Diindolylmethane - Entyvio (Vedolizumab) Interaction

Interaction Details

Pharmacist Analysis

DIM does have some theoretical drug interactions to be aware of, but they are generally believed to be only mild to moderate in nature.

Potential drug interactions with DIM include drugs in the following classes:

• Drugs that are metabolized by the liver enzyme CYP1A2: DIM may induce this enzyme, increasing the metabolism of certain drugs.
• Diuretics: DIM may reduce sodium levels, and could have additive effects with diuretics that increase sodium loss.
• Estrogen: DIM may have both estrogenic and anti-estrogen effects.

These are all detailed in individual interaction pages.

There is no known interaction between DIM and the drug in question, however.

Nevertheless, always be sure to tell your doctor about all the medications you are taking, supplements included.

Vedolizumab Overview

• Vedolizumab injection is used to relieve the symptoms of certain autoimmune disorders (conditions in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage) of the gastrointestinal tract including:

  • Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) that has not improved when treated with other medications.

  • ulcerative colitis (condition that causes swelling and sores in the lining of the large intestine) that has not improved when treated with other medications.

• Vedolizumab injection is in a class of medications called integrin receptor antagonists. It works by blocking the action of certain cells in the body that cause inflammation.

Diindolylmethane - More Interactions

Diindolylmethane interacts with 268 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.