Herb & supplement monograph

Wheatgrass Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Wheatgrass interacts with medications. The heart of this page is the interaction list — every drug Wheatgrass is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Wheatgrass is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Wheatgrass Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Wheatgrass drug interaction appears low for most people, because every reported interaction is theoretical rather than proven in humans. None of the listed interactions are rated major, and all of them rest on animal or lab research only, not on human studies.

Interactions deserving the most attention

The combination most worth watching involves diabetes medications. Animal research suggests wheatgrass may prompt the body to release more insulin and lower blood sugar, so adding it could, in theory, increase the chance of low blood sugar in people whose glucose is tightly managed. Wheatgrass may also speed up an enzyme the liver uses to clear certain medications, which could make those medicines slightly less effective, though this has only been seen in lab studies.

What the rest of the list means

The long list of medications comes almost entirely from that one enzyme effect, so a large number does not mean many separate dangers. Most of these combinations have never been shown to cause meaningful changes in people, and the concerns remain predictions rather than documented problems.

Check your medications against Wheatgrass

Based on HelloPharmacist’s Wheatgrass interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Wheatgrass

272 medications have a known interaction with Wheatgrass, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.

Read the full Wheatgrass + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen interaction Acetaminophen drug page: uses, dosage & side effects
Acetaminophen, AspirinGemnisyn
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Aspirin interaction
Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Aspirin, Caffeine interaction
Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction
Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Butalbital interaction
Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Butalbital, Caffeine interaction Acetaminophen, Butalbital, Caffeine drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Caffeine, IsomethepteneMigralam
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Caffeine, Isometheptene interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Acetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
Moderate Cytochrome P450 1a2 (cyp1a2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full Wheatgrass + Acetaminophen, Chlorzoxazone interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Wheatgrass combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Wheatgrass affects

Every type of medication (drug category) Wheatgrass is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Wheatgrass interacts with
Antidiabetes DrugsCytochrome P450 1a2 (cyp1a2) Substrates
Antidiabetes Drugs

Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.
Animal research shows that taking wheatgrass stimulates the release of insulin from beta-cells and lowers blood glucose.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that wheatgrass induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Monograph

Wheatgrass: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and plant nutrients. Solid scientific evidence for most health claims is limited, and it is best viewed as a nutritional add-on rather than a treatment. It is generally well tolerated, but people with celiac disease, wheat allergy, or who are pregnant should be cautious and check with a healthcare provider.

Wheatgrass
Scientific name
Triticum aestivum
Family
Poaceae
Part used
Young grass (leaves/shoots) of the wheat plant
Common forms
Fresh juice, powder, tablets, capsules, and added to smoothies or health drinks
People commonly use it for
  • General nutrition support
  • Digestive health
  • Antioxidant support
  • Energy and wellness
  • Arthritis symptoms
  • Detox or cleansing routines

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated as a food, but quality and contamination concerns mean caution is wise.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Wheatgrass is the young, green grass of the common wheat plant, Triticum aestivum. It is harvested while the grass is still very young and tender, before the plant forms grain. It can be grown indoors in trays or on farms in many parts of the world.

People most often take wheatgrass as a fresh-squeezed juice, a dried powder, or in tablet and capsule form. The powder is popular because it can be stirred into water, juice, or smoothies. Wheatgrass is marketed as a "superfood" and a concentrated source of vitamins, minerals, chlorophyll, and plant antioxidants.

How it works

Wheatgrass contains chlorophyll, vitamins (such as some B vitamins, vitamin C, and vitamin K), minerals, amino acids, and various plant antioxidants. Supporters believe these compounds give it antioxidant and anti-inflammatory effects.

In laboratory and animal research, antioxidant plant compounds may help neutralize unstable molecules called free radicals and calm certain inflammatory signals. However, these proposed mechanisms are based largely on test-tube and animal studies, and it is not clear how strongly they apply when a person drinks wheatgrass juice or takes the powder.

Effectiveness

Does Wheatgrass work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 17 uses evaluated
17 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Wheatgrass, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 17 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Benign prostatic hyperplasia (BPH)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for BPH, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Beta-thalassemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral wheatgrass is beneficial in patients with beta-thalassemia.

Insufficient Reliable Evidence To Rate Bronchitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for bronchitis, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for cancer, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Common cold
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for common cold, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for cough, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for diabetes, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Gout
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for gout, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Hypercholesterolemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral wheatgrass is beneficial in patients with hypercholesterolemia.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for hypertension, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Kidney stones (nephrolithiasis)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for nephrolithiasis, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Pharyngitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for pharyngitis, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Plantar heel pain
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical wheatgrass is beneficial in patients with plantar heel pain.

Insufficient Reliable Evidence To Rate Prostatitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for prostatitis, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Ulcerative colitis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral wheatgrass is beneficial in patients with ulcerative colitis.

Insufficient Reliable Evidence To Rate Urinary tract infections (UTIs)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for UTIs, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral wheatgrass for wound healing, there is insufficient reliable information about the clinical effects of wheatgrass for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy adults, wheatgrass is generally considered safe when taken in normal food-like amounts. Because it is often grown and consumed raw, there is a possible risk of contamination with bacteria or mold, so product quality and proper handling matter.

People with a wheat allergy should be cautious, as reactions are possible. Wheatgrass is harvested before the grain forms, so it usually contains little or no gluten, but cross-contamination can occur—people with celiac disease or gluten sensitivity should choose products clearly labeled and tested gluten-free, and check with their provider.

Because safety has not been established, pregnant and breastfeeding women should avoid wheatgrass unless their doctor approves. Always tell your pharmacist or doctor about any supplements you take, especially if you have a health condition or take medications.

Side effects

Wheatgrass is usually well tolerated. The most common complaints are mild and digestive, such as nausea, upset stomach, bloating, or loss of appetite, especially when first starting. Some people dislike its strong grassy taste, which can trigger gagging.

Headache is also reported by some users. Allergic reactions are possible, particularly in people sensitive to wheat or grasses; signs can include swelling, hives, or trouble breathing. Stop use and seek medical care if you have any signs of a serious allergic reaction.

Wheatgrass: Reported Adverse Effects

Documented safety reports on Wheatgrass from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, wheatgrass is generally well tolerated.

Most Common Adverse Effects:

Orally: Allergic reactions, anorexia, constipation, nausea.

Reports by condition
Allergic rhinitis (hay fever) Immunologic

Wheat can cause allergic reactions in sensitive individuals. Due to the prevalence of this allergy in the general population, wheat and wheat products, such as wheatgrass, are classified as major food allergens in the United States.

  1. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
Anorexia Gastrointestinal

Orally, wheatgrass may cause nausea, anorexia, and constipation.

  1. Ben-Arye E, Golden E, Wengrower D, et al. Wheat grass juice in the treatment of active distal ulcerative colitis a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002;4:444-9..
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or standardized dose for wheatgrass. Amounts vary widely between fresh juice, powder, and tablets, so the right amount depends on the specific product.

The safest approach is to follow the directions on the product label and start with a small amount to see how your body responds. If you are considering wheatgrass for a specific health concern, talk with your pharmacist or doctor first to make sure it is appropriate for you.

Pregnancy & Breastfeeding

Wheatgrass & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Wheatgrass & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 5 references that drive our Wheatgrass monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ben-Arye E, Golden E, Wengrower D, et al. Wheat grass juice in the treatment of active distal ulcerative colitis a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002;4:444-9.. PubMed
  2. Mohan Y, Jesuthankaraj GN1, Ramasamy Thangavelu N. Antidiabetic and antioxidant properties of Triticum aestivum in streptozotocin-induced diabetic rats. Adv Pharmacol Sci 2013;2013:716073.
  3. Shakya G, Randhi PK, Pajaniradje S, Mohankumar K, Rajagopalan R. Hypoglycaemic role of wheatgrass and its effect on carbohydrate metabolic enzymes in type II diabetic rats. Toxicol Ind Health 2016;32(6):1026-32. PubMed
  4. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
  5. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Wheatgrass

61 brands in our database make a supplement containing Wheatgrass.

Product directory

Supplement products with Wheatgrass

114 products in our database contain Wheatgrass. Open any to see its full ingredient list and every drug interaction we check.

AcaiCleanse Natural 10 Day Acai Berry Detox by Garden Greens Tablet Or Pill 120 Tablet(s) View ingredients & interactions Anti-Grey by Absonutrix Capsule 60 Capsule(s) View ingredients & interactions Begin Daily GI Primer by Nutrilite Powder 9 Ounce(s) · 255 Gram(s) View ingredients & interactions Bio-Diuretic by MBi Nutraceuticals Capsule 90 Capsule(s) View ingredients & interactions Bladder Support by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Bladder Support by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Collagen Protein Broth Curcumin Chili by FREZZOR Powder 500 Gram(s) View ingredients & interactions Colon Cleanser by Radiance Capsule 240 Capsule(s) View ingredients & interactions Couch by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Couch by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Daily Greens by Science Natural Supplements Powder 3.175 Ounce(s) · 90 Gram(s) View ingredients & interactions Dissolvable Plant Protein Packs French Vanilla by Vade Nutrition Powder 1.33 lb(s) · 603 Gram(s) View ingredients & interactions Dissolvable Plant Protein Packs Rich Chocolate by Vade Nutrition Powder 1.36 Pound(s) View ingredients & interactions Earth Source Multi-Nutrient by Solgar Tablet Or Pill 3 Tablet(s) View ingredients & interactions Easy Veggies by Codeage Instantfood Capsule 90 Capsule(s) View ingredients & interactions Energreen by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Energreen Alcohol Free by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Enhanced Energy Once Daily Whole Food Multivitamin by KAL Tablet Or Pill 60 Vegetarian Tablet(s) View ingredients & interactions Environmental Defense 1 by Priority One Nutritional Supplements Capsule 90 Vegetarian Capsule(s) View ingredients & interactions Everyday Greens by Banyan Botanicals Tablet Or Pill 90 Tablet(s) View ingredients & interactions Field of Greens Citrus Punch by Just Ripe Nutrition Powder 114.8 Gram(s) View ingredients & interactions G.F.S.-2000 Powder by Douglas Laboratories Powder 250 Gram(s) · 8.8 Ounce(s) View ingredients & interactions Gallbaldder Support Formula by Solaray Capsule 90 VegCap(s) View ingredients & interactions Glorious Morning by Norse Fitness Powder 390 Gram(s) View ingredients & interactions
Pharmacist Counseling Corner

Wheatgrass: Common Questions

What is Wheatgrass used for, and does it work?
People use Wheatgrass for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Wheatgrass interact with prescription medications?
Yes. We list 272 medications with a known interaction with Wheatgrass. Use the checker above to see how Wheatgrass interacts with a specific drug.
How are Wheatgrass interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Wheatgrass with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Wheatgrass interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Wheatgrass used for?
People most often use Wheatgrass as a nutrient-rich supplement for general wellness, digestion, energy, and antioxidant support. Strong scientific proof for treating specific diseases is lacking, so it is best seen as a dietary add-on.
Does Wheatgrass contain gluten?
Wheatgrass is harvested before the wheat grain forms, so it usually contains little or no gluten. However, cross-contamination is possible, so people with celiac disease should choose products tested and labeled gluten-free.
Is Wheatgrass safe to take every day?
Many healthy adults tolerate daily Wheatgrass without problems, though mild nausea or stomach upset can occur. Choose quality products, follow the label, and check with your pharmacist or doctor if you have a medical condition.
Can I take Wheatgrass while pregnant or breastfeeding?
There is not enough reliable safety information, and raw products may carry a contamination risk, so it is best to avoid Wheatgrass during pregnancy and breastfeeding unless your doctor approves.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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