Herb & supplement monograph

Inositol Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines

Inositol Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Inositol drug interaction appears low for most people, unless you take medication for diabetes. None of the listed interactions are rated major, and every one of them traces back to a single concern: inositol's effect on blood sugar.

Interactions deserving the most attention

The medications that deserve real attention here are diabetes medications. Clinical research in people shows inositol can lower blood glucose and HbA1c levels, so adding it to insulin or other glucose-lowering drugs could, in theory, push blood sugar too low. That additive low-blood-sugar effect has not been proven in studies, but because blood sugar is closely monitored and the stakes of going too low are real, this combination is worth taking seriously. Nothing else in the profile stands out.

What the rest of the list means

The number of interacting medications may look long, but it is misleading on its own. Every entry is a diabetes medicine flagged for the same reason, not dozens of separate problems. The concern is a predicted additive effect on blood sugar rather than a harmful reaction documented in people taking the combination.

Check your medications against Inositol

Based on HelloPharmacist’s Inositol interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Inositol

86 medications have a known interaction with Inositol, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Acetohexamide interaction
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Albiglutide interaction
AlogliptinNesina
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Alogliptin, Pioglitazone interaction
Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interaction
CanagliflozinInvokana
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Canagliflozin interaction Canagliflozin drug page: uses, dosage & side effects
Canagliflozin, MetforminInvokamet
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Canagliflozin, Metformin interaction
Canagliflozin, Metformin HydrochlorideInvokamet XR
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Canagliflozin, Metformin Hydrochloride interaction
ChlorpropamideChlorpropam, Diabinese
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Chlorpropamide interaction
DapagliflozinFarxiga
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Dapagliflozin interaction Dapagliflozin drug page: uses, dosage & side effects
Dapagliflozin Propanediol, MetforminXigduo XR
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Dapagliflozin Propanediol, Metformin interaction
Dapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interaction
Dapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interaction
Dasiglucagon HydrochlorideZegalogue
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Dasiglucagon Hydrochloride interaction Dasiglucagon Hydrochloride drug page: uses, dosage & side effects
DulaglutideTrulicity
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Dulaglutide interaction Dulaglutide drug page: uses, dosage & side effects
EmpagliflozinJardiance
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Empagliflozin interaction Empagliflozin drug page: uses, dosage & side effects
Empagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Empagliflozin, Linagliptin, Metformin Hydrochloride interaction
Empagliflozin, MetforminSynjardy
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Empagliflozin, Metformin interaction
Empagliflozin, Metformin HydrochlorideSynjardy XR
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Empagliflozin, Metformin Hydrochloride interaction
ErtugliflozinSteglatro
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Ertugliflozin interaction Ertugliflozin drug page: uses, dosage & side effects
Ertugliflozin, Metformin HydrochlorideSegluromet
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Ertugliflozin, Metformin Hydrochloride interaction
ExenatideBydureon, Byetta
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Exenatide interaction Exenatide drug page: uses, dosage & side effects
Exenatide SyntheticBydureon BCISE
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Exenatide Synthetic interaction Exenatide Synthetic drug page: uses, dosage & side effects
GliclazideDiamicron
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Gliclazide interaction
GlimepirideAmaryl
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Glimepiride interaction Glimepiride drug page: uses, dosage & side effects
GlipizideGlucotrol, Glucotrol XL
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Glipizide interaction Glipizide drug page: uses, dosage & side effects
Glipizide, MetforminMetaglip
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Glipizide, Metformin interaction
GlucagonBaqsimi, Glucagon
Moderate Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Inositol + Glucagon interaction Glucagon drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Inositol combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Inositol affects

Every type of medication (drug category) Inositol is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Inositol interacts with
Antidiabetes Drugs
Antidiabetes Drugs

Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that inositol lowers blood glucose levels and glycated hemoglobin (HbA1c) levels in patients with diabetes.

Likelihood Possible Evidence A
Monograph

Inositol: Uses, Safety & Side Effects

The bottom line

Inositol is a sugar alcohol made naturally in the body and found in many foods, and it is sold as a supplement (often myo-inositol) mainly for PCOS, mood, and metabolic concerns. The strongest evidence is for PCOS-related symptoms, while support for other uses is more limited. It is generally well tolerated, but talk with your pharmacist or doctor before starting it, especially if you are pregnant or have a health condition.

Inositol
Part used
Not applicable (a sugar alcohol found in foods and made by the body)
Common forms
Capsules, tablets, powder (often as myo-inositol or D-chiro-inositol)
People commonly use it for
  • Polycystic ovary syndrome (PCOS)
  • Anxiety and panic
  • Depression and mood
  • Insulin and blood sugar support
  • Fertility support
  • Metabolic syndrome

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

Generally well tolerated at common doses, with mostly mild digestive side effects.

PregnancyPossibly Safe

When used orally and appropriately, short-term. Myo-inositol has been used with apparent safety in amounts up to 4000 mg daily during pregnancy.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using. Breast milk is rich in endogenous inositol; however, the effects of exogenously administered...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Inositol is a type of carbohydrate often called a sugar alcohol. It is sometimes nicknamed "vitamin B8," but it is not a true essential vitamin because your body can make it on its own. It is also found naturally in foods like fruits, beans, grains, and nuts.

There are several forms of inositol. The two most common in supplements are myo-inositol and D-chiro-inositol. Some products combine the two in a specific ratio.

People take inositol supplements for a range of reasons, most commonly for polycystic ovary syndrome (PCOS), mood and anxiety concerns, and blood sugar or metabolic support.

How it works

Inositol acts as a building block for "second messengers" — molecules inside cells that help carry signals from hormones like insulin. By supporting these signaling pathways, inositol is thought to influence how the body responds to insulin and how certain brain chemicals work.

This is one reason it has been studied for both blood sugar and mood. Much of the detailed mechanism comes from laboratory and animal research, so exactly how it produces effects in people is still being studied.

Effectiveness

Does Inositol work?

Evidence overview · 28 uses evaluated
3 Possibly effective 5 Leans ineffective 20 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Metabolic syndrome
Rating & evidence shown verbatim from Natural Medicines

Oral inositol seems to modestly improve lipid parameters, blood pressure, and insulin resistance in patients with metabolic syndrome.

Possibly Effective Polycystic ovary syndrome (PCOS)
Rating & evidence shown verbatim from Natural Medicines

Oral inositol, often in combination with folic acid, seems to improve some glycemic, lipid, metabolic, hormonal, and reproductive parameters in patients with PCOS. However, research is conflicting.

Possibly Effective Preterm labor
Rating & evidence shown verbatim from Natural Medicines

Oral inositol in combination with folic acid seems to prevent preterm labor in individuals at risk for gestational diabetes.

Possibly Ineffective Acute respiratory distress syndrome (ARDS)
Rating & evidence shown verbatim from Natural Medicines

Oral or intravenous inositol does not seem to prevent ARDS in preterm infants and may be associated with worsened outcomes.

Possibly Ineffective Anxiety
Rating & evidence shown verbatim from Natural Medicines

Oral inositol does not seem to be beneficial for patients with anxiety.

Possibly Ineffective Depression
Rating & evidence shown verbatim from Natural Medicines

Oral inositol does not seem to be beneficial for patients with depression.

Possibly Ineffective Diabetic neuropathy
Rating & evidence shown verbatim from Natural Medicines

Oral inositol does not seem to be beneficial for patients with diabetic neuropathy.

Possibly Ineffective Retinopathy of prematurity
Rating & evidence shown verbatim from Natural Medicines

Oral or intravenous inositol does not seem to prevent retinopathy of prematurity (ROP) in preterm infants.

Also studied for 20 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related testosterone deficiency
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral D-chiro-inositol is beneficial in patients with age-related testosterone deficiency.

Insufficient Reliable Evidence To Rate Bipolar disorder
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial in patients with bipolar disorder.

Insufficient Reliable Evidence To Rate Chemotherapy-induced leukopenia
Rating & evidence shown verbatim from Natural Medicines

Oral inositol has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial for the treatment of type 1 diabetes or the prevention of gestational diabetes.

Insufficient Reliable Evidence To Rate Dyslipidemia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol for hypercholesterolemia and hypertriglyceridemia, there is insufficient reliable information about the clinical effects of inositol for these conditions.

Insufficient Reliable Evidence To Rate Erectile dysfunction (ED)
Rating & evidence shown verbatim from Natural Medicines

Oral inositol has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral inositol for hypertension, there is insufficient reliable information about the clinical effects of inositol for this condition.

Insufficient Reliable Evidence To Rate Hypothyroidism
Rating & evidence shown verbatim from Natural Medicines

Inositol has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Infertility
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial in patients undergoing intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF).

Insufficient Reliable Evidence To Rate Insomnia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial for improving sleep during pregnancy.

Insufficient Reliable Evidence To Rate Lithium-induced side effects
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial for reducing lithium-induced side effects.

Insufficient Reliable Evidence To Rate Lung cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial for slowing the rate of bronchial dysplasia.

Insufficient Reliable Evidence To Rate Nonalcoholic fatty liver disease (NAFLD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial for NAFLD.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial in patients with overweight or obesity.

Insufficient Reliable Evidence To Rate Obsessive-compulsive disorder (OCD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial in patients with OCD.

Insufficient Reliable Evidence To Rate Panic disorder
Rating & evidence shown verbatim from Natural Medicines

Oral inositol seems to improve symptoms of panic disorder.

Insufficient Reliable Evidence To Rate Post-traumatic stress disorder (PTSD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial in patients with PTSD.

Insufficient Reliable Evidence To Rate Pregnancy-induced hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial for preventing hypertension during pregnancy.

Insufficient Reliable Evidence To Rate Psoriasis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral or topical inositol is beneficial for improving symptoms of psoriasis.

Insufficient Reliable Evidence To Rate Trichotillomania
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral inositol is beneficial for reducing hair pulling.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Inositol is generally considered safe and well tolerated for most adults at commonly used doses. Because it can affect insulin and blood sugar signaling, people with diabetes or blood sugar problems should monitor closely and talk with their healthcare provider.

Pregnancy: Inositol has sometimes been studied during pregnancy, but its safety is not fully established. Use it only if your doctor recommends it.

Breastfeeding: There is not enough reliable information about using inositol supplements while breastfeeding, so caution is advised.

As with any supplement, choose reputable brands, and let your pharmacist or doctor know what you are taking, especially if you have an existing health condition.

Side effects

Inositol is usually well tolerated. When side effects occur, they are typically mild and most often involve the digestive system, such as nausea, gas, bloating, stomach upset, or diarrhea. These are more likely at higher doses.

Some people report tiredness, headache, or dizziness. Serious side effects are uncommon, but stop using it and seek care if you have a severe or allergic reaction.

Inositol: Reported Adverse Effects

Documented safety reports on Inositol from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally and intravenously, inositol seems to be well tolerated. Topically, no adverse effects have been reported, although a thorough evaluation of safety outcomes has not been conducted.

Most Common Adverse Effects:

Orally: Diarrhea, gas, and nausea.

Reports by condition
Allergic rhinitis (hay fever) Immunologic
Bipolar disorder Psychiatric

In one case report, a 36-year-old male with adequately controlled bipolar disorder was hospitalized with symptoms of mania after consuming several cans of an energy drink containing inositol, caffeine, taurine, and other ingredients (Red Bull Energy Drink) over a period of 4 days. It is not known if this is related to inositol, caffeine, taurine, a different ingredient, or a combination of the ingredients.

  1. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5.
Cluster headache Neurologic/CNS
Diarrhea Gastrointestinal
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official or standardized dose of inositol for general health. Studies have used a range of amounts depending on the form (myo-inositol versus D-chiro-inositol) and the reason for use.

Because the right amount can vary, it is best to follow the directions on your product label and check with a pharmacist or doctor before starting. Do not assume that higher doses are better or safer.

Pregnancy & Breastfeeding

Inositol & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using. Breast milk is rich in endogenous inositol; however, the effects of exogenously administered inositol are not known.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 14 references that drive our Inositol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol 2001;21:335-9.. PubMed
  2. Allan SJ, Kavanagh GM, Herd RM, Savin JA. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol 2004;150:966-9. PubMed
  3. Machado-Vieira R, Viale CI, Kapczinski F. Mania associated with an energy drink: the possible role of caffeine, taurine, and inositol. Can J Psychiatry 2001;46:454-5. PubMed
  4. Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD. Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 2015;31(2):131-5. PubMed
  5. Matarrelli B, Vitacolonna E, D'Angelo M, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med 2013;26(1 PubMed
  6. Mukai T, Kishi T, Matsuda Y, Iwata N. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol 2014;29(1):55-63. PubMed
  7. Farren M, Daly N, McKeating A, Kinsley B, Turner MJ, Daly S. The Prevention of Gestational Diabetes Mellitus With Antenatal Oral Inositol Supplementation: A Randomized Controlled Trial. Diabetes Care. 2017;40(6):759-63. PubMed
  8. Zheng X, Liu Z, Zhang Y, et al. Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore). 2015;94(42):e1604. PubMed
  9. Crawford TJ, Crowther CA, Alsweiler J, Brown J. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database Syst Rev. 2015;(12):CD011507. PubMed
  10. Maurizi AR, Menduni M, Del Toro R, et al. A pilot study of D-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetol. 2017;54(4):361-65. PubMed
  11. Leppink EW, Redden SA, Grant JE. A double-blind, placebo-controlled study of inositol in trichotillomania. Int Clin Psychopharmacol. 2017;32(2):107-14. PubMed
  12. Lam S, Mandrekar SJ, Gesthalter Y. A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia. Cancer Prev Res (Phila). 2016;9(12):906-14.
  13. Wozniak J, Faraone SV, Chan J, et al. A randomized clinical trial of high eicosapentaenoic acid omega-3 fatty acids and inositol as monotherapy and in combination in the treatment of pediatric bipolar spectrum disorders: a pilot study. J Clin Psychiatry. PubMed
  14. Vitale SG, Corrado F, Caruso S, et al. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes - a randomized and open-label, placebo-
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Inositol

10,343 products in our database contain Inositol. Open any to see its full ingredient list and every drug interaction we check.

+Mood Relief MoodLift Complex by Shaklee Capsule 120 Capsule(s) View ingredients & interactions 1 Activator by Systemic Formulas Bio Command Capsule 30 Capsule(s) View ingredients & interactions 1 Vitamin + Mineral by Pioneer Tablet Or Pill 120 Vegetarian Tablet(s) View ingredients & interactions 1 Week Flush by MH Michael's Health Naturopathic Programs Tablet Or Pill 84 Vegetarian Tablet(s) View ingredients & interactions 100% Organic Spirulina 500 mg by VitaCeutical Labs Tablet Or Pill 100 Vegetarian Tablet(s) View ingredients & interactions 100% Pure Inositol 500 Milligrams by NutraBio Capsule 120 V-Cap(s) View ingredients & interactions 100% Pure Inositol Powder by Swanson Premium Brand Powder 8 Ounce(s) · 227 Gram(s) View ingredients & interactions 100% Pure Stabilized Rice Bran by NutraBio Powder 600 Gram(s) · 21 oz. View ingredients & interactions 10X Life by Max Drive Nutrition Capsule 60 Capsule(s) View ingredients & interactions 10x Pure Ultimate Multi-Vitamin & Mineral Supplement by CTFO Changing The Future Outcome Capsule 60 Capsule(s) View ingredients & interactions 24K by Reliv Liquid 30 fl. Oz. · 1 pt. · 14 fl. Oz. · 887 mL View ingredients & interactions 24K by Reliv Powder 10.6 Ounce(s) View ingredients & interactions 24K Mixed Berry Flavor by Reliv Powder 10.6 Ounce(s) View ingredients & interactions 3 en 1 by Bellodec-tta Tablet Or Pill 60 Tablet(s) View ingredients & interactions 30 Day Beauty Regimen by Bronson Tablet Or Pill 30 Packet(s) View ingredients & interactions 3D Energy Drink Grape by 3D Energy Drinks Liquid 16 Fluid Ounce(s) · 473 mL · 1 Pint(s) View ingredients & interactions 3D Energy Drink Liberty Pop by 3D Energy Drinks Liquid 16 Fluid Ounce(s) · 473 mL · 1 Pint(s) View ingredients & interactions 3D Energy Drink Pina Colada by 3D Energy Drinks Liquid 16 Fluid Ounce(s) · 473 mL · 1 Pint(s) View ingredients & interactions 3D Energy Drink Sunburst by 3D Energy Drinks Liquid 16 Fluid Ounce(s) · 473 mL · 1 Pint(s) View ingredients & interactions 5-HTP (5-Hydroxytryptophan) 200 mg by Protocol For Life Balance Capsule 60 Veg Capsule(s) View ingredients & interactions 5-HTP Plus by Natrol Tablet Or Pill 150 Tablet(s) View ingredients & interactions 5-HTP+Complex with Ashwagandha & L-Taurine by Purely Optimal Capsule 60 Veggie Capsule(s) View ingredients & interactions 5-Hydroxy Gaba by Priority One Nutritional Supplements Capsule 90 Vegetarian Capsule(s) View ingredients & interactions 5-Hydroxy Gaba by Priority One Nutritional Supplements Capsule 45 Vegetarian Capsule(s) View ingredients & interactions
Drug-induced depletion

Medications associated with Inositol depletion

4 medications in our licensed clinical database have been associated with lower Inositol levels. An association is not a guarantee — it is a talking point for your pharmacist.

See all medications that may deplete Inositol

Pharmacist Counseling Corner

Inositol: Common Questions

What is Inositol used for, and does it work?
People use Inositol for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Inositol for Metabolic syndrome, Polycystic ovary syndrome (PCOS) and Preterm labor. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Inositol interact with prescription medications?
Yes. We list 86 medications with a known interaction with Inositol. Use the checker above to see how Inositol interacts with a specific drug.
How are Inositol interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Inositol with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Inositol interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Inositol most commonly used for?
It is most often used as a supplement for PCOS, as well as for anxiety, mood, and blood sugar or metabolic support. The strongest evidence is for PCOS-related symptoms.
Is Inositol a vitamin?
It is sometimes called "vitamin B8," but it is not a true essential vitamin because your body can make it on its own and it is found in many foods.
Is Inositol safe to take?
For most adults it is generally well tolerated, with mild digestive upset being the most common side effect. Still, check with your pharmacist or doctor, especially if you are pregnant, breastfeeding, or have a health condition.
What is the difference between myo-Inositol and D-chiro-Inositol?
These are two related forms of Inositol that work in slightly different ways in the body. Myo-Inositol is the most studied form, and some products combine both in a set ratio.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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