses, dosage & side effectsEmpagliflozinJardiance
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Empagliflozin interaction Empagliflozin drug page: uses, dosage & side effectsEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Ertugliflozin interaction Ertugliflozin drug page: uses, dosage & side effectsErtugliflozin, Metformin HydrochlorideSegluromet
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Exenatide interaction Exenatide drug page: uses, dosage & side effectsExenatide SyntheticBydureon BCISE
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Exenatide Synthetic interaction Exenatide Synthetic drug page: uses, dosage & side effectsGliclazideDiamicron
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Gliclazide interactionGlimepirideAmaryl
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Glimepiride interaction Glimepiride drug page: uses, dosage & side effectsGlipizideGlucotrol, Glucotrol XL
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Glipizide interaction Glipizide drug page: uses, dosage & side effectsGlipizide, MetforminMetaglip
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Glipizide, Metformin interactionGlucagonBaqsimi, Glucagon
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Glucagon interaction Glucagon drug page: uses, dosage & side effectsGlucoseIV Glucose
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Glucose interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Glyburide interaction Glyburide drug page: uses, dosage & side effectsGlyburide, MetforminGlucovance
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Glyburide, Metformin interactionInhaled InsulinExubera
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Inhaled Insulin interactionInsulinNovoRapid Insulin
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin interactionInsulin (bovine)Hypurin Bovine Neutral
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin (bovine) interactionInsulin (human)Afrezza, Novolin 70/30, Novolin L, Novolin N, Novolin R
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin (human) interaction Insulin (human) drug page: uses, dosage & side effectsInsulin (pork)Hypurin Porcine Neutral, Lente Iletin II, NPH Iletin, NPH Iletin II, Pork Actrapid, Regular Iletin +1 more
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin (pork) interactionInsulin (rdna)Actrapid, Humalog, Humalog Mix 75/25, Humulin 50/50, Humulin 70/30, Humulin L +8 more
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin (rdna) interaction Insulin (rdna) drug page: uses, dosage & side effectsInsulin AspartFiasp
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Aspart interaction Insulin Aspart drug page: uses, dosage & side effectsInsulin Aspart, Insulin DegludecRyzodeg 70/30
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Aspart, Insulin Degludec interactionInsulin DegludecTresiba
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Degludec interaction Insulin Degludec drug page: uses, dosage & side effectsInsulin Degludec, LiraglutideXultophy 100/3.6
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Degludec, Liraglutide interactionInsulin GlargineBasaglar, Lusduna, Semglee
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Glargine interaction Insulin Glargine drug page: uses, dosage & side effectsInsulin Glargine (rdna)Lantus
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Glargine (rdna) interaction Insulin Glargine (rdna) drug page: uses, dosage & side effectsInsulin Glargine RecombinantToujeo Solostar
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Glargine Recombinant interactionInsulin Glargine, LixisenatideSoliqua 100/33
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Glargine, Lixisenatide interactionInsulin Glulisine (rdna)Apidra
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Glulisine (rdna) interaction Insulin Glulisine (rdna) drug page: uses, dosage & side effectsInsulin Human, Sodium ChlorideMyxredlin
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Human, Sodium Chloride interaction Insulin Human, Sodium Chloride drug page: uses, dosage & side effectsInsulin LisproAdmelog, Admelog Solostar
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Lispro interaction Insulin Lispro drug page: uses, dosage & side effectsInsulin Lispro RecombinantHumalog Kwikpen
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Lispro Recombinant interactionInsulin Lispro-aabcLyumjev
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Lispro-aabc interactionInsulin DetermirLevemir
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Insulin Determir interaction Insulin Determir drug page: uses, dosage & side effectsLinagliptinTradjenta
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Linagliptin interaction Linagliptin drug page: uses, dosage & side effectsLinagliptin, Metformin HydrochlorideJentadueto XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Linagliptin, Metformin Hydrochloride interactionLiraglutideVictoza
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Liraglutide interaction Liraglutide drug page: uses, dosage & side effectsLiraglutide RecombinantSaxenda
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Liraglutide Recombinant interaction Liraglutide Recombinant drug page: uses, dosage & side effectsLixisenatideAdlyxin
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Lixisenatide interaction Lixisenatide drug page: uses, dosage & side effectsMetforminGlucophage, Metformin
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Metformin interaction Metformin drug page: uses, dosage & side effectsMetformin HydrochlorideRiomet ER
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Metformin Hydrochloride interactionMetformin XrGlucophage XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Metformin Xr interactionMetformin, LinagliptinJentadueto
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Metformin, Sitagliptin interactionMiglitolGlyset
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Miglitol interaction Miglitol drug page: uses, dosage & side effectsMuraglitazarPargluva
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Muraglitazar interactionNateglinideStarlix
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Nateglinide interaction Nateglinide drug page: uses, dosage & side effectsPioglitazoneActos
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Pioglitazone interaction Pioglitazone drug page: uses, dosage & side effectsPramlintideSymlin
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Pramlintide interaction Pramlintide drug page: uses, dosage & side effectsRepaglinideGlucoNorm, Prandin
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Repaglinide interaction Repaglinide drug page: uses, dosage & side effectsRosiglitazone MaleateAvandia
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Rosiglitazone Maleate interaction Rosiglitazone Maleate drug page: uses, dosage & side effectsSaxagliptinOnglyza
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Saxagliptin interaction Saxagliptin drug page: uses, dosage & side effectsSaxagliptin, Metformin XrKombiglyze
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Saxagliptin, Metformin Xr interactionSemaglutideOzempic, Rybelsus, Wegovy
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Semaglutide interaction Semaglutide drug page: uses, dosage & side effectsSimvastatin, SitagliptinJuvisync
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Simvastatin, Sitagliptin interactionSitagliptinJanuvia, Zituvio
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Sitagliptin interaction Sitagliptin drug page: uses, dosage & side effectsSitagliptin, MetforminZituvimet
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Sitagliptin, Metformin interactionSotagliflozinInpefa
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Sotagliflozin interactionTirzepatideMounjaro, Zepbound
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Tirzepatide interaction Tirzepatide drug page: uses, dosage & side effectsTobutamideMobenol
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Tobutamide interactionTolazamideTolinase
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Tolazamide interaction Tolazamide drug page: uses, dosage & side effectsTolbutamideOrinase
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Tolbutamide interaction Tolbutamide drug page: uses, dosage & side effectsTroglitazoneRezulin
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Troglitazone interactionVildagliptinGalvus
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Vildagliptin interactionPioglitazone, MetforminActoPlus Met
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Pioglitazone, Metformin interactionRosiglitazone, GlimepirideAvandaryl
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Salacia + Rosiglitazone, Glimepiride interactionWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Salacia combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The kinds of drugs Salacia affects
Every type of medication (drug category) Salacia is known to interact with. Open any category for the detail — or search your exact drug in the checker above.
Antidiabetes Drugs
Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research suggests that salacia might lower blood glucose levels.
Salacia: Uses, Safety & Side Effects
Salacia is a plant used in Ayurvedic medicine, mostly studied for lowering blood sugar after meals. Some small human studies suggest it may modestly blunt blood sugar spikes, but the evidence is limited and far from conclusive. If you have diabetes or take other medicines, talk with your pharmacist or doctor before using it.

- Scientific name
- Salacia oblonga
- Family
- Celastraceae
- Part used
- Root and stem (root bark and wood)
- Common forms
- Capsules, tablets, powders, standardized extracts, teas
- Blood sugar control
- Type 2 diabetes support
- Weight management
- Obesity
- Traditional Ayurvedic remedy
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally seems well tolerated short-term, but long-term safety is not well studied.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Salacia is a woody climbing plant used for a long time in traditional Ayurvedic medicine. Several related species are used, including Salacia oblonga, Salacia reticulata, and Salacia chinensis. These plants grow in tropical parts of Asia, including India, Sri Lanka, and Thailand.
The root and stem are the parts most often used. They are dried and made into powders, capsules, tablets, or teas. Some products use standardized extracts that aim to contain set amounts of natural compounds found in the plant.
Most people take Salacia hoping to help control blood sugar or support weight loss. It is also used in traditional medicine for inflammation and digestive complaints.
How it works
Salacia contains natural compounds such as salacinol, kotalanol, and mangiferin. Salacinol and similar compounds are thought to block a gut enzyme called alpha-glucosidase. This enzyme helps break down complex carbohydrates into sugar.
By slowing this breakdown, less sugar may be absorbed quickly after a meal, which could blunt the spike in blood sugar. This is a similar idea to how some prescription diabetes drugs work.
Mangiferin and other plant compounds have shown antioxidant and anti-inflammatory effects in laboratory studies. It is important to know that much of this mechanism research comes from test-tube and animal studies, which do not always predict what happens in people.
Does Salacia work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Salacia, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Diabetes
Small clinical studies suggest that oral salacia might improve glycemic control in patients with type 2 diabetes.
Insufficient Reliable Evidence To Rate Obesity
Although there has been interest in using oral salacia for obesity, there is insufficient reliable information about the clinical effects of salacia for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
In short-term studies, Salacia appears to be reasonably well tolerated by most healthy adults. However, its long-term safety has not been well studied, and quality can vary a lot between supplement brands.
People with diabetes should be careful, since Salacia may lower blood sugar and could add to the effect of other blood-sugar-lowering treatments. Always monitor your blood sugar and work with your healthcare team.
Because there is not enough reliable safety information, pregnant and breastfeeding people should avoid Salacia. Children and people with serious health conditions should also avoid it unless a doctor advises otherwise. As with any supplement, talk with your pharmacist or doctor before starting.
Side effects
The most commonly reported side effects are digestive, such as gas, bloating, stomach discomfort, nausea, or loose stools. This may be linked to how it slows carbohydrate breakdown in the gut.
Because Salacia may lower blood sugar, there is a possible risk of blood sugar dropping too low (hypoglycemia), especially if combined with other treatments that lower blood sugar. Watch for symptoms like shakiness, sweating, or confusion.
Serious side effects have not been clearly documented, but this may be because long-term and large studies are lacking. Stop using it and seek medical advice if you have an unusual or severe reaction.
Salacia: Reported Adverse Effects
Documented safety reports on Salacia from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, salacia seems to be well tolerated.
Most Common Adverse Effects:
Orally: Abdominal pain, diarrhea, dyspepsia, flatulence, nausea.
Diarrhea Gastrointestinal
Orally, salacia can cause flatulence, distention, belching, abdominal pain, nausea, and diarrhea. These side effects seem to be dose-dependent. Drinking salacia tea can cause dyspepsia and loose stools. These gastrointestinal side effects are due to the fermentation of undigested carbohydrates in the bowel.
- Heacock PM, Hertzler SR, Williams JA, Wolf BW. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J Am Diet Assoc 2005;105:65-71.
- Collene AL, Hertzler SR, Williams JA, Wolf BW. Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults. Nutrition 2005;21:8
- Williams JA, Choe YS, Noss MJ, et al. Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes. Am J Clin Nutr 2007;86:124-30.
- Jayawardena MH, de Alwis NM, Hettigoda V, Fernando DJ. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. J Ethnopharmacol 2005;97:215-8.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official, well-established standard dose for Salacia. Studies have used different plant species, different extracts, and different amounts, which makes it hard to give one reliable recommendation.
If you choose to use a Salacia product, follow the directions on the label and do not exceed the suggested amount. Products meant to support blood sugar are often taken with or just before meals.
Because strength and quality differ between brands, it is a good idea to choose products that are independently tested and to check with your pharmacist or doctor before starting, especially if you have diabetes.
Salacia & Pregnancy
Salacia & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 5 references that drive our Salacia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Heacock PM, Hertzler SR, Williams JA, Wolf BW. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J Am Diet Assoc 2005;105:65-71.
- Collene AL, Hertzler SR, Williams JA, Wolf BW. Effects of a nutritional supplement containing Salacia oblonga extract and insulinogenic amino acids on postprandial glycemia, insulinemia, and breath hydrogen responses in healthy adults. Nutrition 2005;21:8 PubMed
- Jayawardena MH, de Alwis NM, Hettigoda V, Fernando DJ. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. J Ethnopharmacol 2005;97:215-8. PubMed
- Williams JA, Choe YS, Noss MJ, et al. Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes. Am J Clin Nutr 2007;86:124-30. PubMed
- Kajimoto O, Kawamori S, Shimoda H, et al. Effects of a Diet Containing Salacia reticulata on Mild Type 2 Diabetes in Humans. A Placebo-controlled, Cross-over Trial. Nippon Eiyo Shokuryo Gakkaishi 2000;53(5):199-205. DOI
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Salacia
20 brands in our database make a supplement containing Salacia.
Supplement products with Salacia
34 products in our database contain Salacia. Open any to see its full ingredient list and every drug interaction we check.
Salacia: Common Questions
What is Salacia used for, and does it work?
Does Salacia interact with prescription medications?
How are Salacia interactions rated?
Is it safe to take Salacia with my medications?
Where does this Salacia interaction information come from?
What is Salacia used for?
Does Salacia really lower blood sugar?
Is Salacia safe to take?
Can I take Salacia if I am pregnant or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Salacia
A rotating sample of real supplements in our database that list Salacia — open any to see its full ingredients and every drug interaction we check.
- Slim 700 by S4L Slim4Life
- Clinical Strength Thermal XTC by Nutrabolics
- Glycoscia by Genoma Nutritionals
- Glycemic Select by Moss Nutrition
- Levolar Forte by Aloha Medicinals
- LeanWorx by SuperiorLabs
- Never-Say-Die Powder by Ron Teeguarden's Dragon Herbs
- Glycemic Select by Moss Nutrition
- Salacia 500 mg by Ron Teeguarden's Dragon Herbs
- Gluco Calm by Peak Biome
Have a question about Salacia?
Our pharmacists answer your medication & supplement questions — free.