Lesinurad

Major

Lesinurad Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Lesinurad Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Lesinurad Atogepant Qulipta Reduced atogepant exposure Details Lesinurad Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Lesinurad Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Lesinurad Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Lesinurad Amlodipine Amvaz® Reduced amLODIPine exposure Details Lesinurad Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Lesinurad Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Lesinurad Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Lesinurad Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Lesinurad Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Lesinurad Doravirine Pifeltro Reduced doravirine exposure and reduced efficacy of doravirine Details Lesinurad Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased risk of breakthrough bleeding an... Details Lesinurad Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased risk of breakthrough bleeding an... Details Lesinurad Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased risk of breakthrough bleeding an... Details Lesinurad Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Lesinurad Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Lesinurad Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Lesinurad Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Lesinurad Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Lesinurad Lenacapavir Injection Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Lesinurad Lenacapavir Oral Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Lesinurad Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Lesinurad Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Lesinurad Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Lesinurad Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Lesinurad Lumateperone Caplyta Reduced lumateperone exposure Details Lesinurad Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased risk of breakthrough bleeding an... Details Lesinurad Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and increased risk of breakthrough bleeding an... Details Lesinurad Mitapivat Aqvesme Reduced mitapivat exposure and reduced efficacy of mitapivat Details Lesinurad Nifedipine Adalat® Reduced NIFEdipine exposure Details

Moderate

Lesinurad Aspirin Acuprin® Decreased efficacy of lesinurad Details Lesinurad Aspirin Rectal Aspirin Decreased efficacy of lesinurad Details Lesinurad Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Lesinurad Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details