Diltiazem

92 interactions 10 explained in plain English
Also sold as: Cardizem Cartia Dilt Diltzac Matzim Taztia Tiadylt Tiazac
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Diltiazem Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Diltiazem Abametapir Explained Increased exposure of CYP3A4 substrate Details Diltiazem Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Diltiazem Relugolix Orgovyx Explained Increased relugolix exposure Details Diltiazem Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Diltiazem Acalabrutinib Calquence Increased acalabrutinib exposure and increased risk of toxicity Details Diltiazem Apixaban Eliquis Explained Increased apixaban exposure and increased risk of bleeding Details Diltiazem Atenolol Tenormin Explained An increased risk of hypotension, bradycardia and slow AV conduction Details Diltiazem Avapritinib Ayvakit Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Diltiazem Acebutolol Sectral® An increased risk of hypotension, bradycardia and slow AV conduction Details Diltiazem Atorvastatin Atorvaliq Increased atorvastatin exposure, an increased risk of rhabdomyolysis and an increased dilTIAZem exposure Details Diltiazem Cariprazine Vraylar Explained Increased cariprazine and its major active metabolite (didesmethylcariprazine (DDCAR)) exposure Details Diltiazem Amlodipine Amvaz® Increased amLODIPine exposure and an increased risk of hypotension and edema Details Diltiazem Bedaquiline Sirturo Increased bedaquiline exposure Details Diltiazem Betaxolol Betoptic S An increased risk of hypotension, bradycardia and slow AV conduction Details Diltiazem Betaxolol Ophthalmic Betoptic® An increased risk of hypotension, bradycardia and slow AV conduction Details Diltiazem Bisoprolol Zebeta® An increased risk of hypotension, bradycardia and slow AV conduction Details Diltiazem Bosutinib Bosulif Increased bosutinib exposure Details Diltiazem Brexpiprazole Rexulti Increased brexpiprazole exposure Details Diltiazem Brigatinib Alunbrig Increased brigatinib exposure Details Diltiazem Budesonide Entocort Increased budesonide exposure Details Diltiazem Budesonide Nasal Spray Rhinocort Increased budesonide exposure Details Diltiazem Budesonide Oral Inhalation Pulmicort Increased budesonide exposure Details Diltiazem Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction and an increased risk of bradycardia and A... Details Diltiazem Clopidogrel Plavix Decreased antiplatelet effect and increased risk of thrombotic events Details Diltiazem Cobimetinib Cotellic Increased cobimetinib plasma concentrations Details Diltiazem Cyclosporine Injection Atopica Increased cycloSPORINE exposure, an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) and an... Details Diltiazem Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure, an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) and an... Details Diltiazem Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Diltiazem Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Diltiazem Deflazacort Emflaza Increased exposure to active metabolite of deflazacort Details Diltiazem Dexamethasone Injection Decadron Reduced dilTIAZem exposure Details Diltiazem Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced dilTIAZem exposure Details Diltiazem Digoxin Cardoxin® Increased digoxin exposure and an increased risk of bradycardia and advanced complete heart block Details Diltiazem Dihydroergotamine Injection DHE-45® Injection Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Diltiazem Dihydroergotamine Nasal Spray Migranal Increased dihydroergotamine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Diltiazem Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Diltiazem Elacestrant Orserdu Increased elacestrant exposure and an increased risk of elacestrant-related adverse effects Details Diltiazem Encorafenib Braftovi Increased encorafenib exposure and an increased risk of encorafenib-related adverse events Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.